scholarly journals Cytoplasmic accumulation of activated leukocyte cell adhesion molecule is a predictor of disease progression and reduced survival in oral cancer patients

2009 ◽  
Vol 124 (9) ◽  
pp. 2098-2105 ◽  
Author(s):  
Meenakshi Sawhney ◽  
Ajay Matta ◽  
Muzafar A. Macha ◽  
Jatinder Kaur ◽  
Siddhartha DattaGupta ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Oral Cancer ◽  
Disease Progression ◽  
Cancer Patients ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Oral Cancer Patients ◽  
Cytoplasmic Accumulation

Activated leukocyte cell adhesion molecule (CD166)—Its prognostic power for colorectal cancer patients

2012 ◽  
Vol 177 (1) ◽  
pp. e15-e20 ◽  
Author(s):  
Michael Tachezy ◽  
Hilke Zander ◽  
Florian Gebauer ◽  
Andreas Marx ◽  
Jussuf T. Kaifi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Adhesion ◽  
Cancer Patients ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Colorectal Cancer Patients ◽  
Prognostic Power

Levels of the circulating cell adhesion molecule E-selectin and disease progression in HIV infection

Infection ◽  
1995 ◽  
Vol 23 (4) ◽  
pp. 207-211 ◽  
Author(s):  
P. P. Sfikakis ◽  
P. Sfikakis ◽  
Vana Tzavara ◽  
N. Sipsas ◽  
Olga Kosmopoulou ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Hiv Infection ◽  
Disease Progression ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule

scholarly journals Circulating Tumor Cell Enumeration with a Combination of Epithelial Cell Adhesion Molecule– and Cell-Surface Vimentin–Based Methods for Monitoring Breast Cancer Therapeutic Response

2015 ◽  
Vol 61 (1) ◽  
pp. 259-266 ◽  
Author(s):  
Arun Satelli ◽  
Zachary Brownlee ◽  
Abhisek Mitra ◽  
Qing H Meng ◽  
Shulin Li
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Epithelial Cell ◽  
Cell Surface ◽  
Cancer Patients ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Therapeutic Response ◽  
Breast Cancer Patients ◽  
Epithelial Cell Adhesion Molecule

Abstract BACKGROUND Detection, isolation, and enumeration of circulating tumor cells (CTCs) from cancer patients has become an important modality in clinical management of patients with breast cancer. Although CellSearch, an epithelial cell adhesion molecule (EpCAM)-based method that is used to isolate epithelial CTCs, has gained prominence, its inability to detect mesenchymal CTCs from breast cancer patients raises concerns regarding its utility in clinical management. METHODS To address this gap in technology, we recently discovered the utility of cell-surface vimentin (CSV) as a marker for detecting mesenchymal CTCs from sarcoma tumors. In the present study, we tested the sensitivity and specificity of detecting CTCs from blood collected at a random time during therapy from each of 58 patients with metastatic breast cancer by use of 84-1 (a monoclonal antibody against CSV to detect epithelial/mesenchymal-transition CTCs) and CellSearch methods. Additionally, we tested the possibility of improving the sensitivity and specificity of detection by use of additional parameters including nuclear EpCAM localization and epithelial mesenchymal ratios. RESULTS CTC counts with CSV were significant (P = 0.0053) in differentiating populations responsive and nonresponsive to treatment compared with CTC counts with CellSearch (P = 0.0564). The specificity of CTC detection was found to be highest when the sum of CTC counts from the 2 methods was above a threshold of 8 CTCs/7.5 mL. CONCLUSIONS The sum of CTC counts from the CellSearch and CSV methods appears to provide new insights for assessment of therapeutic response and thus provides a new approach to personalized medicine in breast cancer patients.

scholarly journals Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Maike Ihnen ◽  
Kerstin Kress ◽  
Jan Felix Kersten ◽  
Ergin Kilic ◽  
Matthias Choschzick ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Adhesion ◽  
Cancer Patients ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Tumor Tissue
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