The individual‐level surrogate threshold effect in a causal‐inference setting with normally distributed endpoints

e16506 Background: In 2013, the GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research through International Collaboration) evaluated the surrogacy of PFS based on IPD of 4,069 patients from 20 randomized trials of AGC. Treatment effects on PFS and on OS were only moderately correlated, and we could not validate PFS as a surrogate endpoint for OS. More recent trials, with refined inclusion criteria and higher standards for evaluating progression, may allow for a more accurate estimate of the correlation. The 2nd round of the GASTRIC sought to re-evaluate the surrogacy of PFS for OS in AGC. Methods: The GASTRIC database was updated with trials published after 2010 which used RECIST (Response Evaluation Criteria in Solid Tumors). Since the proportional hazards assumption was questionable for PFS, we primarily used mean-time ratio as a treatment effect measure, estimated by using the log-logistic model. Using the meta-analytic approach, correlations between PFS and OS at the individual level (Rindiv), and between treatment effects on PFS and on OS at the trial level (Rtrial), were estimated using Spearman’s rank-correlation and estimation-error-adjusted regression, respectively. Surrogate threshold effect was estimated as well. Results: We analyzed 10,912 patient data (1st round 4,069 patients from 20 trials and 2nd round 6,843 patients from 17 trials). Overall, moderate correlations were found at the individual level (Rindiv = 0.75, 95%CI = 0.75 to 0.76 in Hougaard copula) and at the trial level (Rtrial = 0.77, 95%CI = 0.32 to 1.00), respectively. Surrogate threshold effect was equal to 1.29, i.e., observing 29% increase in mean PFS time would predict a significant increase of the OS time. In the subgroup of patients with measurable disease in the 2nd round dataset (4,866 patients), Rtrial was higher and equal to 0.93 (95%CI = 0.70 to 1.00), with STE equal to 1.21. These results were same for 1st and 2nd line trials. Conclusions: The meta-analysis indicates a strong correlation between treatment effects (expressed as log-mean-ratios) on PFS and OS in patients with measurable disease.

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Differential Effects of Competence and Morality on Self-Esteem at the Individual and the Collective Level

Social Psychology ◽

10.1027/1864-9335/a000410 ◽

2020 ◽

Vol 51 (3) ◽

pp. 183-198

Author(s):

Wiktor Soral ◽

Mirosław Kofta

Keyword(s):

Self Esteem ◽

Differential Effects ◽

Individual Level ◽

The Subject ◽

The Individual

Abstract. The importance of various trait dimensions explaining positive global self-esteem has been the subject of numerous studies. While some have provided support for the importance of agency, others have highlighted the importance of communion. This discrepancy can be explained, if one takes into account that people define and value their self both in individual and in collective terms. Two studies ( N = 367 and N = 263) examined the extent to which competence (an aspect of agency), morality, and sociability (the aspects of communion) promote high self-esteem at the individual and the collective level. In both studies, competence was the strongest predictor of self-esteem at the individual level, whereas morality was the strongest predictor of self-esteem at the collective level.

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Empirical analysis of trait models at the individual level

PsycEXTRA Dataset ◽

10.1037/e633912013-137 ◽

2004 ◽

Author(s):

James W. Grice

Keyword(s):

Empirical Analysis ◽

Individual Level ◽

The Individual

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Metonymy in Dance: Ballet Bunheads Take a Cognitive Turn

Dance Research ◽

10.3366/drs.2019.0251 ◽

2019 ◽

Vol 37 (1) ◽

pp. 18-34

Author(s):

Edward C. Warburton

Keyword(s):

Identity Formation ◽

Cognitive Science ◽

Artistic Development ◽

Individual Level ◽

Figures Of Speech ◽

Self Image ◽

Level I ◽

Dance Educators ◽

The Individual ◽

Metaphor And Metonymy

This essay considers metonymy in dance from the perspective of cognitive science. My goal is to unpack the roles of metaphor and metonymy in dance thought and action: how do they arise, how are they understood, how are they to be explained, and in what ways do they determine a person's doing of dance? The premise of this essay is that language matters at the cultural level and can be determinative at the individual level. I contend that some figures of speech, especially metonymic labels like ‘bunhead’, can not only discourage but dehumanize young dancers, treating them not as subjects who dance but as objects to be danced. The use of metonymy to sort young dancers may undermine the development of healthy self-image, impede strong identity formation, and retard creative-artistic development. The paper concludes with a discussion of the influence of metonymy in dance and implications for dance educators.

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Exploring the effect of weight loss on food reward at the individual level

Obesity Abstracts ◽

10.1530/obabs.01.rfc2.3 ◽

2019 ◽

Cited By ~ 1

Author(s):

Pauline Oustric ◽

Kristine Beaulieu ◽

Nuno Casanova ◽

Francois Husson ◽

Catherine Gibbons ◽

...

Keyword(s):

Weight Loss ◽

Food Reward ◽

Individual Level ◽

The Individual

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Personality change and environmental concerns

10.31234/osf.io/jk94r ◽

2020 ◽

Author(s):

Christopher James Hopwood ◽

Ted Schwaba ◽

Wiebke Bleidorn

Keyword(s):

Personality Traits ◽

Personality Change ◽

Environmental Concerns ◽

Big Five Personality ◽

German Population ◽

Individual Level ◽

Sustainable Behavior ◽

Nationally Representative ◽

The Individual ◽

Over Time

Personal concerns about climate change and the environment are a powerful motivator of sustainable behavior. People’s level of concern varies as a function of a variety of social and individual factors. Using data from 58,748 participants from a nationally representative German sample, we tested preregistered hypotheses about factors that impact concerns about the environment over time. We found that environmental concerns increased modestly from 2009-2017 in the German population. However, individuals in middle adulthood tended to be more concerned and showed more consistent increases in concern over time than younger or older people. Consistent with previous research, Big Five personality traits were correlated with environmental concerns. We present novel evidence that increases in concern were related to increases in the personality traits neuroticism and openness to experience. Indeed, changes in openness explained roughly 50% of the variance in changes in environmental concerns. These findings highlight the importance of understanding the individual level factors associated with changes in environmental concerns over time, towards the promotion of more sustainable behavior at the individual level.

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Reply to Connor and Evers (2020): Critique of the Bias of Crowds Model Simply Restates the Model

10.31234/osf.io/ph7yt ◽

2020 ◽

Author(s):

Keith Payne ◽

Heidi A. Vuletich ◽

Kristjen B. Lundberg

Keyword(s):

Implicit Bias ◽

Group Level ◽

Systemic Racism ◽

Individual Level ◽

The Core ◽

Psychological Science ◽

Implicit Biases ◽

The Individual

The Bias of Crowds model (Payne, Vuletich, & Lundberg, 2017) argues that implicit bias varies across individuals and across contexts. It is unreliable and weakly associated with behavior at the individual level. But when aggregated to measure context-level effects, the scores become stable and predictive of group-level outcomes. We concluded that the statistical benefits of aggregation are so powerful that researchers should reconceptualize implicit bias as a feature of contexts, and ask new questions about how implicit biases relate to systemic racism. Connor and Evers (2020) critiqued the model, but their critique simply restates the core claims of the model. They agreed that implicit bias varies across individuals and across contexts; that it is unreliable and weakly associated with behavior at the individual level; and that aggregating scores to measure context-level effects makes them more stable and predictive of group-level outcomes. Connor and Evers concluded that implicit bias should be considered to really be noisily measured individual construct because the effects of aggregation are merely statistical. We respond to their specific arguments and then discuss what it means to really be a feature of persons versus situations, and multilevel measurement and theory in psychological science more broadly.

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Leadership Enactment for Information System Acceptance: an Explanation from a Sensemaking Perspective

Sri Lankan Journal of Management ◽

10.33939/sljm.24.02.04.2019 ◽

2019 ◽

pp. 78-106

Author(s):

Aruna Dayanatha ◽

J A S K Jayakody

Keyword(s):

Information System ◽

User Involvement ◽

High Rate ◽

Is Success ◽

Managerial Leadership ◽

Individual Level ◽

System Acceptance ◽

The Individual ◽

Leadership Intervention ◽

Is Failure

Information system (IS) projects have been seen to be failing at an alarmingly high rate. The prevailing explanations of IS failure have had only a limited success. Thus, the time may be right to look at the reasons for IS failure through an alternative perspective. This paper proposes that IS success should be explained in terms of managerial leadership intervention, from the sensemaking perspective. Managers are responsible for workplace outcomes; thus, it may be appropriate to explain their role in IS success as well. The sensemaking perspective can explain IS success through holistic user involvement, a concept which critiques of existing explanations have stated to be a requirement for explaining IS failure. This paper proposes a framework combining the theory of enactment and leadership enactment to theorize managerial leadership intervention for “IS success.” The proposed explanation postulates that the managerial leader’s envisioning of the future transaction set influences the liberation of the follower and cast enactment, while liberating followers and cast enactment constitute manager sensegiving. The managerial leader’s sense-giving influences follower sensemaking. Follower sensemaking, under the influence of managerial sensegiving, will lead to followers’ IS acceptance, and that constitutes IS success at the individual level. Further, collective level IS acceptance constitutes IS adaption/success, and this will influence the leader’s sensegiving, for the next round of sensemaking.

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