This new chapter highlights the importance of recognizing, assessing, and managing patients in pain safely in the acute care setting, and particularly when they are acutely ill. It explains pain theories, the importance of assessment and management of pain and explores the use of pharmacological, non-pharmacological and invasive analgesic techniques during acute care: which include the use of patient controlled analgesia (PCA); and regional analgesia including spinals, epidurals and continuous perineural blockade (CPNB). The use of intravenous lidocaine and plasters are also discussed.