Liver stiffness measurement predicted liver‐related events and all‐cause mortality: A systematic review and nonlinear dose–response meta‐analysis

IntroductionEmerging evidence has shown that COVID-19 infection may result in right ventricular (RV) disturbance and be associated with adverse clinical outcomes. The aim of this meta-analysis is to summarise the incidence, risk factors and the prognostic effect of imaging RV involvement in adult patients with COVID-19.MethodsA systematical search will be performed in PubMed, EMBase, ISI Knowledge via Web of Science and preprint databases (MedRxiv and BioRxiv) (until October 2021) to identify all cohort studies in adult patients with COVID-19. The primary outcome will be the incidence of RV involvement (dysfunction and/or dilation) assessed by echocardiography, CT or MRI. Secondary outcomes will include the risk factors for RV involvement and their association with all-cause mortality during hospitalisation. Additional outcomes will include the RV global or free wall longitudinal strain (RV-GLS or RV-FWLS), tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC) and RV diameter. Univariable or multivariable meta-regression and subgroup analyses will be performed for the study design and patient characteristics (especially acute or chronic pulmonary embolism and pulmonary hypertension). Sensitivity analyses will be used to assess the robustness of our results by removing each included study at one time to obtain and evaluate the remaining overall estimates of RV involvement incidence and related risk factors, association with all-cause mortality, and other RV parameters (RV-GLS or RV-FWLS, TAPSE, S’, FAC and RV diameter). Both linear and cubic spline regression models will be used to explore the dose–response relationship between different categories (>2) of RV involvement and the risk of mortality (OR or HR).Ethics and disseminationThere was no need for ethics approval for the systematic review protocol according to the Institutional Review Board/Independent Ethics Committee of Fuwai Hospital. This meta-analysis will be disseminated through a peer-reviewed journal for publication.PROSPERO registration numberCRD42021231689.

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The relationship between major food sources of fructose and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of cohort studies

Critical Reviews in Food Science and Nutrition ◽

10.1080/10408398.2021.2000361 ◽

2021 ◽

pp. 1-14

Author(s):

Asma Kazemi ◽

Sepideh Soltani ◽

Zeinab Mokhtari ◽

Tauseef Khan ◽

Mahdieh Golzarand ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Cohort Studies ◽

Dose Response ◽

Meta Analysis ◽

Food Sources ◽

Major Food ◽

All Cause Mortality ◽

The Relationship

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Physical Activity and Mortality in Cancer Survivors: A Systematic Review and Meta-Analysis

JNCI Cancer Spectrum ◽

10.1093/jncics/pkz080 ◽

2019 ◽

Vol 4 (1) ◽

Cited By ~ 11

Author(s):

Christine M Friedenreich ◽

Chelsea R Stone ◽

Winson Y Cheung ◽

Sandra C Hayes

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Dose Response ◽

Meta Analysis ◽

Menopausal Status ◽

Optimal Dose ◽

Primary Objective ◽

Survival Outcomes ◽

All Cause Mortality ◽

Pa Domain

Abstract Background Recommendations for improved survival after cancer through physical activity (PA) exist, although the evidence is still emerging. Our primary objective was to conduct a systematic review and meta-analysis of the association between prediagnosis and postdiagnosis PA and survival (cancer-specific, all-cause, and cardiovascular disease mortality) for all cancers and by tumor site. Secondary objectives were to examine the associations within population subgroups, by PA domain, and to determine the optimal dose of PA related to survival. Methods PubMed, EMBASE, and SportsDiscus databases were searched from inception to November 1, 2018. DerSimonian-Laird random-effects models were used to estimate the summary hazard ratios (HRs) and 95% confidence intervals (CI) for primary and secondary analyses and to conduct dose-response analyses. Results Evidence from 136 studies showed improved survival outcomes with highest vs lowest levels of prediagnosis or postdiagnosis total or recreational PA for all-cancers combined (cancer specific mortality: HR = 0.82, 95% CI = 0.79 to 0.86, and HR = 0.63, 95% CI = 0.53 to 0.75, respectively) as well as for 11 specific cancer sites. For breast and colorectal cancers, greater reductions were observed for postdiagnosis PA (HR = 0.58–0.63) compared with prediagnosis PA (HR = 0.80–0.86) for cancer-specific and all-cause mortality. Survival benefits through PA were observed in most subgroups (within sex, body mass index, menopausal status, colorectal subtypes, and PA domain) examined. Inverse dose-response relationships between PA and breast cancer-specific and all-cause mortality were observed, with steep reductions in hazards to 10–15 metabolic equivalent hours per week. Conclusion Higher prediagnosis and postdiagnosis levels of PA were associated with improved survival outcomes for at least 11 cancer types, providing support for global promotion of PA guidelines following cancer.

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Prognostic value of liver stiffness measurement for the liver-related surgical outcomes of patients under hepatic resection: A meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0190512 ◽

2018 ◽

Vol 13 (1) ◽

pp. e0190512 ◽

Cited By ~ 5

Author(s):

Zitong Huang ◽

Jingjing Huang ◽

Tianran Zhou ◽

Hongying Cao ◽

Bo Tan

Keyword(s):

Hepatic Resection ◽

Surgical Outcomes ◽

Prognostic Value ◽

Meta Analysis ◽

Liver Stiffness ◽

Liver Stiffness Measurement ◽

Stiffness Measurement

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Ultra-Processed Food Consumption and Adult Mortality Risk: A Systematic Review and Dose–Response Meta-Analysis of 207,291 Participants

Nutrients ◽

10.3390/nu14010174 ◽

2021 ◽

Vol 14 (1) ◽

pp. 174

Author(s):

Wanich Suksatan ◽

Sajjad Moradi ◽

Fatemeh Naeini ◽

Reza Bagheri ◽

Hamed Mohammadi ◽

...

Keyword(s):

Systematic Review ◽

Dose Response ◽

Mortality Risk ◽

Meta Analysis ◽

Experimental Studies ◽

Adult Mortality ◽

Calorie Intake ◽

Response Analysis ◽

Hazard Ratios ◽

All Cause Mortality

We performed a systematic review and dose–response meta-analysis of observational studies assessing the association between UPF consumption and adult mortality risk. A systematic search was conducted using ISI Web of Science, PubMed/MEDLINE, and Scopus electronic databases from inception to August 2021. Data were extracted from seven cohort studies (totaling 207,291 adults from four countries). Using a random-effects model, hazard ratios (HR) of pooled outcomes were estimated. Our results showed that UPF consumption was related to an enhanced risk of all-cause mortality (HR = 1.21; 95% CI: 1.13, 1.30; I2 = 21.9%; p < 0.001), cardiovascular diseases (CVDs)-cause mortality (HR = 1.50; 95% CI: 1.37, 1.63; I2 = 0.0%; p < 0.001), and heart-cause mortality (HR = 1.66; 95% CI: 1.50, 1.85; I2 = 0.0%; p = 0.022), but not cancer-cause mortality. Furthermore, our findings revealed that each 10% increase in UPF consumption in daily calorie intake was associated with a 15% higher risk of all-cause mortality (OR = 1.15; 95% CI: 1.09, 1.21; I2 = 0.0%; p < 0.001). The dose–response analysis revealed a positive linear association between UPF consumption and all-cause mortality (Pnonlinearity = 0.879, Pdose–response = p < 0.001), CVDs-cause mortality (Pnonlinearity = 0.868, Pdose–response = p < 0.001), and heart-cause mortality (Pnonlinearity = 0.774, Pdose–response = p < 0.001). It seems that higher consumption of UPF is significantly associated with an enhanced risk of adult mortality. Despite this, further experimental studies are necessary to draw a more definite conclusion.

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Dose–response association of dietary sodium intake with all-cause and cardiovascular mortality: a systematic review and meta-analysis of prospective studies

Public Health Nutrition ◽

10.1017/s1368980018002112 ◽

2018 ◽

Vol 22 (2) ◽

pp. 295-306 ◽

Cited By ~ 5

Author(s):

Alireza Milajerdi ◽

Kurosh Djafarian ◽

Sakineh Shab-Bidar

Keyword(s):

Systematic Review ◽

Dose Response ◽

Prospective Studies ◽

Sodium Intake ◽

Meta Analysis ◽

Dietary Sodium ◽

Linear Association ◽

All Cause Mortality ◽

Non Linear ◽

Cvd Mortality

AbstractObjectiveHigh Na intake has been associated with different health problems. However, serious controversies exist over studies investigating associations of Na intake with mortality from all-causes and CVD. The present systematic review and meta-analysis was done to investigate, for the first time, the dose–response association of dietary Na intake with all-cause and CVD mortality among prospective studies.DesignRelevant papers published up to August 2017 were searched in MEDLINE, EMBASE and Google Scholar databases. Prospective cohort studies on the association of dietary Na intake with all-cause or/and CVD mortality were included. Linear and non-linear dose–response associations between Na intake and CVD and all-cause mortality were examined.ResultsOverall, twenty publications met inclusion criteria. A significant non-linear association (P<0·001) was found between Na intake and CVD mortality risk among studies assessing urinary Na excretion, with a relatively steep slope at Na intakes above 2400mg/d. However, the association was not significant in studies using dietary Na intake (P=0·61). Additionally, the non-linear association of Na intake with all-cause mortality was also non-significant. No linear association (effect size; 95 % CI; I2) was seen between 100mg/d increment in Na intake and CVD mortality (1·01; 0·97, 1·05; 98·4 %) or all-cause mortality (1·01; 1·00, 1·02; 89·2 %). Following subgroup analyses, the association between Na intake and CVD mortality was observed only among studies conducted in the USA (0·99; 0·99, 1·00; 20·0 %).ConclusionsThe study showed a direct association between urinary Na excretion and CVD mortality which was more considerable at intakes above 2400mg/d. In contrast, no significant association was found between Na intake and all-cause mortality. Further long-term prospective studies on different populations are required to confirm these findings.

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