This book is essentially a commentary on John Locke’s masterwork, his An Essay Concerning Human Understanding, which is the foundational work of classical Empiricism. It aims to be accessible to students who are reading Locke for the first time, to be a useful research tool for upper-level undergraduate and graduate students, and to make a contribution to Locke scholarship. It is designed to be read alongside the Essay, but does not presuppose familiarity with it. It expounds and critically discusses the main theses and arguments of each of the Essay’s four books, on the innatism that Locke opposes, the origin and classification of ideas, language and meaning, and knowledge, respectively. It analyzes Locke’s influential explorations of related topics, including primary and secondary qualities, substance, identity, personal identity, free will, nominal and real essence, and external-world skepticism, among others. It is written in an analytical style that strives for clarity and that offers step-by-step reconstructions of Locke’s arguments. It references and engages with relevant work of other major philosophers and Locke commentators, including, among others, Descartes, Leibniz, Berkeley, Hume, Kant, Thomas Reid, John Yolton, James Gibson, R. M. Chisholm, Michael Ayers, John Perry, John Mackie, Roger Woolhouse, Saul Kripke, Jonathan Bennett, E. J. Lowe, Vere Chappell, Samuel Rickless, Galen Strawson, Gideon Yaffe, and Matthew Stuart.