Physicochemical Characterization of Hizikia fusiforme Polysaccharide and Its Hypoglycemic Activity via Mediating Insulin‐Stimulated Blood Glucose Utilization of Skeletal Muscle in Type 2 Diabetic Rats

2020 ◽  
Vol 17 (10) ◽  
Author(s):  
Rui‐Bo Jia ◽  
Zhao‐Rong Li ◽  
Zhi‐Rong Ou ◽  
Juan Wu ◽  
Baoguo Sun ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Glucose ◽  
Glucose Utilization ◽  
Physicochemical Characterization ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Hizikia Fusiforme ◽  
Type 2 Diabetic

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

2020 ◽  
Vol 20 (7) ◽  
pp. 1117-1132
Author(s):  
Abdelaziz M. Hussein ◽  
Elsayed A. Eid ◽  
Ismaeel Bin-Jaliah ◽  
Medhat Taha ◽  
Lashin S. Lashin
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetic Cardiomyopathy ◽  
Caspase 3 ◽  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Control Group ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic

Background and Aims: In the current work, we studied the effects of exercise and stevia rebaudiana (R) extracts on diabetic cardiomyopathy (DCM) in type 2 diabetic rats and their possible underlying mechanisms. Methods: : Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal control group, b) DM group, type 2 diabetic rats received 2 ml oral saline daily for 4 weeks, c) DM+ Exercise, type 2 diabetic rats were treated with exercise for 4 weeks and d) DM+ stevia R extracts: type 2 diabetic rats received methanolic stevia R extracts. By the end of the experiment, serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative stress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression of p53, caspase-3, α-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues were measured. Results: T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and LDH, myocardial damage and fibrosis, myocardial MDA, myocardial α-SMA, p53, caspase-3, Nrf2 and TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p< 0.05). On the other hand, treatment with either exercise or stevia R extracts significantly improved all studied parameters (p< 0.05). Moreover, the effects of stevia R was more significant than exercise (p< 0.05). Conclusion: Both exercise and methanolic stevia R extracts showed cardioprotective effects against DCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these lines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density and fibrosis and upregulation of the antioxidant transcription factor, Nrf2.

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

scholarly journals EFFECT OF THE AQUEOUS EXTRACT OF CLERODENDRUM THOMSONIAE LINN (VERBENACEAE) LEAVES ON TYPE 2 DIABETIC WISTAR RATS INDUCED BY THE MACAPOS1 TYPE DIET AND DEXAMETHASONE

2021 ◽  
Author(s):  
Eric Martial Deutchoua Ngounou ◽  
Yannick Dimitry Mang ◽  
Faustin Dongmo ◽  
Oumar Waassili Ibrahim Malla ◽  
Sélestin Sokeng Dongmo ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Peer Review ◽  
Aqueous Extract ◽  
Reduction Rate ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Type 2 Diabetic

Aim and objective: Clerodendrum thomsoniae leaves are used in Cameroon to manage diabetes and its related disorders. The study aimed at investigating the antidiabetic effect of the aqueous extract on diet and dexamethasone induced diabetic rats. Methods: Young mature leaves of C thomsoniae were dried, finely powdered and submitted to aqueous extraction. The dehydrated extract was tested in rats at 3 doses 312.5, 625 and 1250 mg/kg based on the local use of the plant. The effect of the extract on the fasting blood glucose in normoglycemic rats and MACAPOS 1 type diet induced diabetic rats, using respectively glibenclamide and metformin as positive control groups, were investigated. Results: AECT significantly reduced blood glucose levels in normoglycemic rats (p<0.05) two hours after administration, from 83±2 mg/dL to 57.39±1.7 mg/dL with the dose of 1250 mg/kg. given the highest reduction rate of 30.86%. In normoglycemic rats 30 minutes after oral glucose overload, the maximum reduction rate was observed with glibenclamide 5 mg / kg and calculated at 49.90% followed by 36.39%, for the extract at 1250 mg / kg. After 30 days of repeated oral administration, AECT produced a reduction on blood glucose levels (p<0.05) in type 2 diabetic rats. This reduction in blood sugar was much more expressed with the dose of 1250mg/kg (73.52±0.71 mg/dL) followed by metformin 38mg/kg (70.21±0.89 mg/dL) as the normal control with no significant difference (P < 0.05). Conclusion: These results show that the antidiabetic activity of AECT can be explained by insulin stimulating effect, also give support to the traditional use of this plant.                   Peer Review History: Received 11 May 2021; Revised 17 June; Accepted 27 June, Available online 15 July 2021 Academic Editor: Dr. Asia Selman Abdullah,  Al-Razi university, Department of Pharmacy, Yemen, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. Terhemen Festus Swem, Department of Veterinary Physiology and Biochemistry, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria, [email protected] Taha A.I. El Bassossy, Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt, [email protected] Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, [email protected]   Similar Articles: ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS THE SCOPING REVIEW OF CHINESE AND WESTERN MEDICINE TREATMENT OF DIABETIC FOOT IN ASIA ANTIHYPERGLYCEMIC AND ANTI-OXIDANT POTENTIAL OF ETHANOL EXTRACT OF VITEX THYRSIFLORA LEAVES ON DIABETIC RATS EFFECTS OF EMODIN ON BLOOD GLUCOSE AND BODY WEIGHT IN TYPE 1 DIABETIC RATS

scholarly journals Hypoglycemic activity of Phaseolus vulgaris (L.) aqueous extract in type 1 diabetic rats

2019 ◽  
Vol 32 (4) ◽  
pp. 210-218
Author(s):  
Tetiana Halenova ◽  
Natalia Raksha ◽  
Olha Kravchenko ◽  
Tetiana Vovk ◽  
Alona Yurchenko ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Phaseolus Vulgaris ◽  
Aqueous Extract ◽  
Glucose Transporter ◽  
Glucose Utilization ◽  
Muscle Cells ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Skeletal Muscle Cells ◽  
Glut 4

Abstract The aim of the present study was to evaluate the hypoglycemic activity of the aqueous extract from the fruit walls of Phaseolus vulgaris pods and to examine the potential mechanism underlying the improvement of the glycemic level. In the course of the study, diabetes mellitus was induced in rats with a single intraperitoneal injection of streptozotocin (45 mg·kg−1 b.w.). Diabetic and control rats were then orally administered with a single-dose or repeated-dose (28 day) of P. vulgaris extract (200 mg·kg−1). Results show that the extract was found to possess significant hypoglycemic activity, and the study of glucose utilization by isolated rat hemidiaphragm suggests that the aqueous extract may enhance the peripheral utilization of glucose. The subsequent experiments have revealed that the P. vulgaris extract could increase glucose transporter 4 (GLUT-4) content in skeletal muscle cells of control and diabetic rats. Our data also indicate that the P. vulgaris extract did not affect the content of the insulin receptor, but significantly reduced the total tyrosine kinase activity in skeletal muscle cells of both experimental groups of rats. The present results clearly indicated that P. vulgaris extract may be beneficial for reducing hyperglycemia through its potency in regulation of glucose utilization via GLUT-4, but the current mechanism remains to be unidentified.

Effect of Compound Laser Acupuncture-Moxibustion on Blood Glucose, Fasting Insulin and Blood Lipids Levels in Type 2 Diabetic Rats

2019 ◽  
Vol 26 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Yuan Li ◽  
Zhi-yi Qian ◽  
Ke Cheng ◽  
Ling Zhao ◽  
Xue-yong Shen ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Lipids ◽  
Diabetic Rats ◽  
Laser Acupuncture ◽  
Fasting Insulin ◽  
Type 2 Diabetic

Hypoglycemic activity of 6-bromoembelin and vilangin in high-fat diet fed-streptozotocin-induced type 2 diabetic rats and molecular docking studies

Life Sciences ◽  
2016 ◽  
Vol 153 ◽  
pp. 100-117 ◽  
Author(s):  
Antony Stalin ◽  
Santiagu Stephen Irudayaraj ◽  
Gopalsamy Rajiv Gandhi ◽  
Kedike Balakrishna ◽  
Savarimuthu Ignacimuthu ◽  
...  
Keyword(s):  
Molecular Docking ◽  
High Fat Diet ◽  
Docking Studies ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
High Fat ◽  
Molecular Docking Studies ◽  
Type 2 Diabetic

Anti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption

2017 ◽  
Vol 30 (1) ◽  
Author(s):  
Prawej Ansari ◽  
Nadia Afroz ◽  
Shahnaz Jalil ◽  
Sohel Bin Azad ◽  
Md. Gazi Mustakim ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Plasma Insulin Concentration ◽  
Oral Sucrose ◽  
Type 2 Diabetic

AbstractBackground:(commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, ofMethods:This research begins with fasting blood glucose and oral glucose tolerance test (OGTT) to evaluate the primary anti-hyperglycemic effect in chemically induced type 2 diabetic rats. Furthermore, the plasma insulin concentration and serum glucose level were studied, which include measuring the sucrose content in six different segments of the gastrointestinal (GI) tract of the rats following oral sucrose feeding. An in situ, perfused, intestinal model in rats and glucose-fiber binding assay were conducted to find the effects ofResults:Treatment of extracts suppressed blood glucose elevation after oral sucrose (2.5 g/kg) administration and significantly (p<0.05) improved oral glucose tolerance in type 2 diabetic rats.Conclusions:The findings demonstrate that anti-hyperglycemic activity of

scholarly journals The effects of heat treatment on AMPK activation in skeletal muscle in type 2 diabetic rats

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Takamasa Tsuzuki ◽  
Hiroyuki Kobayashi ◽  
Hisashi Naito ◽  
Shizuo Katamoto
Keyword(s):  
Heat Treatment ◽  
Skeletal Muscle ◽  
Diabetic Rats ◽  
Ampk Activation ◽  
Type 2 Diabetic

Effects of Kepok Banana Flour on Glucose Level and Physical Performance in Type 2 Diabetic Rats

2021 ◽  
Vol 1162 ◽  
pp. 137-143
Author(s):  
Muizza Nur Afifa ◽  
Brian Wasita ◽  
Adi Magna Patriadi Nuhriawangsa
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Feed Intake ◽  
Resistant Starch ◽  
Diabetic Rats ◽  
Standard Diet ◽  
Banana Flour ◽  
Type 2 Diabetic

Diabetes mellitus prevalence has rapidly increased globally. Food contains high resistant starch (RS) may be used as a functional food to prevent and control diabetes mellitus. Resistant starch is high in raw bananas and its products such as flour. The study aimed to evaluate effects of Kepok banana flour on blood glucose and physical performance, especially body weight and feed intake in type 2 diabetic rats induced by nicotinamide (NA) and streptozotocin (STZ). Eight-week-old male Wistar rats weighed 150-200 g were randomly divided into nondiabetic and diabetic groups. Nondiabetic group (n=7 rats) was normal control (NC) and fed with standard diet AIN-93M (American Institute of Nutrition Rodent Diets 1993 for adult maintenance), while diabetic groups (n=7 rats each group) consisted of diabetic control (DC) which fed with standard diet and 3 diabetic treatment groups (T1-T3) which fed with AIN-93M containing kepok banana flour with 4%, 8% and 12% of RS respectively for 14 days. After 14 days, mean fasting blood glucose in group T1, T2 and T3 have lower blood glucose than DC significantly (p<0.05) with the highest decrease of blood glucose was on group T3. Mean of body weight in group T1, T2, T3, and NC gained significantly compared to DC group (p<0.05). Feed intake in group T1, T2, T3, and NC were less than DC significantly (p<0.05). Administration of kepok banana flour with 4%, 8% and 12% of RS is able to decrease glucose level, to restore body weight loss and to reduce feed intake in STZ-NA induced type 2 diabetic rats. Kepok banana flour can be proposed as an alternative diet in the management of type 2 diabetes.

scholarly journals Duodenal–Jejunal Bypass Surgery Does Not Increase Skeletal Muscle Insulin Signal Transduction or Glucose Disposal in Goto–Kakizaki Type 2 Diabetic Rats

2010 ◽  
Vol 21 (2) ◽  
pp. 231-237 ◽  
Author(s):  
Timothy P. Gavin ◽  
Ruben C. Sloan ◽  
Eric Z. Lukosius ◽  
Melissa A. Reed ◽  
John R. Pender ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Signal Transduction ◽  
Bypass Surgery ◽  
Diabetic Rats ◽  
Glucose Disposal ◽  
Insulin Signal Transduction ◽  
Insulin Signal ◽  
Jejunal Bypass ◽  
Type 2 Diabetic
Sign in / Sign up

Export Citation Format

Share Document