Late‐life physical activity relates to brain tissue synaptic integrity markers in older adults

2022 ◽  
Author(s):  
Kaitlin Casaletto ◽  
Alfredo Ramos‐Miguel ◽  
Anna VandeBunte ◽  
Molly Memel ◽  
Aron Buchman ◽  
...  
PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253484
Author(s):  
Robert J. Dawe ◽  
Lei Yu ◽  
Sue E. Leurgans ◽  
Bryan D. James ◽  
Victoria N. Poole ◽  
...  

Objective To test whether postmortem MRI captures brain tissue characteristics that mediate the association between physical activity and cognition in older adults. Methods Participants (N = 318) were older adults from the Rush Memory and Aging Project who wore a device to quantify physical activity and also underwent detailed cognitive and motor testing. Following death, cerebral hemispheres underwent MRI to quantify the transverse relaxation rate R2, a metric related to tissue microstructure. For analyses, we reduced the dimensionality of the R2 maps from approximately 500,000 voxels to 30 components using spatial independent component analysis (ICA). Via path analysis, we examined whether these R2 components attenuated the association between physical activity and cognition, controlling for motor abilities and indices of common brain pathologies. Results Two of the 30 R2 components were associated with both total daily physical activity and global cognition assessed proximate to death. We visualized these components by highlighting the clusters of voxels whose R2 values contributed most strongly to each. One of these spatial signatures spanned periventricular white matter and hippocampus, while the other encompassed white matter of the occipital lobe. These two R2 components partially mediated the association between physical activity and cognition, accounting for 12.7% of the relationship (p = .01). This mediation remained evident after controlling for motor abilities and neurodegenerative and vascular brain pathologies. Conclusion The association between physically activity and cognition in older adults is partially accounted for by MRI-based signatures of brain tissue microstructure. Further studies are needed to elucidate the molecular mechanisms underlying this pathway.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S429-S430
Author(s):  
Patricia M Bamonti ◽  
Jonathan Bean

Abstract Mobility disability is associated with considerable morbidity and mortality in late life. Physical activity [PA] is a modifiable behavior that can reduce mobility disability, as well as improve physical and mental health outcomes in older adults. However, only a minority of older adults meet the minimum PA requirements based on national guidelines. Research examining factors impacting PA and mobility in late life, as well as novel interventions to increase PA and improve mobility is essential to enhancing health and wellbeing. This symposium will provide an overview of observational and intervention research focused on understanding factors associated with PA and mobility, as well as intervention research designed to increase PA and improve mobility in older adults. First, Dr. Lien Quach will present research examining the impact of social engagement in reducing the risk of mobility decline among older adults with mild cognitive impairment. Second, Dr. Patricia Bamonti will examine psychological factors related to uptake and adherence of pulmonary rehabilitation in older Veterans. Third, Dr. Stephanie Robinson will explore engagement, feasibility, acceptability, and change in PA following a web-based intervention in middle-aged and older adult patients with COPD. Fourth, Dr. Elisa Ogawa will present research examining the feasibility and acceptability of an exergaming intervention compared to an exercise control condition among older adults at risk for falls. The symposium will conclude with discussion led by Jonathan Bean, MD, MPH, who will highlight implications of findings across studies and identify areas for future research.


2021 ◽  
Vol 14 (3) ◽  
pp. 1-28
Author(s):  
Dimitri Vargemidis ◽  
Kathrin Gerling ◽  
Vero Vanden Abeele ◽  
Luc Geurts ◽  
Katta Spiel

Wearable activity trackers are routinely applied in physical activity (PA) interventions in late life, but there is little research that focuses on older adults' perspectives on the technology. We conducted a qualitative study with 24 older persons to explore their perspective on wearables and PA. First, we discussed their relationship with PA and wearable trackers during focus groups. Next, nine participants crafted prototypes for wearables during co-design sessions. Through Thematic Analysis, we identified two main themes: (1) PA is personal in terms of preferred activities and reasons for PA, and (2) wearables are an emotional technology, causing negative emotions when resembling medical trackers or pressurizing to perform. We followed upon these results through a survey with 41 participants, which further highlighted individual differences in the perception of wearables. We conclude with questions to guide the design of wearables and reflect on their role to support PA in late life.


2021 ◽  
pp. JN-RM-1483-21
Author(s):  
Kaitlin B. Casaletto ◽  
Cutter A. Lindbergh ◽  
Anna VandeBunte ◽  
John Neuhaus ◽  
Julie A. Schneider ◽  
...  

GeroPsych ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 67-76
Author(s):  
Grace C. Niu ◽  
Patricia A. Arean

The recent increase in the aging population, specifically in the United States, has raised concerns regarding treatment for mental illness among older adults. Late-life depression (LLD) is a complex condition that has become widespread among the aging population. Despite the availability of behavioral interventions and psychotherapies, few depressed older adults actually receive treatment. In this paper we review the research on refining treatments for LLD. We first identify evidence-based treatments (EBTs) for LLD and the problems associated with efficacy and dissemination, then review approaches to conceptualizing mental illness, specifically concepts related to brain plasticity and the Research Domain Criteria (RDoc). Finally, we introduce ENGAGE as a streamlined treatment for LLD and discuss implications for future research.


2013 ◽  
Author(s):  
Sarah E. Nolan ◽  
Carolyn M. Tucker ◽  
Tasia M. Smith ◽  
Frederic D. Desmond

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