Role of radiotherapy and chemotherapy in the risk of leukemia after childhood cancer: An international pooled analysis

IntroductionFor ill children as well as for their parents and siblings, childhood cancer poses a major challenge. Little is known about the reintegration into daily life of childhood cancer survivors and their families. The aim of this prospective observational study is to further the understanding of the role of rehabilitation measures in the reintegration process of childhood leukaemia or brain tumour survivors and their family members after the end of cancer treatment.Methods and analysisThis prospective observational study consists of three study arms: a quantitative study in cooperation with three German paediatric oncological study registries (study arm 1), a quantitative study in cooperation with a rehabilitation clinic that offers a family-oriented paediatric oncological rehabilitation programme (study arm 2) and a qualitative study at 12-month follow-up including families from the study arms 1 and 2 (study arm 3). In study arm 1, children, parents and siblings are surveyed after treatment (baseline), 4–6 months after baseline measurement and at 12-month follow-up. In study arm 2, data are collected at the beginning and at the end of the rehabilitation measure and at 12-month follow-up. Families are assessed with standardised questionnaires on quality of life, emotional and behavioural symptoms, depression, anxiety, fear of progression, coping and family functioning. Furthermore, self-developed items on rehabilitation aims and reintegration into daily life are used. Where applicable, users and non-users of rehabilitation measures will be compared regarding the outcome parameters. Longitudinal data will be analysed by means of multivariate analysis strategies. Reference values will be used for comparisons if applicable. Qualitative data will be analysed using thematic analysis.Ethics and disseminationThis study has been approved by the medical ethics committee of the Medical Chamber of Hamburg. Data will be published in peer-reviewed journals and presented at conferences.

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Avascular necrosis of bone in childhood cancer patients: a possible role of genetic susceptibility

Bratislava Medical Journal ◽

10.4149/bll_2015_055 ◽

2015 ◽

Vol 116 (05) ◽

pp. 289-295

Author(s):

L. Geczova ◽

A. Soltysova ◽

J. Gecz ◽

S. Sufliarska ◽

J. Horakova ◽

...

Keyword(s):

Childhood Cancer ◽

Genetic Susceptibility ◽

Cancer Patients ◽

Avascular Necrosis ◽

Avascular Necrosis Of Bone

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Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

European Respiratory Journal ◽

10.1183/13993003.00504-2018 ◽

2018 ◽

Vol 52 (3) ◽

pp. 1800504 ◽

Cited By ~ 15

Author(s):

Zuelma A. Contreras ◽

Zhanghua Chen ◽

Theano Roumeliotaki ◽

Isabella Annesi-Maesano ◽

Nour Baïz ◽

...

Keyword(s):

Allergic Rhinitis ◽

Childhood Asthma ◽

Early Onset ◽

Pooled Analysis ◽

Obesity Risk ◽

Obese Children ◽

The Past ◽

Increased Risk ◽

The Uk

The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3–4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18–2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31–3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08–2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.

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Supplemental Material for Childhood Cancer Physical Symptom Burden and Parent Distress: The Role of Parent Rumination

Clinical Practice in Pediatric Psychology ◽

10.1037/cpp0000403.supp ◽

2021 ◽

Keyword(s):

Childhood Cancer ◽

Symptom Burden ◽

Physical Symptom ◽

Parent Distress

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130P Reappraisal of the role of no. 10 lymphadenectomy for proximal gastric cancer in the era of minimal invasive surgery during total gastrectomy: A pooled analysis of 4 prospective trials

Annals of Oncology ◽

10.1016/j.annonc.2020.10.151 ◽

2020 ◽

Vol 31 ◽

pp. S1293

Author(s):

Q. Zhong ◽

G-J. Lin ◽

F-H. Wang ◽

Q-Y. Chen ◽

C-H. Zheng ◽

...

Keyword(s):

Gastric Cancer ◽

Total Gastrectomy ◽

Invasive Surgery ◽

Minimal Invasive Surgery ◽

Pooled Analysis ◽

Minimal Invasive ◽

Proximal Gastric Cancer ◽

Prospective Trials

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Effect of Exposure to Cats and Dogs on the Risk of Asthma and Allergic Rhinitis: A Systematic Review and Meta-analysis

American Journal of Rhinology and Allergy ◽

10.1177/1945892420932487 ◽

2020 ◽

Vol 34 (5) ◽

pp. 703-714

Author(s):

Xiaoping Gao ◽

Mei Yin ◽

Pei Yang ◽

Xia Li ◽

Lingling Di ◽

...

Keyword(s):

Systematic Review ◽

Allergic Rhinitis ◽

Cohort Studies ◽

Meta Analysis ◽

Pooled Analysis ◽

Protective Role ◽

Case Control ◽

Favorable Effect ◽

Case Control Studies

Background Controversies persist regarding whether exposure to cat or dog increases the risk of asthma and allergic rhinitis. Objective This meta-analysis aimed to assess the associations between exposure to cats or dogs and the development of asthma and allergic rhinitis. Methods A systematic review was performed to identify case-control and cohort studies before May 2019, evaluating the association between exposure to cats and dogs and the risk of asthma and rhinitis. The risk of bias was assessed using the Newcastle–Ottawa Scale. The odds ratios (ORs) and risk ratios (RRs) were pooled for case-control and cohort studies, respectively. Subgroup analyses were performed on prespecified study-level characteristics. Results The meta-analysis of 34 cohort studies showed a protective role of exposure to cats [RR: 0.88, 95% confidence interval (CI): 0.77–0.99] or dogs (RR: 0.85, 95% CI: 0.73–0.97) in the development of asthma. The subgroup analysis of birth cohort (RR: 0.74, 95% CI: 0.56–0.93) and children population (RR: 0.83, 95% CI: 0.70–0.96) also suggested a favorable role of exposure to dogs in the development of asthma. Pooled evidence from 13 case-control studies indicated no significant impact of cats (OR: 1.66, 95% CI: 0.39–2.94) and dogs (OR: 1.22, 95% CI: 0.92–1.52) on the development of asthma. A pooled analysis of five cohort studies showed a favorable effect of exposure to cats (RR: 0.60, 95% CI: 0.33–0.86) or dogs (RR: 0.68, 95% CI 0.44–0.90) on the development of allergic rhinitis. Conclusion The findings indicated a protective effect of exposure to cats and dogs, especially ownership, on the development of asthma and allergic rhinitis.

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Family Members Dealing With Childhood Cancer: A Study on the Role of Family Functioning and Cancer Appraisal

Frontiers in Psychology ◽

10.3389/fpsyg.2019.01405 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 1

Author(s):

Marieke Van Schoors ◽

Annick Lena De Paepe ◽

Koenraad Norga ◽

Veerle Cosyns ◽

Hanne Morren ◽

...

Keyword(s):

Family Functioning ◽

Childhood Cancer ◽

Family Members

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Prognostic role of pre-treatment C-reactive protein/albumin ratio in esophageal cancer: a meta-analysis

BMC Cancer ◽

10.1186/s12885-019-6373-y ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Zhenhua Liu ◽

Hongtai Shi ◽

Longyun Chen

Keyword(s):

Esophageal Cancer ◽

Prognostic Value ◽

Meta Analysis ◽

Pooled Analysis ◽

Cochrane Library ◽

C Reactive Protein ◽

Albumin Ratio ◽

Reactive Protein ◽

Pre Treatment

Abstract Background In recent years, the role of pre-treatment C-reactive protein/albumin ratio (CAR) in prognosis of esophageal cancer (EC) has been investigated by several studies. This meta-analysis aimed to provide a more accurate and objective assessment of the prognostic value of pre-treatment CAR in EC. Methods Studies assessing the role of pre-treatment CAR in prognosis of EC were searched from PubMed, Embase and the Cochrane Library (last update by April 16, 2019). The hazard ratios (HRs) of CAR and the corresponding 95% CIs for overall survival (OS) or cancer-specific survival (CSS) in EC were extracted for pooled analysis. Results A total of eight observational studies including 2255 patients were collected. The pooled analysis showed that high CAR was related to worse OS in EC (pooled HR = 1.81; 95% CI = 1.40–2.35; P < 0.001). Subgroup analyses showed that the negative correlation between the CAR and OS was consistently demonstrated in subgroups stratified by country, pathological type, and cut-off value (P < 0.05). However, there was no relation between CAR and OS in subgroup of patients receiving neoadjuvant chemotherapy at a proportion of 100% (HR = 1.15, 95% CI = 0.56–2.69; P = 0.715). In addition, high CAR was also related to worse CSS in EC (pooled HR = 2.61; 95% CI = 1.67–4.06; P < 0.001). Conclusions High pre-treatment CAR was an adverse prognostic factor for EC patients. More large-sample clinical trials are still needed to verify the prognostic value of pre-treatment CAR in EC.

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