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Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 132
Author(s):  
Zhenqiang Yao ◽  
Stephen J. Getting ◽  
Ian C. Locke

Increased osteoclast (OC) differentiation and activity is the critical event that results in bone loss and joint destruction in common pathological bone conditions, such as osteoporosis and rheumatoid arthritis (RA). RANKL and its decoy receptor, osteoprotegerin (OPG), control OC differentiation and activity. However, there is a specific concern of a rebound effect of denosumab discontinuation in treating osteoporosis. TNFα can induce OC differentiation that is independent of the RANKL/RANK system. In this review, we discuss the factors that negatively and positively regulate TNFα induction of OC formation, and the mechanisms involved to inform the design of new anti-resorptive agents for the treatment of bone conditions with enhanced OC formation. Similar to, and being independent of, RANKL, TNFα recruits TNF receptor-associated factors (TRAFs) to sequentially activate transcriptional factors NF-κB p50 and p52, followed by c-Fos, and then NFATc1 to induce OC differentiation. However, induction of OC formation by TNFα alone is very limited, since it also induces many inhibitory proteins, such as TRAF3, p100, IRF8, and RBP-j. TNFα induction of OC differentiation is, however, versatile, and Interleukin-1 or TGFβ1 can enhance TNFα-induced OC formation through a mechanism which is independent of RANKL, TRAF6, and/or NF-κB. However, TNFα polarized macrophages also produce anabolic factors, including insulin such as 6 peptide and Jagged1, to slow down bone loss in the pathological conditions. Thus, the development of novel approaches targeting TNFα signaling should focus on its downstream molecules that do not affect its anabolic effect.


Author(s):  
Nathan Emmerich ◽  
Pat McConville

The COVID-19 pandemic has occasioned a great deal of ethical reflection both in general and on the issue of reverse triage; a practice that effectively reallocates resources from one patient to another on the basis of the latter having a more favourable clinical prognosis. This paper addresses a specific concern that has arisen in relation to such proposals: the potential reallocation of ventilators relied upon by disabled or chronically ill patients. This issue is examined via three morally parallel scenarios. First, the standard reallocation of a ventilator in accordance with reverse triage protocols; second, the reallocation of a personal ventilator from a chronically ill patient ordinarily reliant on it; and, third, the reallocation of a personal ventilator owned by a financially privileged individual but who is not ordinarily reliant on it. This paper suggests that whilst property rights cannot resolve these scenarios in a satisfactory manner, it may be possible to do so if we draw on the resources of phenomenology. However, in contradistinction to a recent paper on this topic (Reynolds et al. 2021), we argue that ethical claims to ventilators are not well grounded by the overly demanding notion that they are embodied objects. We suggest that the alternative phenomenological notion of homelikeness provides for a more plausible resolution of the issue. The personal ventilators of individuals who commonly rely upon them become part of their ordinary, everyday or homelike being. They are a necessary part of the continuation or maintenance of their basic state of health or wellbeing and the reallocation of such objects is unethical. Keywords: Phenomenology, COVID-19, Pandemic, Triage, Reverse triage, Ventilation, Chronic illness, Allocation of resources


2021 ◽  
Author(s):  
◽  
Tony Rex Smith

<p>We criticise the current philosophical practice of invoking causation as a solution to various problems in various fields of philosophy. Our specific concern is that many of these solutions to problems rely on the intuition that causation is "the cement of the universe". We question whether several different analyses of causation which are supposed to substantiate this intuition (or at least are treated as if they substantiate this intuition) in fact substantiate this intuition. We begin by establishing a basic desideratum for such an analysis of causation - that causal dependence ought to track physical dependence in this universe. We investigate in turn a Lewis-style counterfactual analysis of causation, the transference analysis developed by Aronson, Fair and Heathcote, and the process analyses developed by Salmon and Dowe. Rather to our surprise, none of the analyses fulfil our basic desideratum. Although this is not in itself conclusive grounds for scepticism about causation, our results speak against casually invoking analyses of causation in order to solve particular varieties of philosophical problems.</p>


2021 ◽  
Author(s):  
◽  
Tony Rex Smith

<p>We criticise the current philosophical practice of invoking causation as a solution to various problems in various fields of philosophy. Our specific concern is that many of these solutions to problems rely on the intuition that causation is "the cement of the universe". We question whether several different analyses of causation which are supposed to substantiate this intuition (or at least are treated as if they substantiate this intuition) in fact substantiate this intuition. We begin by establishing a basic desideratum for such an analysis of causation - that causal dependence ought to track physical dependence in this universe. We investigate in turn a Lewis-style counterfactual analysis of causation, the transference analysis developed by Aronson, Fair and Heathcote, and the process analyses developed by Salmon and Dowe. Rather to our surprise, none of the analyses fulfil our basic desideratum. Although this is not in itself conclusive grounds for scepticism about causation, our results speak against casually invoking analyses of causation in order to solve particular varieties of philosophical problems.</p>


Author(s):  
Thomas Bierschenk ◽  
Jean-Pierre Olivier de Sardan

Anthropology is a latecomer to the study of bureaucracy. Nonetheless, the anthropological study of organizations—of which bureaucracies are a subtype, as larger organizations are always bureaucratically organized—was initiated by anthropologists as early as the 1920s. Since the 2010s, the anthropology of bureaucracy has slowly consolidated into a discernible subfield of the discipline. It brings to the study of public administrations a double added value: (a) a specific concern for the informal aspects of bureaucracy, (b) the emic views of bureaucratic actors and their pragmatic contexts, based on long-term immersion in the research field, as well as (c) a non-Eurocentric, global comparative perspective. Anthropologists have focused on bureaucratic actors (“bureaucrats”), the discursive, relational, and material contexts in which they work, the public policies they are supposed to implement or to comply with, and their interactions with the outside world, in particular ordinary citizens (“clients”). A foundational theorem of the anthropological study of bureaucracies has been that you cannot understand organizations on the basis of their official structures alone: the actual workings of an organization are largely based on informal practices and practical rules; there is always a gap between organizational norms and “real” practices; large-scale organizations are heterogeneous phenomena; and conflicts, negotiations, alliances, and power relations are their core components. Thus, one of the major methodological achievements of the anthropology of bureaucracy has been to focus on the dialectics of formal organization and real practices, official regulations, and informal norms in organizations “at work.”


2021 ◽  
Author(s):  
Christopher Joseph Cachia

While Hip Hop culture has regularly been legitimized within academia as a social phenomenon worthy of scholarly attention (witness the growing number of studies and disciplines now taking Hip Hop as object for analysis), this is the first Hip Hop-themed project being completed within the academy. Indeed, academic and critical considerations of one's own Hip Hop-based musical production is a novel venture; this project, as a fusion of theory with practice, has thus been undertaken so as to occupy that gap. The paper's specific concern is with how (independent) Hip Hop recording artists work to construct their own selves and identity (as formed primarily through lyrical content); the aim here is to explore Hip Hop music and the construction of artistic self· presentation. I therefore went about the task of creating my own album - my own Hip Hop themed musical product - in order to place myself in the unique position to examine it critically as cultural artifact, as well as to write commentary and (self-)analyses concerning various aspects of (my) identity formation. The ensuing outlined tripartite theoretical framework is to serve as a model through which other rappers/academics may think about, discuss, and analyze their own musical output, their own identities, their own selves.


2021 ◽  
Author(s):  
Christopher Joseph Cachia

While Hip Hop culture has regularly been legitimized within academia as a social phenomenon worthy of scholarly attention (witness the growing number of studies and disciplines now taking Hip Hop as object for analysis), this is the first Hip Hop-themed project being completed within the academy. Indeed, academic and critical considerations of one's own Hip Hop-based musical production is a novel venture; this project, as a fusion of theory with practice, has thus been undertaken so as to occupy that gap. The paper's specific concern is with how (independent) Hip Hop recording artists work to construct their own selves and identity (as formed primarily through lyrical content); the aim here is to explore Hip Hop music and the construction of artistic self· presentation. I therefore went about the task of creating my own album - my own Hip Hop themed musical product - in order to place myself in the unique position to examine it critically as cultural artifact, as well as to write commentary and (self-)analyses concerning various aspects of (my) identity formation. The ensuing outlined tripartite theoretical framework is to serve as a model through which other rappers/academics may think about, discuss, and analyze their own musical output, their own identities, their own selves.


2021 ◽  
Vol 12 (1) ◽  
pp. 3
Author(s):  
Sarah Haider ◽  
Dheyaa J Kadhim ◽  
Sarmad A. Abdul Razzak

Objectives: This study aimed to evaluate beliefs about use of medications for a sample of Iraqi psoriasis patients, and to examine the association between these beliefs and selected patient’s related factors. Methods: This cross-sectional study included 300 patients with diagnosed psoriasis. Participants were recruited at the center of Dermatology and Venereology, Medical City in Baghdad, the capital city of Iraq. Patients’ mean age was 35.15years (±10.54). Beliefs about medicines were measured by the Arabic version of Beliefs about Medicines Questionnaire. Results: Most the patients (76.7%) had strong beliefs in the need (acceptance beliefs) for their psoriasis medicines (specific-necessity score higher than specific-concern), whereas 15.0% of patients had specific-concern score higher than specific-necessity and 8.3% of patients had specific-necessity score equal to specific-concern. At the same time, 74.4% of the patients believed that the medicines disrupt their lives and (35.6%) of them had concerns about the possibility of becoming addicted on these medicines. Many other patients were worried about the long-term consequences of the medicines (58.7%). In addition, 31.0% of the participants believe that all medicines are poisoning, and that they do more harm than good. Finally, many of the participants believed that physicians prescribe too many medicines (46.7%), and they can minimize the number of prescribed medicines by spending more time with their patients (32.6%). Conclusions: Female gender and longer disease duration have direct association with specific necessity, while psoriasis severity has a direct association with specific concern. In conclusion, Beliefs about medications and habit strength are important modifiable drivers to enhance adherence and clinical outcomes in the control of psoriasis.


2020 ◽  
Vol 22 (9) ◽  
pp. 1680-1698 ◽  
Author(s):  
Rebecca Coleman

Digital media time is commonly described as ‘real-time’. But what does this term refer to? How is ‘real-time’ made, managed and experienced? This article explores these questions, drawing on interviews with UK-based digital media professionals. Its specific concern is with how accounts of the time of digital media indicate a particular, yet supple, temporality, which emphasises ‘the now’. I draw on current literature that explores how real-time is a temporality capable of being stretched and condensed, or variously compressed and paced. While much of this literature focuses on the technological fabrication of real-time, I explore how ‘the now’ is produced through the interplay between human and non-human practices. Through discussion of the interviews, the article concentrates on social, cultural and affective dimensions of ‘the now’, fleshing out more technologically focused work and contributing to understanding of a prevalent way in which time is organised in contemporary digital societies.


2020 ◽  
Vol 9 (8) ◽  
pp. 804-811
Author(s):  
Salem A Beshyah ◽  
Khawla F Ali ◽  
Hussein F Saadi

Introduction: Appropriate dose adjustments of glucocorticoids replacement therapy for adrenal insufficiency (AI) is vital. Objective: We sought to scope physicians’ perceptions, and practices regarding Ramadan fasting (RF) impact on the management of AI. Methods: A web-based survey of a convenience sample of endocrinologists. Results: Nearly two-thirds of 145 respondents (64.1%) were adult endocrinologists and almost half (49%) saw more than 10 hypoadrenal patients per year. Most respondents (78.6%) prescribed hydrocortisone, while the minority prescribed other preparations. The glucocorticoid doses were reportedly divided twice daily by 70.8% and thrice daily by 22.2% of respondents. Respondents recognized RF as having potential consequences in adrenal insufficiency patients included causing hypoglycaemia, undue tiredness, and fatigue, hypotension, feeling dizzy, and light-headedness. Symptoms of under-replacement were thought to happen in the late afternoon by 59.3% of respondents. Almost half (45.5%) of respondents thought that RF has some probable or definite impact on glucocorticoid therapy that certainly warrants specific concern and possible action. Three quarters (76.4%) of respondents confirmed providing specific management recommendations during RF. The most frequently reported recommendation was taking in the usual morning dose of hydrocortisone just before pre-dawn meal (Suhor) (57.8%). A third switch patients from hydrocortisone to prednisolone/prednisone. Half reported providing patients with specific recommendations regarding breaking their fast and/or seeking help if hypoadrenal symptoms occur. Conclusions: There is a remarkable variation in the physicians’ perceptions and practices regarding the management of AI during Ramadan. This warrants professional effort to increase the awareness and dissemination of evidence-based guidelines.


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