The smart grid (SG) is a movement to bring the electrical power grid up to date so it can meet current and future requirements to fit customer needs. Disturbances in SG operation can originate from natural disasters, failures, human factors, terrorism, and so on. Outages and faults will cause serious problems and failures in the interconnected power systems, propagating into critical infrastructures such as nuclear industries, telecommunication systems, etc. Nuclear power plants (NPP) are an intrinsic part of the future smart grid. Therefore, it is of high priority to consider SG safety, mutual influence between NPP and SG, forecast possible accidents and failures of this interaction, and consider the strategies to avoid them.