Antiparasitary Activity Of The Juglone Compound: A Narrative Review

Objective: To report, based on the literature, the action of the compound 5-hydroxy-1,4-naphthoquinone against parasites (protozoa and helminths) that affect humans. Methods: This is a narrative review that used Pubmed and Google Scholar as a data tool. This work included articles published until September 2020 that were directly related to the use of the compound juglone in antiparasitic trials. Results: The compound juglone demonstrated promising effects as a human and animal antiparasitic substance. In protozoa, the Apicomplexo Toxoplasma gondii parasite showed a high mortality rate in concentrations of juglone in the nanomolar range. The juglone showed an average inhibitory concentration (IC50) of 1.62 µM, >100 µM, and 2.02 µM µM for Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani, respectively. Also, the juglone showed antihelmintic activity on Hymenolepis nana in mice, and on adult worms of Schistosoma mansoni (LE strain) with IC50 34.16 µM, 32.14 µM, and 25 µM in the 24h, 48h, and 72 h, respectively. Conclusion: The results published so far show the in vitro antiparasitic potential of juglone, and the need for further studies on the specific mode of action that interacts with parasites. Besides, the literature is still limited to studies that evaluate in vivo the compound juglone, requiring better information on its interaction with living organisms.

Alpha-emitting nanoparticles and the Warburg Effect, skin diseases, eating disorders, musculoskeletal disorders, alcoholism, cigarette, hypersexuality and neurofibromatosis type 1

Alpha emitting nanoparticulates in internal contamination, an IARC Class 1 carcinogen, have an extremely wide list of effects. New effects are here demonstrated based on a wide epidemiological survey. WHO data in particular is used together with other large sets and juxtaposed to known sources of variations of radioactivity contamination in the environment to demonstrate the link which is always explained by the strong decay energy and its impact on the organism. Some behaviours are shown to be strategies of pain reduction, others of decontamination. This article confirms the simple logic of biophysics (the linear-no-threshold model) outlined by the author in previous publications.

“Organic food” – makes pharmaceutical industries work against insects – a danger for society in general

The author’s works have shown in various ways the absence of dangerosity of pesticides for human health, as all the studies claiming to find effects forget the side contamination with alpha-emitting nanoparticulates (from radon, phosphated fertilizers, car fumes, coal ashes for instance) that interacts with the samples and destroys the scientific validity of the results. This paper looks at the issue of organic food in a different way, because organic food also thrives on the sheer claim that it benefits to insects, and the author’s results here show that this is not the case too.

A TRIGA-like subcritical concept for biological waste management (pills, old vaccines etc.)

This subcritical concept is framed in a way that allows use in a single room for some electricity production purposes. It involves a tungsten casing and also helps using depleted uranium dust. The single series of anneals for closure and direct laying of the top opening window onto the left side of the tungsten casing make pressure work impossible ; it also allows for a relatively cheap production.