CLINICAL APPLICATION OF GENE MEDICINE IN PREVENTING SPORTS INJURIES

ABSTRACT Introduction: Using gene therapy to transfer specific genes to implant therapeutic proteins into damaged tissues is a more promising way to treat sports injuries. The combination of tissue engineering and gene therapy will potentially promote the regeneration and repair of various damaged tissues. Objective: This article explores the adaptive relationship between gene selection therapy and athletes in sports. Methods: We selected students of related majors in sports schools to conduct specific genetic testing and measure the muscle area, fatigue level, muscle damage, and other related indicators before and after exercise. Results: After a series of physical fitness assessments, an increase in the gene sequence, as well as changes in the biochemical indices, were confirmed Conclusions: The muscle gain of the test subject during training is better than other genotypes. Level of evidence II; Therapeutic studies - investigation of treatment results.

Ecological Adaptation of Endemic Anthocleista Species under Moisture Gradient in Parts of Niger Delta, Nigeria

Background: Knowledge of the anatomy of Anthocleista species is crucial for understanding how these plants adapt to the environment. Aim: This study was aimed at investigating the adaptive relationship of moisture gradient influence on the anatomy of four species in the genus Anthocleista (A djalonesis A Chev; A. liebrechtsiana De Wild & Th.Dur; A. nobilis G.Don; and A. vogelii Planch) in light of ecological niche adaptation. Place of Study: parts of Akwa-Ibom, Bayelsa, Cross River and Rivers States in the Niger Delta. Methods: Conventional classical anatomical techniques for structural sectioning were used. Results: Though there are similarities and differences in vascular structure among the species, the study has revealed variance in anatomical responses to moisture gradient (ranging from dry mesophytic to mesophytic and wetland conditions) of adaptation. The most important and distinct features observed are the presence of sclerenchymatous idioblast, air sacs and sclereidal idioblast. Sclerenchymatous idioblasts are numerous in A liebrechtsiana, few in A. nobilis and A. vogelii but lacking in A. djalonesis. The sclerenchymatous idioblast in A. liebrechtsiana, A. nobilis, and A. vogelii confirmed these species to be mesophytic to semi-aquatic in their habitat adaptation; while A. djalonesis is dry-mesophytic in adaptation with thicker epidermal layer, multiple hypodermal layers, thicker mesophyll tissues with increased number of palisade layers and thick leaves. The stem and root modification had abundance sclereidal idioblast distribution in A. liebrechtsiana, and A. nobilis, moderate in A. vogelii and very low in A. djalonesis. Conclusion: The variation observed in the leaf, petiole, stem and root anatomical characters are due to moisture gradient influence with the resultant effect of plant species evolving structures such as idioblast and modification to adapt to the niche and environment where they find themselves.

Correctional Rehabilitation and Human Functioning: An Embodied, Embedded, and Enactive Approach

<p>In order for correctional rehabilitation practices to be maximally effective, they should be grounded in well-developed psychological theory about the causes, development, and nature of crime. This thesis argues that these theories of crime should be based in an underlying perspective of human functioning, or how people work at a fundamental level. I argue that this level of theory has been neglected in theories of crime, as demonstrated through an evaluation of the Risk-Need-Responsivity model of rehabilitation, which currently stands as the most popular and widely used rehabilitation framework throughout much of the world. This perspective is understood to implicitly present a view of functioning which is reward-oriented, multifactorial, norm-based, and modular, resulting in limited explanatory value and diminished treatment efficacy. I then suggest an alternative model of functioning as being embodied, embedded, and enactive (3e). 3e places an emphasis on the individual as an embodied whole, in an adaptive relationship with their physical and social environment. 3e prioritises the affective experience and agency of the individual, with a commitment to viewing the person as a functional whole drawing on comprehensive multilevel explanations. I outline how this perspective could be used to inform the explanation of crime, before applying the model to an exemplar to demonstrate the potential treatment utility of a 3e approach to correctional rehabilitation, as opposed to an RNR approach.</p>

Correctional Rehabilitation and Human Functioning: An Embodied, Embedded, and Enactive Approach

<p>In order for correctional rehabilitation practices to be maximally effective, they should be grounded in well-developed psychological theory about the causes, development, and nature of crime. This thesis argues that these theories of crime should be based in an underlying perspective of human functioning, or how people work at a fundamental level. I argue that this level of theory has been neglected in theories of crime, as demonstrated through an evaluation of the Risk-Need-Responsivity model of rehabilitation, which currently stands as the most popular and widely used rehabilitation framework throughout much of the world. This perspective is understood to implicitly present a view of functioning which is reward-oriented, multifactorial, norm-based, and modular, resulting in limited explanatory value and diminished treatment efficacy. I then suggest an alternative model of functioning as being embodied, embedded, and enactive (3e). 3e places an emphasis on the individual as an embodied whole, in an adaptive relationship with their physical and social environment. 3e prioritises the affective experience and agency of the individual, with a commitment to viewing the person as a functional whole drawing on comprehensive multilevel explanations. I outline how this perspective could be used to inform the explanation of crime, before applying the model to an exemplar to demonstrate the potential treatment utility of a 3e approach to correctional rehabilitation, as opposed to an RNR approach.</p>

What Is a Videogame Movie?

Cinematic adaptations of videogames are an increasingly common feature of film culture, and the adaptive relationship between these mediums is an increasingly common subject of film and videogame studies. However, our ability to historicize and theorize that relationship is hampered by a failure to fully define the generic character of our object of study. This essay asks, what is a videogame movie? It argues that film scholars (1) have not considered the full range of ways videogames have been represented in film; (2) have not attended fully to the historical, technological, figurative, and social dimensions of videogames; and therefore (3) have limited the set of possible texts that comprise the genre “videogame cinema.” The essay recommends a tropological approach to the problem, defining six tropes that comprise the “videogame movie” as a genre, and applying them to two films, Her and 1917, neither of them a direct adaptation of a videogame, the latter not “about” or referencing videogames in any way, yet both exemplary of a broadened concept of “videogame cinema”.

CICLOS COGNITIVOS INTERPESSOAIS: DESAFIOS E ESTRATÉGIAS DE FORTALECIMENTO DA RELAÇÃO TERAPÊUTICA

COGNITIVE INTERPERSONAL CYCLES: CHALLENGES AND STRATEGIES TO THE STRENGTHEN THE THERAPEUTIC RELATIONAssuming Jeremy Safran theoretical proposal as the frame conceptual approach, the present article is devoted to the problematic of cognitive interpersonal cycles and, in its scope, to their relevance in the context of relationally focused intervention. We proceed to a comprehensive synthesis of the construct in analysis, emphasizing its major referents and highlighting the key attributes that characterize it. These elements exposed, we progress to the examination of the specificities that the process of developing and strengthening of the therapeutic relationship should assume in this context, in specific, underlining, in this matter, its fundamental role as an instrument of the therapeutic process itself. We briefly explore how this relationship can constitute, in itself, as an important mechanism for the disconfirmation of maladaptive schemes and unbundling of crystallized interpersonal cognitive cycles. We present, in addition to the above, some strategies and techniques of strengthening of this therapeutic alliance, of which excels the meta-communication, given its gains in the establishment of an adaptive relationship between patient and therapist. We conclude by presenting a critical analysis of current studies, referencing future research needs.Key-words: Interpersonal cognitive cycles; therapeutic relationship; relationally focused interventionResumo.Assumindo como abordagem conceptual de base a proposta teórica de Jeremy Safran, o presente artigo é devotado à problemática dos ciclos cognitivos interpessoais e, no seu âmbito, à relevância que estes possuem no contexto da terapia focada nas relações. Procede-se, por conseguinte, a uma síntese compreensiva do construto em análise, apontando os seus referentes principais e salientando os atributos chave que o caracterizam. Expostos estes elementos procede-se ao exame das especificidades que o processo de formação e fortalecimento da relação terapêutica deve assumir neste âmbito em específico, salientando-se, para o efeito, o seu papel fundamental enquanto instrumento do próprio processo terapêutico. Explora-se, de forma breve, como esta relação se pode constituir como um importante mecanismo de desconfirmação de esquemas mal-adaptativos e, também, de desagregação de ciclos cognitivos interpessoais cristalizados. Apresentam-se, em complemento ao exposto, algumas estratégias e técnicas de potenciação desta aliança terapêutica, das quais se notabiliza a meta-comunicação, dadas as suas mais-valias no estabelecimento de relação adaptativa entre paciente e terapeuta. Conclui-se apresentando uma análise crítica dos estudos atuais, referenciando necessidades de investigação futuras. Palavras-chave: Ciclos cognitivos interpessoais, relação terapêutica, intervenção focada nas relações