scholarly journals Drug Delivery: Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles (Adv. Mater. 21/2012)

2012 ◽  
Vol 24 (21) ◽  
pp. 2798-2798
Author(s):  
Xinjian Yang ◽  
Xia Liu ◽  
Zhen Liu ◽  
Fang Pu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Targeted Drug

Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles

2012 ◽  
Vol 24 (21) ◽  
pp. 2890-2895 ◽  
Author(s):  
Xinjian Yang ◽  
Xia Liu ◽  
Zhen Liu ◽  
Fang Pu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Targeted Drug

scholarly journals Near-Infrared Light-Responsive Core–Shell Nanogels for Targeted Drug Delivery

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 5094-5099 ◽  
Author(s):  
Huaizhi Kang ◽  
Anna Carolina Trondoli ◽  
Guizhi Zhu ◽  
Yan Chen ◽  
Ya-Jen Chang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Core Shell ◽  
Near Infrared Light ◽  
Targeted Drug

Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

2019 ◽  
Vol 34 (6) ◽  
pp. 875-888 ◽  
Author(s):  
Hui-Chao Lin ◽  
Wen-Tian Li ◽  
Thushara W Madanayake ◽  
Can Tao ◽  
Qiang Niu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Targeted Drug

Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

2016 ◽  
Vol 27 (13) ◽  
pp. 135102 ◽  
Author(s):  
Long Wan ◽  
Jian Jiao ◽  
Yu Cui ◽  
Jingwen Guo ◽  
Ning Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Carbon Nanoparticles ◽  
Mesoporous Carbon ◽  
Targeted Drug

scholarly journals Aptamer-modified polymer nanoparticles for targeted drug delivery

2016 ◽  
Vol 17 (1-2) ◽  
Author(s):  
Julia Modrejewski ◽  
Johanna-Gabriela Walter ◽  
Imme Kretschmer ◽  
Evren Kemal ◽  
Mark Green ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Mode Of Delivery ◽  
Delivery Systems ◽  
The Body ◽  
Lung Cancer Cells ◽  
Targeted Drug

AbstractThe purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often delivered unspecifically resulting in unwarranted adverse effects. To circumvent this problem, there is an increasing demand for the development of intelligent drug delivery systems allowing a tissue-specific mode of delivery. Within this study, nanoparticles consisting of two biocompatible polymers are used. Because of their small size, nanoparticles are well-suited for effective drug delivery. The small size affects their movement through cell and tissue barriers. Their cellular uptake is easier when compared to larger drug delivery systems. Paclitaxel was encapsulated into the nanoparticles as a model drug, and to achieve specific targeting an aptamer directed against lung cancer cells was coupled to the nanoparticles surface. Nanoparticles were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and nanotracking analysis (NTA). Also their surface charge was characterized from ζ-potential measurements. Their preparation was optimized and subsequently specificity of drug-loaded and aptamer-functionalized nanoparticles was investigated using lung cancer cells.

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