Creativity is viewed as the ultimate outcome of multiple evolutions nested within the human brain at the level of its genes, its cells, its neuronal networks, its cognitive architecture, and through its epigenetic sociocultural interactions. The creative experience is an endogenous process that makes incoming and/or internally generated information globally available to multiple brain systems through a distributed network, which Changeux and colleagues have long established as the global neuronal workspace (GNW) of neurons with long-range axons, particularly dense in prefrontal, parietotemporal, and cingulate cortex. Creation proceeds from the internal production of transitory patterns of neurons or pre-representations. Within the Darwinian framework, the brain’s spontaneous activity is a source of “epigenetic” diversity which preexists in the brain in its interaction with the outside world. It contributes to a synthesis within the neuronal workspace of external perceptions, internal memories, and stored emotions. The combinatorial access of the GNW to a broad diversity of representations is a unique kind of ignition process, one that can be called esthetic ignition. The creative act itself involves the selection of pre-representations according to a set of stored, innate rules of art such as novelty, parsimony, and harmony. This artistic process describes the creation and contemplation of visual art according to a neuroaesthetic analysis which reveals the neural origins of aesthetic pleasure and artistic creation.