Longitudinal evaluation of multiple biomarkers for the detection of testosterone gel administration in women with normal menstrual cycle

2021 ◽  
Author(s):  
Olivier Salamin ◽  
Raul Nicoli ◽  
Tobias Langer ◽  
Julien Boccard ◽  
Carine Schweizer Grundisch ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Longitudinal Evaluation ◽  
Testosterone Gel ◽  
Normal Menstrual Cycle ◽  
Multiple Biomarkers

SOME OBSERVATIONS ON PREGNANEDIOL EXCRETION DURING THE NORMAL MENSTRUAL CYCLE

1957 ◽  
Vol 24 (3_Suppl) ◽  
pp. S207
Author(s):  
A. Klopper
Keyword(s):  
Menstrual Cycle ◽  
Corpus Luteum ◽  
New Method ◽  
Menstrual Bleeding ◽  
Normal Menstrual Cycle ◽  
The Relationship ◽  
New View

Abstract The changes in view on the significance and amount of urinary pregnanediol in the menstrual cycle are reviewed; in particular the effects of the discovery that the adrenals in both sexes normally contribute to the urinary pregnanediol. Pregnanediol excretion during the menstrual cycle was studied by means of a new method of assay (Klopper et al., 1955) and the results applied to present day concepts of the growth and duration of the corpus luteum. The relationship between pregnanediol excretion and ovulation or the onset of menstrual bleeding was studied. A new view is put forward on the influence of age and parity on the production of progesterone by the corpus luteum.

Hormone levels in the normal menstrual cycle

Reproduction ◽  
1971 ◽  
Vol 27 (3) ◽  
pp. 481-484 ◽  
Author(s):  
J Newton ◽  
D Joyce ◽  
B Pearce ◽  
C Revell ◽  
J Tyler
Keyword(s):  
Menstrual Cycle ◽  
Hormone Levels ◽  
Normal Menstrual Cycle

Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen

Reproduction ◽  
2000 ◽  
pp. 19-32 ◽  
Author(s):  
ML Martinez ◽  
JD Harris
Keyword(s):  
Menstrual Cycle ◽  
Recombinant Protein ◽  
Antibody Titre ◽  
Zona Pellucida ◽  
Protein A ◽  
Papio Cynocephalus ◽  
Cynomolgus Monkeys ◽  
Menstrual Cycles ◽  
Normal Menstrual Cycle

Immunization of female mammals with native zona pellucida (ZP) proteins is known to cause infertility. Since each human ZP protein is now available as a purified recombinant protein, is it possible to compare the immunocontraceptive potential of each ZP protein. A breeding study was conducted in cynomolgus monkeys (Macaca fasicularis) after immunization with recombinant human ZP (rhZP) proteins (ZPA, ZPB, ZPC) separately and in combinations. This study demonstrated that immunization with recombinant human ZPB (rhZPB) protein caused cynomolgus monkeys to become infertile for 9-35 months. A second study was conducted in baboons (Papio cynocephalus), which yielded a similar result. The baboons immunized with rhZPB became infertile for 9 to > 20 months. During the time of maximum antibody titre, some animals experienced disruption of the menstrual cycle, but eventually all of the animals resumed normal menstrual cycles. Control animals and animals immunized with other rhZP proteins all became pregnant before any of the rhZPB-treated animals. This is the first study in which a recombinant ZP protein has consistently induced infertility in a primate without permanent disruption of the normal menstrual cycle.

Changes in copper and zinc plasma concentrations during the normal menstrual cycle in women

2009 ◽  
pp. 1-6
Author(s):  
Constantinos Michos ◽  
Vasiliki Kalfakakou ◽  
Spyridon Karkabounas ◽  
Dimitrios Kiortsis ◽  
Aggelos Evangelou
Keyword(s):  
Menstrual Cycle ◽  
Plasma Concentrations ◽  
Copper And Zinc ◽  
Normal Menstrual Cycle

Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?

2002 ◽  
Vol 102 (6) ◽  
pp. 639-644 ◽  
Author(s):  
William H. COOKE ◽  
David A. LUDWIG ◽  
Paul S. HOGG ◽  
Dwain L. ECKBERG ◽  
Victor A. CONVERTINO
Keyword(s):  
Menstrual Cycle ◽  
Young Women ◽  
Regulatory Mechanisms ◽  
Physiological Changes ◽  
Menstrual Cycles ◽  
Time Points ◽  
Normal Menstrual Cycle ◽  
Cardiac Regulation ◽  
Neck Pressure ◽  
Noradrenaline Levels

The menstrual cycle provokes several physiological changes that could influence autonomic regulatory mechanisms. We studied the carotid-cardiac baroreflex in ten healthy young women on four occasions over the course of their menstrual cycles (days 0-8, 9-14, 15-20 and 21-25). We drew blood during each session for analysis of oestrogen, progesterone and noradrenaline (norepinephrine) levels, and assessed carotid-cardiac baroreflex function by analysing R-R interval responses to graded neck pressure sequences. Oestrogen levels followed a classical two-peak (cubic) response, with elevated levels on days 9-14 and 21-25 compared with days 0-8 and 15-20 (P =0.0032), while progesterone levels increased exponentially from days 9-14 to days 21-25 (P = 0.0063). Noradrenaline levels increased from an average of 137pg/ml during the first three measurement periods to 199pg/ml during days 21-25 (P = 0.0456). Carotid-cardiac baroreflex gain and operational point were not statistically different at any of the time points during the menstrual cycle (P⩾0.18). These findings are consistent with the notion that beat-to-beat vagal-cardiac regulation does not change over the course of the normal menstrual cycle.

Vaginal Bleeding

2020 ◽  
Keyword(s):  
Menstrual Cycle ◽  
Vaginal Bleeding ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Common Cause ◽  
Key Points ◽  
Normal Menstrual Cycle

Key Points Abnormal uterine bleeding refers to bleeding that is excessive or occurs outside normal cyclic menstruationAnovulatory uterine bleeding is the most common cause of abnormal uterine bleeding adolescents within 1–2 years of menarche.It is important to exclude pregnancy and infections prior to initiating treatment for anovulatory bleedingGoals of management for abnormal uterine bleeding include return to pattern of normal menstrual cycle and prevention of anemia.

Antithrombin III and Platelets during the Normal Menstrual Cycle and in Women Receiving Oral Contraceptives Low in Oestrogen

1983 ◽  
Vol 15 (3) ◽  
pp. 153-162 ◽  
Author(s):  
Jørgen Jespersen ◽  
Steen Ingeberg ◽  
Elsa Bach
Keyword(s):  
Menstrual Cycle ◽  
Oral Contraceptives ◽  
Antithrombin Iii ◽  
Normal Menstrual Cycle

Two-dimensional gel analysis of human endometrial proteins: cyclic changes in the expression of specific proteins during the normal menstrual cycle

1995 ◽  
Vol 10 (1) ◽  
pp. 13-18 ◽  
Author(s):  
I. Byrjalsen ◽  
P.M. Larsen ◽  
S.J. Fey ◽  
L. Thormann ◽  
B.J. Pedersen ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Two Dimensional ◽  
Normal Menstrual Cycle ◽  
Specific Proteins ◽  
Cyclic Changes

Relaxation Times of Normal Breast Tissues

1994 ◽  
Vol 35 (3) ◽  
pp. 258-261 ◽  
Author(s):  
K. I. Dean ◽  
M.-L. Majurin ◽  
M. Komu
Keyword(s):  
Menstrual Cycle ◽  
Healthy Volunteers ◽  
Relaxation Times ◽  
Normal Breast ◽  
Fatty Tissue ◽  
T2 Relaxation ◽  
Breast Parenchyma ◽  
Low Field ◽  
Normal Menstrual Cycle ◽  
Breast Tissues

The influence of age on the relaxation times of normal breast parenchyma and its surrounding fatty tissue were evaluated, and the variations during a normal menstrual cycle were analyzed using an ultra low field 0.02 T imager. Thirty-nine healthy volunteers aged 21 to 59 years were examined to determine T1 and T2 relaxation times, and 8 of these volunteers were studied once weekly during one menstrual cycle. The only significant trend was an increase in the T2 of breast parenchyma with increasing age. During the menstrual cycle there was a slight but insignificant (p = 0.10) increase in T1 of the breast parenchyma values during the latter half of the menstrual cycle, and a corresponding increase in T2 values between the 2nd and 3rd weeks of the menstrual cycle, which was significant (p = 0.003).

Osmoregulation of thirst and vasopressin during normal menstrual cycle

1988 ◽  
Vol 254 (4) ◽  
pp. R641-R647 ◽  
Author(s):  
T. J. Vokes ◽  
N. M. Weiss ◽  
J. Schreiber ◽  
M. B. Gaskill ◽  
G. L. Robertson
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Plasma Osmolality ◽  
Free Water ◽  
Urine Osmolality ◽  
Free Water Clearance ◽  
Vasopressin Release ◽  
Plasma Vasopressin ◽  
Normal Menstrual Cycle ◽  
Basal Plasma

Changes in osmoregulation during normal menstrual cycle were examined in 15 healthy women. In 10 women, studied repetitively during two consecutive menstrual cycles, basal plasma osmolality, sodium, and urea decreased by 4 mosmol/kg, 2 meq/l, and 0.5 mM, respectively (all P less than 0.02) from the follicular to luteal phase. Plasma vasopressin, protein, hematocrit, mean arterial pressure, and body weight did not change. In five other women, diluting capacity and osmotic control of thirst and vasopressin release were assessed in follicular, ovulatory, and luteal phases. Responses of thirst and/or plasma vasopressin, urine osmolality, osmolal and free water clearance to water loading, and infusion of hypertonic saline were normal and similar in the three phases. However, the plasma osmolality at which plasma vasopressin and urine osmolality were maximally suppressed as well as calculated osmotic thresholds for thirst and vasopressin release were lower by 5 mosmol/kg in the luteal than in the follicular phase. This lowering of osmotic thresholds for thirst and vasopressin release, which occurs in the luteal phase, is qualitatively similar to that observed in pregnancy and should be taken into account when studying water balance and regulation of vasopressin secretion in healthy cycling women.

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