scholarly journals Functional connectivity is altered by APOE4 carrier status in cognitively healthy older adults

2021 ◽  
Vol 17 (S1) ◽  
Author(s):  
Zachary D. Green ◽  
Robyn A Honea ◽  
Eric D Vidoni ◽  
Jeffrey M. Burns ◽  
Jill K Morris
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Carrier Status ◽  
Healthy Older Adults ◽  
Apoe4 Carrier

scholarly journals Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers

2021 ◽  
pp. 1-11
Author(s):  
Kylie R. Kadey ◽  
John L. Woodard ◽  
Allison C. Moll ◽  
Kristy A. Nielson ◽  
J. Carson Smith ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Body Mass ◽  
Carrier Status ◽  
Healthy Older Adults ◽  
E4 Allele ◽  
Lifestyle Risk

Background: Body mass index (BMI) has been identified as an important modifiable lifestyle risk factor for dementia, but less is known about how BMI might interact with Apolipoprotein E ɛ4 (APOE ɛ4) carrier status to predict conversion to mild cognitive impairment (MCI) and dementia. Objective: The aim of this study was to investigate the interaction between APOE ɛ4 status and baseline (bBMI) and five-year BMI change (ΔBMI) on conversion to MCI or dementia in initially cognitively healthy older adults. Methods: The associations between bBMI, ΔBMI, APOE ɛ4 status, and conversion to MCI or dementia were investigated among 1,289 cognitively healthy elders from the National Alzheimer’s Coordinating Center (NACC) database. Results: After five years, significantly more carriers (30.6%) converted to MCI or dementia than noncarriers (17.6%), p <  0.001, OR = 2.06. Neither bBMI (OR = 0.99, 95%CI = 0.96–1.02) nor the bBMI by APOE interaction (OR = 1.02, 95%CI = 0.96–1.08) predicted conversion. Although ΔBMI also did not significantly predict conversion (OR = 0.90, 95%CI = 0.78–1.04), the interaction between ΔBMI and carrier status was significant (OR = 0.72, 95%CI = 0.53–0.98). For carriers only, each one-unit decline in BMI over five years was associated with a 27%increase in the odds of conversion (OR = 0.73, 95%CI = 0.57–0.94). Conclusion: A decline in BMI over five years, but not bBMI, was strongly associated with conversion to MCI or dementia only for APOE ɛ4 carriers. Interventions and behaviors aimed at maintaining body mass may be important for long term cognitive health in older adults at genetic risk for AD.

scholarly journals Resting state functional connectivity in early post-anesthesia recovery is characterized by globally reduced anticorrelations

2019 ◽  
Author(s):  
Tommer Nir ◽  
Yael Jacob ◽  
Kuang-Han Huang ◽  
Arthur E. Schwartz ◽  
Jess W. Brallier ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Resting State ◽  
Regions Of Interest ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
Healthy Human ◽  
Healthy Older Adults ◽  
Human Volunteers ◽  
Resting State Connectivity

ABSTRACTThough a growing body of literature is addressing the possible longer-term cognitive effects of anesthetics, to date no study has delineated the normal trajectory of neural recovery due to anesthesia alone in older adults. We obtained resting state functional magnetic resonance imaging scans on 62 healthy human volunteers between ages forty and eighty before, during, and after sevoflurane (general) anesthesia, in the absence of surgery, as part of a larger study on cognitive function post-anesthesia. Resting state networks expression decreased consistently one hour after emergence from anesthesia. This corresponded to a global reduction in anticorrelated functional connectivity post-anesthesia, seen across individual regions-of-interest. Positively correlated functional connectivity remained constant across peri-anesthetic states. All measures returned to baseline 1 day later, with individual regions-of-interest essentially returning to their pre-anesthesia connectivity levels. These results define normal peri-anesthetic changes in resting state connectivity in healthy older adults.

scholarly journals Effect of Acute Exercise on Salience Network Functional Connectivity and Affect in Healthy Older Adults

2018 ◽  
Vol 50 (5S) ◽  
pp. 629
Author(s):  
Alfonso J. Alfini ◽  
Lauren R. Weiss ◽  
Junyeon Won ◽  
Corey Michelson ◽  
Daniel Callow ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Acute Exercise ◽  
Salience Network ◽  
Healthy Older Adults

scholarly journals The independent influences of age and education on functional brain networks and cognition in healthy older adults

2017 ◽  
Author(s):  
Alistair Perry ◽  
Wei Wen ◽  
Nicole A. Kochan ◽  
Anbupalam Thalamuthu ◽  
Perminder S. Sachdev ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Cognitive Processes ◽  
Brain Networks ◽  
Later Life ◽  
Healthy Ageing ◽  
Resting State Functional Connectivity ◽  
Healthy Older Adults ◽  
Functional Brain ◽  
Functional Brain Networks

AbstractHealthy ageing is accompanied by a constellation of changes in cognitive processes and alterations in functional brain networks. The relationships between brain networks and cognition during ageing in later life are moderated by demographic and environmental factors, such as prior education, in a poorly understood manner. Using multivariate analyses, we identify three latent patterns (or modes) linking resting-state functional connectivity to demographic and cognitive measures in 101 cognitively-normal elders. The first mode (p=0.00043) captures an opposing association between age and core cognitive processes such as attention and processing speed on functional connectivity patterns. The functional subnetwork expressed by this mode links bilateral sensorimotor and visual regions through key areas such as the parietal operculum. A strong, independent association between years of education and functional connectivity loads onto a second mode (p=0.012), characterised by the involvement of key hub-regions. A third mode (p=0.041) captures weak, residual brain-behaviour relations. Our findings suggest that circuits supporting lower-level cognitive processes are most sensitive to the influence of age in healthy older adults. Education, and to a lesser extent, executive functions, load independently onto functional networks - suggesting that the moderating effect of education acts upon networks distinct from those vulnerable with ageing. This has important implications in understanding the contribution of education to cognitive reserve during healthy ageing.

Electroacupuncture Modulates Resting-State Functional Connectivity in the Default Mode Network for Healthy Older Adults

2019 ◽  
Vol 33 (2) ◽  
pp. 85-92
Author(s):  
Dong-qiong Fan ◽  
Hai-chao Zhao ◽  
Jing Sheng ◽  
Yun-rui Liu ◽  
Jing Yu
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Cognitive Performance ◽  
Default Mode Network ◽  
Community Dwelling ◽  
Control Group ◽  
Therapeutic Effects ◽  
Healthy Older Adults ◽  
Default Mode ◽  
Ventral Medial Prefrontal Cortex

Aging involves cognitive decline and prominent alterations in brain activity. Electroacupuncture (EA), a traditional Chinese medicine approach, is demonstrated to be effective in improving cognitive function of older adults. However, the specific neural mechanism underlying this modulation effect remains unclear. In this study, we used functional magnetic resonance imaging (fMRI) to investigate whether EA could improve cognitive performance of community-dwelling older adults and whether these potential improvements are associated with the EA-induced brain functional connectivity alterations. Thirty healthy older adults were recruited and randomly assigned to the EA group and the control group. Behaviorally, we observed an EA-induced improvement in cognitive performance of older adults in the Montreal Cognitive Assessment. On a neural perspective, the EA intervention significantly increased the functional connectivity within the default mode network. Moreover, we found a positive association between the improvement in delayed memory performance and the alterations in the ventral medial prefrontal cortex-hippocampal formation connectivity in the EA group. This study extends previous findings by showing that healthy older adults exhibit neural plasticity manifested as increased functional connectivity after EA sessions, which could induce therapeutic effects in the treatment of neurodegenerative diseases.

scholarly journals 2038 Effects of bilateral frontal transcranial direct current stimulation (tDCS) on the working memory network: An fMRI-tDCS study in healthy older adults

2018 ◽  
Vol 2 (S1) ◽  
pp. 11-11
Author(s):  
Nicole R. Nissim ◽  
Andrew O’Shea ◽  
Lindsey Richards ◽  
Rachel Telles ◽  
Eric Porges ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Functional Connectivity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Memory Task ◽  
Healthy Older Adults ◽  
Direct Current Stimulation ◽  
Memory Network ◽  
Back Task

OBJECTIVES/SPECIFIC AIMS: The study aimed to determine the effects of bilateral frontal active transcranial direct current stimulation (tDCS) at 2 mA for 12 minute Versus sham stimulation on functional connectivity of the working memory network during an fMRI N-Back task. METHODS/STUDY POPULATION: Stimulation was delivered over bilateral frontal dorsolateral prefrontal cortex via and MRI-compatible tDCS device during an fMRI working memory task in healthy older adults in a within-subject design. RESULTS/ANTICIPATED RESULTS: Active stimulation compared with sham resulted in significant increases in functional connectivity in working memory related brain regions during the N-Back task. DISCUSSION/SIGNIFICANCE OF IMPACT: Older adults typically have reduced functional connectivity compared with young adults. Our findings demonstrate that a single session of tDCS can increase functional connectivity of the working memory network in older adults. Based on this mechanism of effect, tDCS may serve as an adjunctive method for interventions aiming to enhance cognitive processes in older adults.

scholarly journals Alertness Training Increases Visual Processing Speed in Healthy Older Adults

2021 ◽  
pp. 095679762096552
Author(s):  
Melanie D. Penning ◽  
Adriana L. Ruiz-Rizzo ◽  
Petra Redel ◽  
Hermann J. Müller ◽  
Tiina Salminen ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Processing Speed ◽  
Visual Processing ◽  
Training Group ◽  
Control Group ◽  
Significant Group ◽  
Healthy Older Adults ◽  
Visual Processing Speed ◽  
Individual Training

In this study, we investigated whether alertness training in healthy older adults increases visual processing speed (VPS) and whether functional connectivity in the cingulo-opercular network predicts training gain. Using the theory of visual attention, we derived quantitative estimates of VPS before and after training. In Study 1, 75 healthy older adults participated in alertness training, active-control training, or no training ( n = 25 each). A significant Group × Session interaction indicated an increase in VPS in the alertness-training group but not in the control group, despite VPS not differing significantly between groups before training. In Study 2, 29 healthy older adults underwent resting-state functional MRI and then participated in alertness training. Pretraining functional connectivity in the cingulo-opercular network correlated with the individual training-induced change in VPS. In conclusion, results indicate that alertness training improves visual processing in older adults and that functional connectivity in the cingulo-opercular network provides a neural marker for predicting individual training gain.

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