A New TOPSIS Methodology Based on Single-Valued Neutrosophic Numbers for Selection of Suitable Roll Stabilizer Type for Motor Yachts

Selection of a suitable stabilization system for motor yachts is a challenging problem for both owners and designers. Also, this is a good sample of multicriteria decision-making problem that includes many criteria required to be assessed at the same time. The present work aims to propose an extended Technique for Order Preference by Similarity to Ideal Solution methodology based on single-valued neutrosophic numbers which represent the uncertainty of real-world applications. A questionnaire was applied to a group of experts who were asked to evaluate four different stabilizer alternatives according to the 15 criteria determined. Evaluations of the experts were analyzed through the proposed methodology, and results were presented and discussed.

CFD SIMULATION OF TEMPERATURE REGIMES OF THE COMBUSTION ZONE OF STABILIZER-TYPE BURNERS WITH ASYMMETRIC FUEL SUPPLY

The results of computer simulation of the heat state of the combustion zone and the burnup rate of fuel for stabilizer burners with asymmetric fuel distribution are presented. The features of temperature fields in this zone that are characteristic of the conditions under study are revealed. The analysis of these features in the aspect of their conditionality by the two-stage combustion of fuel gas is carried out.

Long-Acting Paliperidone Parenteral Formulations Based on Polycaprolactone Nanoparticles; the Influence of Stabilizer and Chitosan on In Vitro Release, Protein Adsorption, and Cytotoxicity

Long-acting preparations containing the antipsychotic paliperidone for intramuscular injection has drawn considerable attention to achieve harmless long-term treatment. This study aimed to develop paliperidone loaded polycaprolactone (PCL) nanoparticles and investigate the influence of PCL/drug ratio, stabilizer type, and chitosan coating on physicochemical properties, protein adsorption, and cellular toxicity. Results showed that chitosan coating produced enlarged particle sizes, shifted the surface charges from negative into positive and did not influence encapsulation efficiencies. Chitosan coating relatively sustained the drug release especially in pluronic stabilized formulations. Pluronic F127 based formulations exhibited the least protein adsorption (384.3 μg/mL). Chitosan coating of Tween 80 and polyvinyl alcohol stabilized formulations significantly (p < 0.05) increased protein adsorption. Cellular viability was concentration-dependent and negatively affected by stabilizers. All formulations did not show cellular death at 1.56 μg/mL. Inflammatory responses and oxidative stress were less affected by Tween 80 compared with other stabilizers. Chitosan minimized all aspects of cellular toxicity. Collectively, stabilizer type and chitosan coating play critical roles in developing safe and effective long-acting PCL nanoparticles intended for parenteral drug delivery. The coated formulations containing Tween 80 and Pluronic F127 as stabilizers are warranted a future in vivo study to delineate its safety and efficacy profiles.

CFD SIMULATION OF TEMPERATURE REGIMES OF THE COMBUSTION ZONE OF STABILIZER-TYPE BURNERS WITH ASYMMETRIC FUEL SUPPLY

The results of computer simulation of the heat state of the combustion zone and the burnup rate of fuel for stabilizer burners with asymmetric fuel distribution are presented. The features of temperature fields in this zone that are characteristic of the conditions under study are revealed. The analysis of these features in the aspect of their conditionality by the two-stage combustion of fuel gas is carried out.

FEATURES OF FLOW AND HEAT TRANSFER IN THE INNER CAVITY OF THE FLAME STABILIZER IN THE PRESENCE AND ABSENCE OF NICHES ON ITS SIDE SURFACES

For microjet burners of the stabilizer type, a study of the regularities of the natural gas flow in the inner cavity of the flame stabilizer has been carried out. A comparative analysis of the features of heat transfer from the inner surfaces of the stabilizer walls is carried out for two variants of its configuration: flat and in the presence of trapezoidal niches on its lateral surfaces.