The Initial Formation of the Skin Layer of PLGA Microparticles

2021 ◽  
pp. 2101427
Author(s):  
Farrokh Sharifi ◽  
Andrew Otte ◽  
Kinam Park
1964 ◽  
Vol 47 (1) ◽  
pp. 51-57 ◽  
Author(s):  
K.-O. Mosebach ◽  
W. Dirscherl

ABSTRACT The initial distribution of radioactive C was studied in the cell fractions of the liver, kidney, testes and thigh muscles after intraperitoneal injection of testosterone-4-14C into 40 day old male rats. To make this possible, the absolute and specific activity values (μc/mg C) were determined. After both ten and twenty minutes the cytoplasm fractions possessed the highest activity values, the only exception being the specific activity of the liver cytoplasm ten minutes after injection when the microsomes of the liver showed a higher activity. After 20 min the mitochondria possessed the highest specific activity values among the corpuscular fractions. The specific activity values in the microsomes of all four organs studied were lower 20 min after the time of injection than after 10 min, a fact, which is suspected to be the result of the initial formation of conjugates in the microsomes.


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2279-PUB ◽  
Author(s):  
ROSITA PRIMAVERA ◽  
MIRKO MAGNONE ◽  
DANIELE DI MASCOLO ◽  
ELENA ZOCCHI ◽  
ANGELO DE PASCALE ◽  
...  

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
María Isabel Orozco Rivero

La formación inicial del profesor de la Educación Técnica y Profesional (ETP), debe estar en correspondenciacon la integración del conocimiento científico, el acelerado desarrollo de la ciencia y la tecnologíay las exigencias en la formación de las nuevas generaciones. Esta investigación aborda la problemáticaplanteada en la formación de profesores para la Carrera de Informática y asume como problemacientífico: “¿Cómo contribuir al desarrollo de una cultura científica como base para una participaciónciudadana responsable, en la formación inicial del profesor para la ETP en la Carrera Informática?”. La metodología utilizada constituye una integración de métodos teóricos y empíricos, lo que permitióla elaboración de la propuesta. Se trabajan y sustentan los antecedentes teóricos y metodológicos delproceso de formación inicial del profesor para la Educación Técnica y Profesional. Finalmente, se brindan los resultados de la aplicación de la consulta a expertos como comprobación teórica del mismo ysu aplicación parcial en la práctica. El fundamento teórico y las relaciones sistemáticas que se establecenentre los componentes, constituyen el principal aporte teórico y novedad de la investigación.   Palabras Clave: participación ciudadana, cultura científica, formación inicial, educación técnica y profesional.   ABSTRACT   The basic formation of teachers in Technical and Professional Education (TPE) must be in correspondencewith the integration of scientific development, the accelerated development of science and technology, and the educational demands of the new generations.  This research addresses the stated problem in the formation of teachers for the Informatics Career and assumes the scientific problem: How to contribute to thedevelopment of a scientific culture as the basis of a responsible citizen participation, in the initial formation of the ETP teacher in the Informatics Career? The methodology used integrates both theoretical and empiricalmethods which helped to build up this proposal.  Historical and methodological background of the formation process are worked out and supported.  Finally, results of the application of expert consulting as averification in theory and practice. The theoretical foundations and the systematic relationships established among the components constitute the main theoretical contribution and novelty of this research.   Keywords: citizen participation, scientific culture, initial formation, technical and professional education   Recibido: julio de 2015Aprobado: septiembre de 2015


1997 ◽  
Vol 35 (8) ◽  
pp. 137-144 ◽  
Author(s):  
Tsuyoshi Nomura ◽  
Takao Fujii ◽  
Motoyuki Suzuki

Porous membrane of poly(tetrafluoroethylene) (PTFE) was formed on the surface of porous ceramic tubes by means of heat treatment of the PTFE particles deposit layer prepared by filtering PTFE microparticles emulsified in aqueous phase. By means of inert gas permeation, pore size was determined and compared with scanning electron micrograph observation. Also rejection measurement of aqueous dextran solutions of wide range of molecular weights showed consistent results regarding the pore size. Since the membrane prepared by this method is stable and has unique features derived from PTFE, it is expected that the membrane has interesting applications in the field of water treatment. Membrane separation of activated sludge by this composite membrane and original ceramics membrane showed that the PTFE membrane gives better detachability of the cake layer formed on the membrane. This might be due to the hydrophobic nature of the PTFE skin layer.


2020 ◽  
Vol 15 (4) ◽  
pp. 283-298
Author(s):  
Suresh Kumar Sahu ◽  
Rakesh Raj ◽  
Pooja Mongia Raj ◽  
Ram Alpana

Treatment of skin ailments through systemic administration is limited due to toxicity and patients discomfort. Hence, lower risk of systemic side effects from topical dosage forms like ointments, creams, emulsions and gels is more preferred for the treatment of skin disease. Application of lipid based carriers in drug delivery in topical formulations has recently become one of the major approaches to improve drug permeation, safety, and effectiveness. These delivery systems include liposomes, ethosomes, transfersomes, Nanoemulsions (NEs), Solid Lipid Nanoparticles (SLNs) Nanostructured Lipid Carriers (NLCs) and micelles. Most of the liposomes and SLNs based products are in the market while some are under investigation. Transcutaneous delivery of therapeutics to the skin layer by novel lipid based carriers has enhanced topical therapy for the treatment of skin ailments. This article covers an overview of the lipid-based carriers for topical uses to alleviate skin diseases.


2020 ◽  
Vol 14 (3) ◽  
pp. 169-186
Author(s):  
Marwa Emam ◽  
Akaber T. Keshta ◽  
Yasser M.A. Mohamed ◽  
Yasser A. Attia

Background: Wound healing is a complex process necessary for repairing damaged tissues and preventing infection. Selenium nanoparticles (Se NPs) were known due to their antioxidant and antimicrobial effects, also niacin has angiogenesis and antioxidant effects that are important in wound healing. Objective: The present study was conducted to investigate the effect of Se NPs and niacin in reducing and accelerating the wound healing time in mice. Methods: A simple wet chemical method has been modified to synthesize Se NPs in order to investigate their effect and niacin on reducing the wound healing in 80 adult female albino mice (250 mm2 full thickness open excision wound) that were divided into eight groups (10 mice/each). After 30-days, the mice were sacrificed, blood and tissue samples were taken for analysis. Results: The results showed that the percentage of wound area had been significantly reduced in Se NPs and niacin treated groups compared to the positive control. The level of Vascular Endothelial cell Growth Factor and Collagenase I in Se NPs and niacin groups significantly exceed those of other groups while Nitric Oxide (NO) was significantly decreased in treated groups. Liver and kidney functions showed the lower toxicity effect of Se NPs and niacin. Skin tissue showed the wound healing effect of Se NPs and niacin by regenerating skin layer compared to the positive group. Conclusion: Se NPs and niacin play an important role in accelerating and reducing the time of wound healing while they were antagonistic to each other.


2015 ◽  
Vol 18 (12) ◽  
pp. 1780-1788 ◽  
Author(s):  
Kenta M Hagihara ◽  
Tomonari Murakami ◽  
Takashi Yoshida ◽  
Yoshiaki Tagawa ◽  
Kenichi Ohki

2021 ◽  
pp. 096739112098650
Author(s):  
Dah Hee Kim ◽  
Young Seok Song

The purpose of this study is to integrate a polymeric film onto a mold to impede thermal heat transfer during resin infusion. A thin plastic plate was fabricated by using microinjection molding. A polyimide (PI) film was laminated onto a mold in an effort to produce a thin light guide plate (LGP). The film could decelerate the solidification of molten polymer in the cavity of mold and enhance the wall slip of resin on the mold. The insulation effect was modeled numerically. The surface roughness and pattern transfer characteristics of the LGP were evaluated. It was found that the fluidity of the resin increased due to the decreased skin layer during mold filling. The results showed that the strategy proposed in this study could help decrease the thickness of LGP effectively when manufacturing the part via injection molding.


2021 ◽  
Vol 62 ◽  
pp. 102361
Author(s):  
F.F.O. Sousa ◽  
J.S. Nojosa ◽  
C.A.A. Alencar ◽  
A.P.M.P. Alcantara ◽  
R.S. Araújo ◽  
...  

1986 ◽  
Vol 46 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Richard Haberman
Keyword(s):  

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