Integration of Self‐Luminescence and Oxygen Self‐Supply: A Potential Photodynamic Therapy Strategy for Deep Tumor Treatment

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

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A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

Chemical Communications ◽

10.1039/d1cc00544h ◽

2021 ◽

Vol 57 (34) ◽

pp. 4134-4137

Author(s):

Rongrong Zheng‡ ◽

Xiayun Chen‡ ◽

Linping Zhao ◽

Ni Yang ◽

Runtian Guan ◽

...

Keyword(s):

Photodynamic Therapy ◽

Mitochondrial Respiration ◽

Tumor Treatment ◽

Hypoxic Tumor

A porphysome-based photodynamic O2 economizer is developed to inhibit mitochondrial respiration for enhanced photodynamic therapy against hypoxic tumors.

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Tailoring photosensitive ROS for advanced photodynamic therapy

Experimental & Molecular Medicine ◽

10.1038/s12276-021-00599-7 ◽

2021 ◽

Author(s):

Duc Loc Sai ◽

Jieun Lee ◽

Duc Long Nguyen ◽

Young-Pil Kim

Keyword(s):

Photodynamic Therapy ◽

Reactive Oxygen Species Generation ◽

Cost Effective ◽

Molecular Medicine ◽

Oxygen Species ◽

Significant Progress ◽

Tumor Treatment ◽

Innovative Strategies ◽

Tumor Microenvironments ◽

Future Challenges

AbstractPhotodynamic therapy (PDT) has been considered a noninvasive and cost-effective modality for tumor treatment. However, the complexity of tumor microenvironments poses challenges to the implementation of traditional PDT. Here, we review recent advances in PDT to resolve the current problems. Major breakthroughs in PDTs are enabling significant progress in molecular medicine and are interconnected with innovative strategies based on smart bio/nanomaterials or therapeutic insights. We focus on newly developed PDT strategies designed by tailoring photosensitive reactive oxygen species generation, which include the use of proteinaceous photosensitizers, self-illumination, or oxygen-independent approaches. While these updated PDT platforms are expected to enable major advances in cancer treatment, addressing future challenges related to biosafety and target specificity is discussed throughout as a necessary goal to expand the usefulness of PDT.

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Photodynamic Therapy for Advanced Rectal Cancer: A Case Report

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v4i6.1613 ◽

2020 ◽

Vol 4 (6) ◽

Author(s):

Lemei Chen ◽

Yanping Liu ◽

Ping Xie ◽

Huizhen Fan

Keyword(s):

Colorectal Cancer ◽

Rectal Cancer ◽

Photodynamic Therapy ◽

Palliative Treatment ◽

Treatment Process ◽

Advanced Colorectal Cancer ◽

Advanced Rectal Cancer ◽

Tumor Treatment ◽

Potential Value ◽

Case Data

Objective: To investigate the potential value of PDT(photodynamic therapy) in the treatment of rectal cancer by reviewing the diagnosis and treatment process of a patient with advanced rectal cancer who lost the opportunity of surgery. Methods: Select the case data of a patient receiving photodynamic therapy in our hospital, and analyze the photodynamic mechanism, safety and efficiency, and discuss the efficacy of photodynamic therapy. Results: After the patient received photodynamic therapy, re-examination of the endoscopy showed that the intestinal cavity was smoother than before, the bowel was difficult, and the symptoms of blood in the stool improved. Conclusion: Photodynamic therapy can be used as a radical or palliative treatment for clinical tumor treatment. Because of its advantages of minimally invasive, tissue-specific, repetitive and synergistic radiotherapy and chemotherapy, it plays an important role in early or middle-advanced colorectal cancer and is worthy of clinical promotion.

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Acute phase response induced following tumor treatment by photodynamic therapy: relevance for the therapy outcome

10.1117/12.640302 ◽

2006 ◽

Cited By ~ 2

Author(s):

Mladen Korbelik ◽

Soroush Merchant ◽

Brandon Stott ◽

Ivana Cecic ◽

Peter Payne ◽

...

Keyword(s):

Photodynamic Therapy ◽

Acute Phase ◽

Acute Phase Response ◽

Phase Response ◽

Therapy Outcome ◽

Tumor Treatment

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Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Nanomaterials ◽

10.3390/nano10102058 ◽

2020 ◽

Vol 10 (10) ◽

pp. 2058

Author(s):

Liang Hong ◽

Artem M. Pliss ◽

Ye Zhan ◽

Wenhan Zheng ◽

Jun Xia ◽

...

Keyword(s):

Photodynamic Therapy ◽

Single Cells ◽

Oxygen Carrier ◽

Chlorin E6 ◽

Tumor Treatment ◽

Selective Treatment ◽

Deep Tissue ◽

Sonodynamic Therapy ◽

Tumor Environment ◽

Hypoxic Tumor

Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

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Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

International Journal of Molecular Sciences ◽

10.3390/ijms20051148 ◽

2019 ◽

Vol 20 (5) ◽

pp. 1148 ◽

Cited By ~ 1

Author(s):

Chun-Chen Yang ◽

Wei-Yun Wang ◽

Feng-Huei Lin ◽

Chun-Han Hou

Keyword(s):

Reactive Oxygen Species ◽

Photodynamic Therapy ◽

Tumor Growth ◽

Light Source ◽

Reactive Oxygen ◽

Blood Analysis ◽

Oxygen Species ◽

Tumor Treatment ◽

X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

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