Identification of the effective distribution function for determination of the distributed activation energy models using Bayesian statistics: Application of isothermal thermogravimetric data

In the article, based on the analysis of the requirements for the readiness of weapons and military equipment during combat use and the reliability of their operation in the course of combat operations, it was discovered that one of the reasons that causes a discrepancy between the declared failures and real ones may be the incorrect choice and justification of the time distribution function up to the refusal of military means. As a rule, during the development of these tools, the function of distribution of time to failure is chosen by analogy with similar patterns of weapons and military equipment. In the theory of reliability, special attention is given to choosing the function of time-breaking non-response (failures or failures). Therefore, the article deals with the questions of evaluating the effectiveness of functioning of complex systems and methods of modeling the processes of their functioning, taking into account the laws of the distribution of random variables. The discrepancy between the declared irregularity of the military apparatus and the fact that is actually observed in the troops can be explained by the incorrectly accepted hypothesis about the distribution of time to failure. Therefore, the article analyzes the order of the justification of such a function without taking into account the enemy's fire impact and the proposed variant of determining the function of distribution of the time of work until the refusal of the model of military equipment. The article also cites the reasons for the discrepancy between the claimed missile defense equipment and what is actually observed in the troops. The proposed mathematical model of faultlessness, which at stages of designing and design will allow to set requirements to the model of technology with the help of analytical description. The sequence of calculations of non-failure indexes based on the use of Weibull distribution is substantiated.

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Development of HPLC Method for the Purity Test by Design of Experiments and Determination of Activation Energy of Hydrolytic Degradation Reactions of Sofosbuvir

Current Pharmaceutical Analysis ◽

10.2174/1573412915666190225161007 ◽

2020 ◽

Vol 16 (7) ◽

pp. 976-987

Author(s):

Jakub Petřík ◽

Jakub Heřt ◽

Pavel Řezanka ◽

Filip Vymyslický ◽

Michal Douša

Keyword(s):

Activation Energy ◽

Design Of Experiments ◽

Mobile Phase ◽

Hydrolytic Degradation ◽

Isoconversional Method ◽

Hplc Method ◽

Organic Modifier ◽

Calculation Methods ◽

Degradation Reactions

Background: The present study was focused on the development of HPLC method for purity testing of sofosbuvir by the Design of Experiments and determination of the activation energy of hydrolytic degradation reactions of sofosbuvir using HPLC based on the kinetics of sofosbuvir degradation. Methods: Following four factors for the Design of Experiments were selected, stationary phase, an organic modifier of the mobile phase, column temperature and pH of the mobile phase. These factors were examined in two or three level experimental design using Modde 11.0 (Umetrics) software. The chromatographic parameters like resolution, USP tailing and discrimination factor were calculated and analysed by partial least squares. The chromatography was performed based on Design of Experiments results with the mobile phase containing ammonium phosphate buffer pH 2.5 and methanol as an organic modifier. Separation was achieved using gradient elution on XBridge BEH C8 at 50 °C and a flow rate of 0.8 mL/min. UV detection was performed at 220 nm. The activation energy of hydrolytic degradation reactions of sofosbuvir was evaluated using two different calculation methods. The first method is based on the slope of dependence of natural logarithm of the rate constant on inverted thermodynamic temperature and the second approach is the isoconversional method. Results and Conclusion: Calculated activation energies were 77.9 ± 1.1 kJ/mol for the first method and 79.5 ± 3.2 kJ/mol for the isoconversional method. The results can be considered to be identical, therefore both calculation methods are suitable for the determination of the activation energy of degradation reactions.

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New temperature fluctuation method for direct determination of thermal activation energy of deep levels in semiconductors

Electronics Letters ◽

10.1049/el:19830187 ◽

1983 ◽

Vol 19 (7) ◽

pp. 271 ◽

Cited By ~ 1

Author(s):

V. Kumar ◽

H. Indusekhar

Keyword(s):

Activation Energy ◽

Temperature Fluctuation ◽

Thermal Activation ◽

Direct Determination ◽

Thermal Activation Energy ◽

Deep Levels ◽

Fluctuation Method

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Determination of thermodynamic state variables of liquids from its microscopic structure using an artificial neural network

Soft Matter ◽

10.1039/d0sm02127j ◽

2020 ◽

Author(s):

Ulices Que-Salinas ◽

Pedro Ezequiel Ramirez-Gonzalez ◽

Alexis Torres-Carbajal

Keyword(s):

Neural Network ◽

Machine Learning ◽

Artificial Neural Network ◽

Distribution Function ◽

Microscopic Structure ◽

Machine Learning Method ◽

Learning Method ◽

State Variables ◽

Thermodynamic State

In this work we implement a machine learning method to predict the thermodynamic state of a liquid using only its microscopic structure provided by the radial distribution function (RDF). The...

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Cathodoluminescence of SiO2/Si System

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.156-158.487 ◽

2009 ◽

Vol 156-158 ◽

pp. 487-492 ◽

Cited By ~ 1

Author(s):

M.V. Zamoryanskaya

Keyword(s):

Activation Energy ◽

Electron Beam ◽

Rise Time ◽

Silicon Oxide ◽

Beam Current ◽

Electron Beam Current ◽

Electron Traps ◽

Definition Of ◽

Luminescent Centers

In this paper the new method for determination of luminescent centers concentration are discussed. While the possibility of electron traps determination and definition of its activation energy are suggested. The cathodoluminescent (CL) method was used. The determination of luminescent centers concentration in silicon oxide is based on the measurements of dependences of CL intensity on electron beam current. The presence and energy of activation of electron traps were studied by measurement of rise time and decay of luminescent band during the stationary irradiation of silica by electron beam.

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Determination of the membrane hydraulic permeability of MSCs

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2016-0072 ◽

2016 ◽

Vol 2 (1) ◽

pp. 323-327

Author(s):

Jennifer Contreras Lopez ◽

Lothar Lauterböck ◽

Birgit Glasmacher

Keyword(s):

Activation Energy ◽

Bone Marrow ◽

Cooling Rate ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Hydraulic Permeability ◽

Osmotic Behaviour ◽

Additional Influence ◽

Dimethyl Sulfoxid

AbstractA successful cryopreservation is based on knowledge of the optimal cooling rate. So far, this is often determined by way of complex parameter studies. Alternatively, the identification of cell specific characteristics, such as osmotic behaviour, membrane hydraulic permeability and activation energy could be used to calculate the optimal cooling rate. These parameters should be determined for supra-zero and sub-zero temperatures. In this study cryomicroscopy was used. Mesenchymal stromal cells (MSCs) from bone marrow were analysed. The determined membrane hydraulic permeability for sub-zero temperatures is significantly lower than that for supra-zero temperatures. On the contrary the activation energy is significantly higher in the presence of ice. The addition of a cryoprotective agent (CPA) such as dimethyl sulfoxid (DMSO) shows an additional influence on the characteristics of the membrane of the cell. The optimal cooling rate was determined with these parameters. For cryopreservation without DMSO the optimal cooling rate was found to be 12.82 K/min. If the MSCs were frozen with 5% (v/v) DMSO the optimal cooling rate is 16.25 K/min.

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