Remote sensing and thematic data were used to provide comprehensive views of surface conditions related to land degradation and desertification, considered environmental extremes in arid and semi-arid regions. The current work applies techniques, starting with simple visual analyses up to a parametric methodology, adopted from the FAO/UNEP and UNESCO provisional methodology for assessment and mapping of soil degradation. Egyptian case studies are highlighted to insinuate on studied aspects. Variable satellite imageries (MSS, TM, and ETM) and aerial photographs were utilized to provide data on soil conditions, land cover, and land use. IDRISI and ArcGIS software were used to manage thematic data, while ERDAS IMAGIN was used to process satellite data and to derive the normalized difference vegetation index (NDVI) values. A GIS model was established to modify the universal soil loss equation (USLE) calculating the present state and risk of soil degradation. The study area is found exposed to slight hazard of water erosion, however, and to high risk of wind erosion. It is also threatened by a slight to high salinization and slight to moderate physical degradation. It is recommended to use a GIS in detailed and very detailed studies for evaluating soil potentiality in agricultural expansion areas.