Petroleum and natural gas exploration and development are deepening, and the environment and stratum conditions encountered are becoming more and more complex. There are many high-temperature, high-pressure, high-corrosion wells, and the number of ultra-short horizontal directional wells, ultra-deep wells, and extended reach wells are also increasing. The steel drill pipe has not been able to meet and adapt to these requirements. Titanium alloy drill pipe has a series of advantages such as low density, high specific strength, excellent corrosion resistance, high temperature resistance, fatigue resistance, non-magnetic and good flexibility. It is suitable for the development of modern petroleum industry. This article discusses the use of titanium alloy drill pipe in domestic and foreign drilling in horizontal wells with short radius, the design of alloy components in titanium alloy drill pipes, body pipe processing, joint connection and corrosion resistance. Combining the practical application of titanium alloy drill pipe points out the current problems. Finally, from the aspect of drilling cycle, production safety and cost saving, the development and application of titanium alloy drill pipes in deep wells, ultra-deep wells and deep-sea drilling operations are prospected.