ESD Test Models and Standards

2021 ◽  
pp. 51-76
Keyword(s):  
Test Models

Defibrotide Inhibits Platelet Activation by Cathepsin G Released From Stimulated Polymorphonuclear Leukocytes

1992 ◽  
Vol 67 (06) ◽  
pp. 660-664 ◽  
Author(s):  
Virgilio Evangelista ◽  
Paola Piccardoni ◽  
Giovanni de Gaetano ◽  
Chiara Cerletti
Keyword(s):  
Platelet Activation ◽  
Polymorphonuclear Leukocytes ◽  
Direct Interaction ◽  
Cathepsin G ◽  
In Vivo Test ◽  
Cell Functions ◽  
Test Models ◽  
Antithrombotic Effects

SummaryDefibrotide is a polydeoxyribonucleotide with antithrombotic effects in experimental animal models. Most of the actions of this drug have been observed in in vivo test models but no effects have been reported in in vitro systems. In this paper we demonstrate that defibrotide interferes with polymorphonuclear leukocyte-induced human platelet activation in vitro. This effect was not related to any direct interaction with polymorphonuclear leukocytes or platelets, but was due to the inhibition of cathepsin G, the main biochemical mediator of this cell-cell cooperation. Since cathepsin G not only induces platelet activation but also affects some endothelial cell functions, the anticathepsin G activity of defibrotide could help to explain the antithrombotic effect of this drug.

UJI TARIK HIDRODINAMIKMODEL KAPAL BERSAYAP WiSE DENGAN LAMBUNG DASAR BERSTEP

2013 ◽  
Vol 12 (3) ◽  
Author(s):  
Iskendar Iskendar ◽  
Andi Jamaludin ◽  
Paulus Indiyono
Keyword(s):  
Comparative Study ◽  
Model Test ◽  
Hydrodynamic Model ◽  
Surface Effect ◽  
Center Of Gravity ◽  
Test Results ◽  
Flat Bottom ◽  
Towing Tank ◽  
Test Models ◽  
Wetted Surface Area

This paper describes hydrodynamic model tests of Wing in Surface Effect (WiSE) Craft. These craft  was fitted with  stephull  form in different location on longitudinal flat bottom (stepedhull planning craft) to determine the influences of sticking and porpoising motion performances. These motions are usually occured when the craft start to take-off from water surfaces. The test models with scale of 1 : 7 were comprised of 4 (four) stephull models and 1 (one) non-stephull model  as a comparative study. The hydrodynamic  tests were performed with craft speed of 16 – 32 knots (prototype values) in Towing Tank at UPT. Balai Pengkajian dan Penelitian Hidrodinamika (BPPH), BPPT, Surabaya. The resistance (drag) was measured by dynamo meter and the trim of model (draft changing at fore and aft  of model due to model speed) was measured by trim meter. By knowing the value of model trim, the wetted surface area can be determined. Then, the lift forces were calculated based on these measured values. The model test results were presented on tables and curves.  Test results show that models  with step located far away from center of gravity of the WiSE craft tend to porpoising and sticking condition, except if the step location on the below of these center of gravity. While model without step tends to sticking conditions.

Main topics and recent experiences for environmental monitoring and modelling diffuse pollution

1996 ◽  
Vol 33 (4-5) ◽  
pp. 63-72
Author(s):  
Federico Preti
Keyword(s):  
Groundwater Contamination ◽  
Scientific Literature ◽  
Practical Experience ◽  
Field Monitoring ◽  
Research Field ◽  
Scale Model ◽  
Nonpoint Pollution ◽  
Nonpoint Sources ◽  
Test Models ◽  
Basin Scale

Monitoring and modelling are two complementary instruments necessary for the analysis of pollution phenomena, such as groundwater contamination and lakes eutrophication, often generated by diffuse (nonpoint) sources (NPS). A review of scientific literature has been conducted to obtain the information necessary to develop a correct methodology relative to environmental field monitoring and modelling agricultural nonpoint pollution. A questionnaire has been handed out to several researchers who are involved in this research field in order to learn of other pertinent activities being undertaken and to facilitate the exchange of information. Testing and verification of a methodology for the analysis of contamination caused by the use of agrochemicals, based on field monitoring studies and the application of a distributed nonpoint pollution model, have been conducted in Italy. Based on the research developed and practical experience, some of the main guidelines for conducting studies of pollution processes caused by agriculture as well as a summary of theoretical and practical aspects encountered in the design of field and basin scale model validation studies and in the use of published experimental results to test models can be proposed.

The struggle with rheumatism through Dracunculus vulgaris Schott: In the light of ethnobotanical information.

2020 ◽  
Vol 13 ◽  
Author(s):  
Fatma Tuğçe Gürağaç Dereli ◽  
Mert Ilhan ◽  
Esra Küpeli Akkol
Keyword(s):  
Petroleum Ether ◽  
Inflammatory Diseases ◽  
Petroleum Ether Extract ◽  
Major Constituent ◽  
Control Group ◽  
Ether Extract ◽  
Test Models ◽  
Mouse Ear ◽  
Gas Chromatography Mass Spectroscopy ◽  
Abdominal Constriction

Background: The fruits with the seeds of Dracunculus vulgaris Schott. (Araceae) are used against inflammatory diseases in Turkey. Objective: Present study was designed to justify this folkloric usage type of the plant. Therefore, the aim of this study is to investigate the anti-inflammatory activity of D. vulgaris. Methods: Petroleum ether, ethyl acetate and methanol extracts were prepared from the fruits, successively. Carrageenan-, serotonin-, and prostaglandin E2-induced hind paw edema; acetic acid–induced capillary permeability and 12-O-tetradecanoyl-phorbol-13-acetate–induced mouse ear edema models were used to assess the antiinflammatory activity of the extracts. The analgesic activity was experienced by using p-benzoquinone-induced abdominal constriction test. Results: The petroleum ether extract displayed the highest activities in all of the used test models compared with the control group. Therefore, the constituents of this extract were determined by using gas chromatography–mass spectroscopy (GC–MS). Linoleic acid was found to be major constituent of the petroleum ether extract of D. vulgaris. Conclusion: This study has provided some justification for the folkloric use of the plant.

scholarly journals Exploration of in vitro thrombolytic, anthelminthic, cytotoxic and in vivo anxiolytic potentials with phytochemical screening of flowers of Brassica nigra

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohammad Sarowar Uddin ◽  
Md. Shalahuddin Millat ◽  
Mohammad Safiqul Islam ◽  
Md. Saddam Hussain ◽  
Md. Giash Uddin ◽  
...  
Keyword(s):  
Brassica Nigra ◽  
Anxiolytic Activity ◽  
Clot Lysis ◽  
Dependent Manner ◽  
Standard Drug ◽  
Lead Compounds ◽  
Lysis Activity ◽  
Test Models

Abstract Background Brassica nigra is a plant of Brassicaceae family, which possesses numerous medicinal values. Our present study is intended to assess the potential in vitro thrombolytic, anthelminthic, cytotoxic and in vivo anxiolytic properties of MCE of B. nigra flowers. MCE was fractioned for separating the compound on the basis of polarity by using chloroform, n-hexane and ethyl acetate solvent. Thrombolytic and anthelminthic activities were explained by collecting human erythrocytes and earthworms as test models, respectively. Anxiolytic activity was evaluated by elevated plus maze and hole board models while cytotoxic test was conducted through brine shrimp lethality bioassay. Results MCE revealed the presence of alkaloids, flavonoids, tannin, diterpenes, glycosides, carbohydrates, phenols, fixed oils and fat. In case of thrombolytic test, the MCE, CSF, ASF and n-HSF had produced maximum clot lysis activity at 5 and 10 mg/ml dose conditions. Two different concentrations (10 and 20 mg/ml) of MCE and its fractions showed significant (p < 0.05) anthelminthic activities in a dose-dependent manner. Significant anxiolytic activity was observed for all fractions which was comparable to the standard drug diazepam (p < 0.05). Again, the cytotoxic screening also presented good potentials for all fractions. Conclusion From the findings of present study, we can conclude that MCE of B. nigra flowers and its fraction possess significant anxiolytic, anthelmintic, anticancer and thrombolytic properties which may be a good candidate for treating these diseases through the determination of bio-active lead compounds.

scholarly journals Dimensional Accuracy of Dental Models for Three-Unit Prostheses Fabricated by Various 3D Printing Technologies

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1550
Author(s):  
Soo-Yeon Yoo ◽  
Seong-Kyun Kim ◽  
Seong-Joo Heo ◽  
Jai-Young Koak ◽  
Joung-Gyu Kim
Keyword(s):  
Surface Roughness ◽  
Three Dimensional ◽  
Dimensional Accuracy ◽  
3D Analysis ◽  
Digital Light Processing ◽  
Test Models ◽  
Reference File ◽  
Significant Difference ◽  
Jet Printing ◽  
3D Printed

Previous studies on accuracy of three-dimensional (3D) printed model focused on full arch measurements at few points. The aim of this study was to examine the dimensional accuracy of 3D-printed models which were teeth-prepped for three-unit fixed prostheses, especially at margin and proximal contact areas. The prepped dental model was scanned with a desktop scanner. Using this reference file, test models were fabricated by digital light processing (DLP), Multi-Jet printing (MJP), and stereo-lithography apparatus (SLA) techniques. We calculated the accuracy (trueness and precision) of 3D-printed models on 3D planes, and deviations of each measured points at buccolingual and mesiodistal planes. We also analyzed the surface roughness of resin printed models. For overall 3D analysis, MJP showed significantly higher accuracy (trueness) than DLP and SLA techniques; however, there was not any statistically significant difference on precision. For deviations on margins of molar tooth and distance to proximal contact, MJP showed significantly accurate results; however, for a premolar tooth, there was no significant difference between the groups. 3D color maps of printed models showed contraction buccolingually, and surface roughness of the models fabricated by MJP technique was observed as the lowest. The accuracy of the 3D-printed resin models by DLP, MJP, and SLA techniques showed a clinically acceptable range to use as a working model for manufacturing dental prostheses

scholarly journals Experimental Investigations on Ultimate Behavior of Fabricated Mobile Scaffolds

Metals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 851
Author(s):  
Heesoo Kim ◽  
Jeonghyeon Lim ◽  
Jeonghwa Lee ◽  
Young Jong Kang ◽  
Seungjun Kim
Keyword(s):  
Evaluation Methods ◽  
System Level ◽  
Structural Safety ◽  
Structural Performance ◽  
Experimental Investigations ◽  
Rigorous Evaluation ◽  
Effective Evaluation ◽  
Test Models ◽  
Behavior Characteristics ◽  
Structural Behaviors

A fabricated mobile scaffold has various components, including vertical members, horizontal members, braces, work plates, and castor wheels. In Korea, the structural performance of each member must be validated based on member-level structural safety criteria; this means that rigorous evaluation methods are required to secure the system-level structural safety of the fabricated mobile scaffold. To suggest rational system-level structural safety criteria and effective evaluation methods, the characteristics of the structural behaviors of the assembled structure must be investigated first. Unlike other temporary equipment, it is a product that requires convenience of use and ease of movement. Therefore, to secure the safety and usability of the structure, it is necessary to evaluate the ultimate behavior of a mobile scaffold fabricated with various material and structural types. In an experimental study, the ultimate mode and load-bearing capacity were investigated, and the appropriateness of the required performance of the mobile scaffold was reviewed. Three types of experimental test models with different materials (steel and aluminum) and stories (single-story and three-story erection) were selected and examined for vertical loads. Based on the experimental results, the ultimate behavior characteristics of the fabricated mobile scaffold were analyzed, and the ultimate load was identified.

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