A Surface-Modified Dendrimer Set for Potential Application as Drug Delivery Vehicles: Synthesis, In Vitro Toxicity, and Intracellular Localization

2004 ◽  
Vol 10 (5) ◽  
pp. 1167-1192 ◽  
Author(s):  
Sabine Fuchs ◽  
Timo Kapp ◽  
Henning Otto ◽  
Torsten Schöneberg ◽  
Peter Franke ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Intracellular Localization ◽  
In Vitro Toxicity ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Surface Modified

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

Nanocargos: A Burgeoning Quest in Cancer Management

2020 ◽  
Vol 10 (2) ◽  
pp. 149-163
Author(s):  
Atul Jain ◽  
Teenu Sharma ◽  
Sumant Saini ◽  
Om Prakash Katare ◽  
Vandana. Soni ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Imaging Techniques ◽  
Intestinal Barrier ◽  
Oral Route ◽  
In Vitro Models ◽  
In Vitro Toxicity ◽  
Cancer Management ◽  
Surface Modified

Cancer, a complex series of diseased conditions, contributes to a significant health problem and is a leading cause of mortalities across the world. Lately, with the advent of improved diagnostics and imaging techniques, and newer advanced oral chemotherapeutics; millions of cancer affected people can lengthen their life span. Despite all the challenges associated with an active chemotherapeutic molecule like microenvironment and the intestinal barrier of the gastrointestinal tract (GIT) etc., the oral delivery remains the most acceptable route of drug administration. In this regard, nanotechnology has played a significant role in the counteracting the challenges encountered with newly developed molecules and aiding in improving their bioavailability and targetability to the tumour site, while administering through the oral route. Several literature instances document the usage of nanostructured drug delivery systems such as lipid-based, polymerbased or metallic nanomaterials to improve the efficacy of chemotherapy. Besides, sitespecific targeted surface-modified drug delivery system designed to deliver the active molecule has opened up to the newer avenues of nanotechnology. However, the issue of potential toxicity allied with nanotechnology cannot be compromised and thus, needs specific ethical regulations and guidelines. The various in vitro models have been developed to evaluate the in vitro toxicity profile which can be further correlated with the invivo model. Thus, this review provides a summarized account of the various aspects related to the role of nanotechnology in cancer therapy and various related issues thereof; that must be triumphed over to apprehend its full promise.

scholarly journals Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2872
Author(s):  
Alberto Concellón ◽  
María San Anselmo ◽  
Silvia Hernández-Ainsa ◽  
Pilar Romero ◽  
Mercedes Marcos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Materials Science ◽  
Nile Red ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Spherical Micelles ◽  
Assembly Behavior ◽  
Hexagonal Columnar

The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.

Bioactive Molecules Delivered by Ceramic Nanoparticles Coated with a Film of Polyhydroxyl Oligomers

1995 ◽  
Vol 394 ◽  
Author(s):  
Nir Kossovsky
Keyword(s):  
Drug Delivery ◽  
Surface Adsorption ◽  
Bioactive Molecules ◽  
Aqueous Environment ◽  
Antigen Delivery ◽  
Drug Delivery Vehicles ◽  
Ceramic Nanoparticles ◽  
Delivery Vehicles ◽  
Carbon Ceramic

AbstractThe structural denaturation of polypeptides and other macromolecular pharmaceuticals upon surface adsorption from an aqueous environment is almost inevitable. Molecular denaturation, coupled with a net increase in entropy, accounts for the net negative ΔG and frequent irreversible nature of surface adsorption. The consequence of this interaction is that surface immobilized drugs lose their dynamic freedom and thus, all too often, their biological activity.This phenomenon has complicated the development of drug delivery vehicles. In this communication, a drug delivery system based on a novel surface modification process to help reverse the constraining activity of surfaces is described. Beginning with preformed carbon ceramic nanoparticles and self-assembled calcium-phosphate dihydrate particles (colloidal precipitation) to which glassy carbohydrates are then allowed to adsorb as a nanometer thick surface coating, a molecular carrier is formed. The carbohydrate coating functions as a dehydroprotectant and stabilizes subsequently non-covalently bound immobilized members of biochemically reactive surface members such as pharmaceuticals.Many of the physical properties of this enabling system have been characterized in vitro and in animal models. Antigen delivery, drug delivery, and enzyme stabilization experiments are described.

Peptide- and Aptamer-Functionalized Nanovectors for Targeted Delivery of Therapeutics

2009 ◽  
Vol 131 (7) ◽  
Author(s):  
Todd O. Pangburn ◽  
Matthew A. Petersen ◽  
Brett Waybrant ◽  
Maroof M. Adil ◽  
Efrosini Kokkoli
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Peptide Ligands ◽  
Drug Delivery Vehicles ◽  
Delivery Vector ◽  
Current State ◽  
Dna Strands ◽  
Delivery Vehicles

Targeted delivery of therapeutics is an area of vigorous research, and peptide- and aptamer-functionalized nanovectors are a promising class of targeted delivery vehicles. Both peptide- and aptamer-targeting ligands can be readily designed to bind a target selectively with high affinity, and more importantly are molecules accessible by chemical synthesis and relatively compact compared with antibodies and full proteins. The multitude of peptide ligands that have been used for targeted delivery are covered in this review, with discussion of binding selectivity and targeting performance for these peptide sequences where possible. Aptamers are RNA or DNA strands evolutionarily engineered to specifically bind a chosen target. Although use of aptamers in targeted delivery is a relatively new avenue of research, the current state of the field is covered and promises of future advances in this area are highlighted. Liposomes, the classic drug delivery vector, and polymeric nanovectors functionalized with peptide or aptamer binding ligands will be discussed in this review, with the exclusion of other drug delivery vehicles. Targeted delivery of therapeutics, from DNA to classic small molecule drugs to protein therapeutics, by these targeted nanovectors is reviewed with coverage of both in vitro and in vivo deliveries. This is an exciting and dynamic area of research and this review seeks to discuss its broad scope.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

Sign in / Sign up

Export Citation Format

Share Document