Single community research networks. The HARNET experience. Harrisburg Area Research Network

1993 ◽  
Vol 2 (7) ◽  
pp. 725-728
Author(s):  
D. C. Slawson
Keyword(s):  
Research Network ◽  
Community Research ◽  
Research Networks

scholarly journals Genetic epidemiology of BRCA1- and BRCA2-associated cancer across Latin America

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Josef S. Herzog ◽  
Yanin Chavarri-Guerra ◽  
Danielle Castillo ◽  
Julio Abugattas ◽  
Cynthia Villarreal-Garza ◽  
...  
Keyword(s):  
Latin America ◽  
Latin American ◽  
Cancer Genomics ◽  
Low Cost ◽  
Probability Model ◽  
Copy Number Variant ◽  
Research Network ◽  
Community Research ◽  
Brca1 And Brca2 ◽  
Pathogenic Variants

AbstractThe prevalence and contribution of BRCA1/2 (BRCA) pathogenic variants (PVs) to the cancer burden in Latin America are not well understood. This study aims to address this disparity. BRCA analyses were performed on prospectively enrolled Latin American Clinical Cancer Genomics Community Research Network participants via a combination of methods: a Hispanic Mutation Panel (HISPANEL) on MassARRAY; semiconductor sequencing; and copy number variant (CNV) detection. BRCA PV probability was calculated using BRCAPRO. Among 1,627 participants (95.2% with cancer), we detected 236 (14.5%) BRCA PVs; 160 BRCA1 (31% CNVs); 76 BRCA2 PV frequency varied by country: 26% Brazil, 9% Colombia, 13% Peru, and 17% Mexico. Recurrent PVs (seen ≥3 times), some region-specific, represented 42.8% (101/236) of PVs. There was no ClinVar entry for 14% (17/125) of unique PVs, and 57% (111/196) of unique VUS. The area under the ROC curve for BRCAPRO was 0.76. In summary, we implemented a low-cost BRCA testing strategy and documented a significant burden of non-ClinVar reported BRCA PVs among Latin Americans. There are recurrent, population-specific PVs and CNVs, and we note that the BRCAPRO mutation probability model performs adequately. This study helps address the gap in our understanding of BRCA-associated cancer in Latin America.

scholarly journals Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network

2017 ◽  
Vol 216-217 ◽  
pp. 111-119 ◽  
Author(s):  
Thomas Slavin ◽  
Susan L. Neuhausen ◽  
Christina Rybak ◽  
Ilana Solomon ◽  
Bita Nehoray ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Genomics ◽  
Cancer Susceptibility ◽  
Research Network ◽  
Community Research ◽  
Clinical Cancer

No Longer Overlooked and Undervalued? The Evolving Dynamics of Endogenous Educational Research in Sub-Saharan Africa

2006 ◽  
Vol 76 (1) ◽  
pp. 80-109 ◽  
Author(s):  
RICHARD MACLURE
Keyword(s):  
International Development ◽  
Educational Research ◽  
Central Africa ◽  
Research Capacity ◽  
The United States ◽  
Sub Saharan Africa ◽  
Research Network ◽  
Research Networks ◽  
Sub Saharan ◽  
Local Research

Multilateral donors like the World Bank and bilateral agencies such as the United States Agency for International Development (USAID) and the British Department for International Development exert a great deal of influence in international educational development — particularly in sub-Saharan Africa — both in the programs they fund and the types of research they engage in. In this article, Richard Maclure investigates educational research in Africa and juxtaposes research done by large, exogenous, Western, results-oriented organizations with research performed by smaller, endogenous, local researchers aided by local research networks. Maclure argues convincingly that research that falls into the exogenous "donor-control" paradigm far too often is irrelevant to the African educational policy context and does little to develop local research capacity. The cases of two African research networks — the Educational Research Network of West and Central Africa and the Association for the Development of Education in Africa—are presented as exemplars of organizations that promote an alternative type of research that is endogenous, relevant to policy and the process of policymaking, and controlled by Africans. Maclure concludes with a call for increased support for and development of these types of networks, and for the development of the long-term solution to educational research in Africa — the university.

scholarly journals Developing a patient-driven chronic obstructive pulmonary disease (COPD) research agenda in the U.S.

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Inga Gruß ◽  
Gretchen M. McCreary ◽  
Ilya Ivlev ◽  
Mary Ellen Houlihan ◽  
Barbara P. Yawn ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Research Agenda ◽  
Well Being ◽  
Research Network ◽  
Community Research ◽  
Baseline Survey ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Survey Responses

Abstract Background To document a generalizable process for developing a patient-prioritized chronic obstructive pulmonary disease (COPD) research agenda and to provide an overview of domains that were developed in response to people living with COPD and caregivers’ suggestions for research. Methods Adults with COPD and caregivers who are members of the COPD Patient-Powered Research Network (PPRN) provided suggestions for COPD-related research through a self-administered, online survey. These responses were analyzed with a content analysis approach: domains for categorizing all survey responses were created, then all responses were categorized independently by a group of researchers, then these categorizations were adjudicated, and finally a density map was created that represented the number of responses in each of the domains. Results At the time of analysis, 6157 adults had fully completed the baseline survey. Survey responses were categorized across seven domains as follows: 22.5% of all responses fell into the domain family/social/community research, 20.8% of all responses fell into the domain well-being, 15% of all responses fell into the domain curative research, 14.6% of all responses fell into the domain biomedical therapies, 10.5% of all responses fell into the domain policy concerns, 6% of all responses fell into the domain holistic therapies and 10.7% of all responses fell into the domain ambiguous comments that could not be translated into concrete research topics. Conclusion Using qualitative open-ended survey responses from the COPD PPRN registrants, we were able to identify six key domains of research about COPD that are considered most important by patients. These domains differ in content from prior scientist-led efforts to develop priorities for COPD research, demonstrating the ongoing importance of involving patients and their caregivers in determining research priorities. The results suggest the field can more closely align research efforts to patient priorities by considering the identified domains.

scholarly journals Overlapping Climate Clubs: Self-Enforcing R&D Networks to Mitigate Global Warming

Games ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 4
Author(s):  
Emilson Caputo Delfino Silva ◽  
Chikara Yamaguchi
Keyword(s):  
Climate Change ◽  
Carbon Capture ◽  
Carbon Capture And Storage ◽  
Free Riding ◽  
Global Network ◽  
Research Network ◽  
Research Networks ◽  
Hub And Spoke ◽  
Control Climate ◽  
And Storage

Free riding incentives make it difficult to control climate change. To improve the chances of the Paris Agreement’s ambitious goal, many nations are forming scientific networks in carbon capture and storage (CCS). These networks take many forms (bilateral, hub-and-spoke, and multilateral). Studies of social interactions among scientists demonstrate that research networks are limited because of relational issues, such as lack of trust. This paper provides a rationale for the formation of various types of international CCS networks and examines their impacts on climate change. Our concept of stability focuses on Nash equilibria that are immune to coalitional deviations in overlapping networks. Players may belong to various research networks. A particular research network is a climate club. We show that in the absence of top-down coordination in clubs, the type of global network that forms depends on relational attrition. The complex task is to mitigate free riding while enhancing trust.

scholarly journals Understanding the Global Status of Particulate Matter with Respect to Research Topics and Research Networks

2019 ◽  
Vol 11 (20) ◽  
pp. 5594
Author(s):  
Kayoung Kim ◽  
Young Ho Byun ◽  
Donghyuk Lee ◽  
Noeon Park
Keyword(s):  
Particulate Matter ◽  
South Korea ◽  
Power Plants ◽  
Topic Model ◽  
Developed Countries ◽  
Research Network ◽  
Research Networks ◽  
Research Topics ◽  
The Usa ◽  
D Investment

Atmospheric pollution caused by particulate matter (PM), which has been identified as a carcinogen, is a major concern in South Korea, with various PM emission sources identified, including vehicles and power plants. The Korean government recently announced plans to increase research and development (R&D) expenditure to reduce PM levels in the atmosphere. In this study, the research topics and research networks for PM technology are summarized to help policymakers to more efficiently plan future R&D investment. A topic model is implemented to identify the main keywords from Science Citation Index (SCI) papers related to PM, and social network analysis is used to understand research collaboration between different countries or institutions. The results reveal that China and the USA published the largest number of SCI papers related to PM research, while South Korea was ranked in the top five globally. Unlike China and South Korea, developed countries such as the USA, Germany, and France have been carrying out PM research on climate change, ozone, NH3, nanoparticles, and the health effects on pregnant women. The primary research networks are centered on China and the USA, while South Korea has weak collaboration with other countries or institutions. More effort is thus required to improve strategic R&D investment and the research network within Korea.

scholarly journals An Exploratory Study of Accomplished Librarian-Researchers

2020 ◽  
Vol 15 (1) ◽  
pp. 179-217
Author(s):  
Marie R. Kennedy ◽  
Kristine R. Brancolini ◽  
David P. Kennedy
Keyword(s):  
Professional Training ◽  
Success Factors ◽  
Research Output ◽  
Work Conditions ◽  
Research Process ◽  
Research Network ◽  
Research Networks ◽  
Research Environments ◽  
Institutional Expectations ◽  
Potential Factors

Abstract Objective – This work explores potential factors that may contribute to a librarian becoming a highly productive researcher. An understanding of the factors can provide evidence based guidance to those at the beginning of their research careers in designing their own trajectories and to library administrators who seek to create work conditions that contribute to librarian research productivity. The current study is the first to explore the factors from the perspective of the profession’s most accomplished librarian-researchers. Methods – This exploratory and descriptive study recruited 78 academic librarians identified as highly productive researchers; 46 librarians participated in a survey about their professional training and research environments, research networks, and beliefs about the research process. Respondents supplied a recent CV which was coded to produce a research output score for the past 10 years. In addition to fixed-response questions, there were five open-ended questions about possible success factors. All data were analyzed with descriptive statistics and tests of significance correlations. Results – Accomplished librarian-researchers have professional training backgrounds and research environments that vary widely. None is statistically associated with research output. Those with densely connected networks of research colleagues who both know each other and do research together is significantly related to research output. A large group of those identified in the research networks are “both friend and colleague” and offer each other reciprocal support. In open-ended questions, respondents mentioned factors that equally span the three categories of research success: individual attributes, peers and community, and institutional structures. Conclusion – The authors found that that there are many paths to becoming an accomplished librarian-researcher and numerous factors are conducive to achieving this distinction. A positive research environment includes high institutional expectations; a variety of institutional supports for research; and extrinsic rewards, such as salary increases, tenure, promotion, and opportunities for advancement. The authors further conclude that a librarian’s research network may be an important factor in becoming an accomplished librarian-researcher. This finding is supported by both the research network analysis and responses to open-ended questions in which collaboration was a frequent theme.

Growth in head and neck cancer clinical research in the NCRN and NCRI: Expanding opportunities for patients across the United Kingdom.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e16007-e16007
Author(s):  
Matthew T. Seymour ◽  
Rachel Moser ◽  
Matthew Cooper ◽  
Sheila Fisher ◽  
Karen Poole ◽  
...  
Keyword(s):  
Cancer Research ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Clinical Studies ◽  
Network Activity ◽  
Research Network ◽  
Treatment Modalities ◽  
Research Networks ◽  
Incident Cases

e16007 Background: The National Institute for Health Research Cancer Research Network (NCRN) was established in 2001 to benefit patients by improving the coordination, integration and speed of cancer research. Networks were established in England (NCRN), Scotland, Wales and Northern Ireland, supporting recruitment to a national portfolio across the NHS. In a decade recruitment to cancer studies has increased five fold in England to 20% of new incident cases. Head and Neck cancers affect basic functions including breathing and eating; particularly devastating for patients. The NCRI Head and Neck Cancer Clinical Studies Group is one of 23 Groups funded by NCRI members with a UK wide remit to develop a national portfolio of clinical studies. All CSGs include patients and carers as members resulting in active patient involvement in trial design, patient information and strategic direction of the portfolio. Methods: The last decade has seen unprecedented growth in the Head and Neck portfolio, which now includes 43 studies from only three studies in 2003/4. By 2010/11, 95% of UK Cancer Local Research Networks (37 networks) were recruiting to Head and Neck studies from only 2 networks in 2001/2, expanding trial access for patients and developing Head and Neck research expertise in new sites and with new investigators. Results: Numbers of patients participating in Head and Neck studies has grown exponentially. Since 2006/7 UK patient recruitment has risen 15-fold from 126 to 1890, representing almost 25% new incident cases of Head and Neck cancer. Conclusions: Rapid portfolio growth and associated network activity has expanded opportunities for patients with Head and Neck cancer; providing access to new therapeutic agents and treatment modalities, including NIHR CRN-adopted commercial trials and studies in a surgical setting. Participation in studies demonstrating the effectiveness of Intensity Modulated Radiotherapy in reducing xerostomia (including PARSPORT), has supported integration of this technique into cancer service.

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