The COVID-19 pandemic has negatively impacted the global community in ways unimaginable. The Ghanaian COVID-19 response has been touted as effective to a large extent from the viewpoint that the government provided leadership based on scientific data with collaboration from traditional leaders, faith based, civil societies etc. This article discusses inadvertent “omissions and commissions'' on the part of the government and the people of Ghana defined as “missed preventive health and behavioural opportunities'' that would possibly have reduced the current morbidities and mortalities. Important lessons are drawn and recommendations made for future national responses to epi-and pandemics. Using secondary data, extant relevant publications (peer – reviewed articles, online blogs etc.) on the subject were retrieved, critically appraised to complement the authors’ ideas in this special article. The study found among others, some missed preventive opportunities included delayed mandatory quarantine, border closures, too flexible partial lockdown, facemasks wearing as an afterthought of COVID-19 protocol, and non-enforcement of executive instruments on the part of government. Moreover, a significant proportion of the citizenry has remained non-compliant with the President’s instituted protocols to date. The study recommends that Governments should strengthen their nations’ disease surveillance systems, be willing to initiate stringent, unpopular but effective and uncompromising public protection protocols to mitigate such outbreaks. These may include closing borders and entry ports promptly (or a more regulated one), imposing lockdowns, instituting aggressive public education in collaboration with relevant bodies. On the part of the citizenry, executive instruments must be enforced to the latter with commensurate understandable education. Finally, traditional leaders, faith based and civil societies, should embark on mass education, national drives for necessary PPE’s and food for the poor and vulnerable as they collaborate with the authorities on other relevant fronts.