scholarly journals Impact of environmental factors in predicting daily severity scores of atopic dermatitis

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Guillem Hurault ◽  
Valentin Delorieux ◽  
Young‐Min Kim ◽  
Kangmo Ahn ◽  
Hywel C. Williams ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Severity Scores

scholarly journals Impact of environmental factors in predicting daily severity scores of atopic dermatitis

2020 ◽  
Author(s):  
Guillem Hurault ◽  
Valentin Delorieux ◽  
Young-Min Kim ◽  
Kangmo Ahn ◽  
Hywel C. Williams ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Air Pollutants ◽  
Panel Study ◽  
Predictive Performance ◽  
Statistical Machine Learning ◽  
Short Term ◽  
Mixed Effect ◽  
Severity Scores ◽  
Term Basis

ABSTRACTBackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease that affects 20% of children worldwide. Although environmental factors including weather and air pollutants have been shown to be associated with AD symptoms, the time-dependent nature of such a relationship has not been adequately investigated.ObjectiveThis paper aims to assess the short-term impact of weather and air pollutants on AD severity scores.MethodsUsing longitudinal data from a published panel study of 177 paediatric patients followed up for 17 months, we developed statistical machine learning models to predict daily AD severity scores for individual study participants. Exposures consisted of daily meteorological variables and concentrations of air pollutants and outcomes were daily recordings of scores for six AD signs. We developed a mixed effect autoregressive ordinal logistic regression model, validated it in a forward-chaining setting, and evaluated the effects of the environmental factors on the predictive performance.ResultsOur model outperformed benchmark models for daily prediction of the AD severity scores. The predictive performance of AD severity scores was not improved by the addition of measured environmental factors. Any potential short-term influence of environmental exposures on AD severity scores was outweighed by the underlying persistence of preceding scores.ConclusionsOur data does not offer enough evidence to support a claim that AD symptoms are associated with weather or air pollutants on a short-term basis. Inferences about the magnitude of the effect of environmental factors require consideration of the time-dependence of the AD severity scores.

Environmental Factors and Atopic Dermatitis

2002 ◽  
Vol 14 (4) ◽  
pp. 165-169
Author(s):  
Kristian Thestrup-Pedersen
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors

scholarly journals The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

2021 ◽  
Vol 22 (13) ◽  
pp. 7227
Author(s):  
Lai-San Wong ◽  
Yu-Ta Yen ◽  
Chih-Hung Lee
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Immune Responses ◽  
Immune Cells ◽  
Inflammatory Disease ◽  
Targeted Therapies ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Inflammatory Molecules

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.

Association of Atopic Dermatitis With Indoor Environmental Factors

Epidemiology ◽  
2011 ◽  
Vol 22 ◽  
pp. S169
Author(s):  
Sang-Woon Lee ◽  
Kang-Mo Ahn ◽  
Kyo-Boong Kim ◽  
Min-Young Kim ◽  
Sang-Il Lee
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors

scholarly journals Using family atopy scores to identify the risk of atopic dermatitis in infants

2014 ◽  
Vol 54 (6) ◽  
pp. 330
Author(s):  
Melisa Anggraeni ◽  
Ketut Dewi Kumara Wati ◽  
Ketut Tangking
Keyword(s):  
Atopic Dermatitis ◽  
Cohort Study ◽  
Pregnant Woman ◽  
Environmental Factors ◽  
Antenatal Care ◽  
Early Life ◽  
Early Interventions ◽  
Chi Square

Background Atopic dermatitis is the first manifestation ofallergic disease in early life. Early interventions may prevent thedevelopment of allergy disease. Allergy trace cards have beenused to identify the level of allergic risk, based on family atopyscores. Because environmental factors may also influence thedevelopment of atopic dermatitis, the usefulness of the allergytrace card needs to be reevaluated.Objective To compare the incidence of atopic dermatitis ininfants aged 0-4 months with total family atopy scores of > 0 tothose with scores of 0.Methods We conducted this cohort study from June 1, 2012 toDecember 31, 2012 at Sanglah Hospital, Denpasar. Family atopyscore was tabulated from all pregnant woman in the ObstetricOutpatient Clinic and the Maternity Room. Subjects were dividedinto two groups based on their total family atopy score: those withscores > 0 and those with scores of 0. The appearance of atopicdermatitis symptoms in the infants were evaluated until theyreached 4 months of age. The incidence of atopic dermatitis intwo groups was compared using Chi-square test.Results The incidence of atopic dermatitis in this study was 10.9%.The group with total family atopy scores of 0 had a significantlyhigher incidence of atopic dermatitis than the group with scores> 0 (adjusted RR 22.5; 95%CI 8.8 to 57.0; P = 0.001).Conclusion The incidence of atopic dermatitis is higher ininfants with total family atopy score > 0 and this group has a 22.5times higher risk of atopic dermatitis compared to infants withtotal family atopy score of 0. Allergy trace cards are relevant indifferentiating the risk of atopy with regards to development ofatopic dermatitis. We suggest that family atopy scores be evaluatedduring antenatal care in order to limit the development of atopicdermatitis in infants.

scholarly journals Genetic predisposition and environmental factors associated with the development of atopic dermatitis in infancy: a prospective birth cohort study

2020 ◽  
Vol 179 (9) ◽  
pp. 1367-1377
Author(s):  
Caroline Gallay ◽  
Patrick Meylan ◽  
Sophie Mermoud ◽  
Alexandre Johannsen ◽  
Caroline Lang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Cohort Study ◽  
Environmental Factors ◽  
Birth Cohort ◽  
Genetic Predisposition ◽  
Birth Cohort Study ◽  
Factors Associated ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

Early Environmental Factors for Atopic Dermatitis in Children: Pilot Study of Taiwan Birth Cohort Study (TBCS)

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S230-S231
Author(s):  
H J. Wen ◽  
Y C. Lin ◽  
Y L. Lee ◽  
S J. Lin ◽  
Y L. Chiang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Cohort Study ◽  
Pilot Study ◽  
Environmental Factors ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Taiwan Birth Cohort Study

Gene expression in canine atopic dermatitis and correlation with clinical severity scores

2009 ◽  
Vol 55 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Shona H. Wood ◽  
Dylan N. Clements ◽  
William E. Ollier ◽  
Tim Nuttall ◽  
Neil A. McEwan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atopic Dermatitis ◽  
Clinical Severity ◽  
Canine Atopic Dermatitis ◽  
Severity Scores

scholarly journals Atopic Dermatitis: From Etiology and History to Treatment

2021 ◽  
Vol 48 (3) ◽  
pp. 68-76
Author(s):  
L. Dourmishev ◽  
N. Mironova
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Immunoglobulin E ◽  
Clinical Course ◽  
Inflammatory Skin Disease ◽  
Comprehensive Overview ◽  
Common Skin ◽  
Morphological Variants ◽  
Genetic And Environmental Factors ◽  
Developed World

Abstract Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease in patients with atopy. Atopy itself, is defined as a predisposition to develop immune response with overproduction of immunoglobulin E to low doses of allergens. AD is one of the most common skin disorders in the developed world, affecting up to 20% of children and about 3% of adults. The pathogenesis of the disease is complex, with both genetic and environmental factors playing a significant role in it. Clinically, hallmarks of atopic dermatitis include dry, itchy skin and various cutaneous efflorescence, compatible to dermatitis or eczema. Atopic dermatitis subdivides into three morphological variants manifesting during infancy, childhood and adulthood. Various environmental factors and associated diseases may have serious influence on the clinical course or may trigger disease relapses. The aim of this review article is to serve as a comprehensive overview of the etiology, pathogenesis, clinical course and diagnosis, as well as potential challenges facing the successful treatment of atopic dermatitis.

Sign in / Sign up

Export Citation Format

Share Document