Designing of Biodegradable Interpenetrating Polymer Network of Poly(vinyl alcohol-co-acrylic acid)/sodium chloride hydrogel : An Approach to Drug Delivery

1970 ◽  
Vol 1 (2) ◽  
pp. 144-151
Author(s):  
Debajyoti Ray ◽  
Prafulla Kumar Sahoo ◽  
Guru Prasad Mohanta
Keyword(s):  
Drug Delivery ◽  
Thermal Stability ◽  
Sodium Chloride ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Electron Microscopic ◽  
Swelling Properties ◽  
Scanning Electron Microscopic Study ◽  
Thermal Stability Of

Interpenetrating polymer network (IPN) hydrogel based on polyvinyl alcohol (PVA) networking with polyacrylic acid (PAA), generated insitu, were prepared by without any added crosslinker, using benzoyl peroxide an initiator and sodium chloride (NaCl) as additive. The response of the hydrogels with and without NaCl was observed by studying their swelling behavior, biodegradability and thermal stability. Scanning electron microscopic study revealed that the pores of the prepared IPN were mostly open in presence of NaCl, thus making the hydrogel macroporous. (PVA-co-PAA)/NaCl was found to be more biodegradable than without NaCl. The IPN hydrogel showed comparatively higher swelling at intestinal pH than that of gastric medium and presence of NaCl in the IPN increases the swelling properties in both media. Thermal stability of IPN was affected by copolymerization, due to increasing porosity of the IPN. The prepared nontoxic, hydrophilic IPN hydrogel system holds good for further drug delivery studies in connection to its superswelling and biodegradablity.

scholarly journals Mechanical, thermal and surface properties of polyacrylamide/dextran semi-interpenetrating network hydrogels tuned by the synthesis temperature

2013 ◽  
Vol 11 (2) ◽  
pp. 248-258 ◽  
Author(s):  
Maria Dinu ◽  
Maria Cazacu ◽  
Ecaterina Drăgan
Keyword(s):  
Thermal Stability ◽  
Polymer Network ◽  
Synthesis Temperature ◽  
Water Vapor Sorption ◽  
Interpenetrating Polymer Network ◽  
Vapor Sorption ◽  
Interpenetrating Network ◽  
Preparation Temperature ◽  
Thermal Stability Of ◽  
Network Morphology

AbstractThe mechanical, rheological, thermal, and surface behaviors of three polyacrylamide/dextran (PAAm/Dx) semi-interpenetrating polymer network (semi-IPN) hydrogels, prepared at 22°C, 5°C and −18°C, were investigated. The results were compared with those obtained on cross-linked PAAm without Dx synthesized under the same conditions. Hydrogels prepared at the lowest temperature were the most mechanically stable. The thermal stability of the semi-IPN hydrogels is slightly lower than the corresponding PAAm gels, irrespective of preparation temperature. The water vapor sorption capacity depended on the presence of Dx as well as preparation temperature, which determines the network morphology.

scholarly journals Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Jingqiong Lu ◽  
Yinhui Li ◽  
Deng Hu ◽  
Xiaoling Chen ◽  
Yongmei Liu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Aspartic Acid ◽  
Vinyl Alcohol ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Simulated Gastric Fluid ◽  
Poly Vinyl Alcohol ◽  
Simulated Intestinal Fluid ◽  
Swelling Properties ◽  
Drug Controlled Release

Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

Synthesis and Properties of Thermo- and pH-Responsive PVA/P(DEA-co-MAA) Intelligent Semi-IPN Hydrogels

2012 ◽  
Vol 466-467 ◽  
pp. 229-233
Author(s):  
Nai Yan Zhang ◽  
Jiang Yu ◽  
Shou Jun Cai
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Radical Copolymerization ◽  
Unique Property ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Ph Responsive ◽  
Free Radical Copolymerization

A series of temperature- and pH-responsive poly(vinyl alcohol)/poly(N, N-diethylacrylamide-co-methacrylic acid) PVA/P(DEA-co-MAA) intelligent semi-IPN hydrogels were synthesized by free-radical copolymerization techniques and semi-interpenetrating polymer network techniques. The effects of the feed components, temperature and pH on the swelling behavior of the hydrogels were studied in detail. This unique property makes them very useful for biomedical applications such as on-off switches for modulated drug delivery and tissue engineering. With the increase of PVA content, the thermo- and pH-responsive of the semi-IPN hydrogel improved.

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