Supplementation with extract of pumpkin seeds exerts estrogenic effects upon the uterine, serum lipids, mammary glands, and bone density in ovariectomized rats

2019 ◽  
Vol 33 (4) ◽  
pp. 891-900
Author(s):  
Beni Lestari ◽  
Ziana Walidah ◽  
Rohmad Yudi Utomo ◽  
Retno Murwanti ◽  
Edy Meiyanto
Keyword(s):  
Bone Density ◽  
Serum Lipids ◽  
Mammary Glands ◽  
Ovariectomized Rats ◽  
Estrogenic Effects ◽  
Pumpkin Seeds

Estrogenic effects of pomegranate extracts in ovariectomized rats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
W Promprom ◽  
W Lijuan ◽  
P Munglue ◽  
P Kupittayanant ◽  
K Indrapichate ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Estrogenic Effects

scholarly journals Danshen enhanced the estrogenic effects of Qing E formula in ovariectomized rats

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Jian-mei Zhang ◽  
Jin Li ◽  
Er-wei Liu ◽  
Hong Wang ◽  
Guan-wei Fan ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Estrogenic Effects

scholarly journals Protective effect ofGlycyrrhiza glabraroots extract on bone mineral density of ovariectomized rats

BioMedicine ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 8 ◽  
Author(s):  
Dimitrios Galanis ◽  
Konstantinos Soultanis ◽  
Pavlos Lelovas ◽  
Alexandros Zervas ◽  
Panagiotis Papadopoulos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Protective Effect ◽  
Bone Mineral ◽  
Proximal Tibia ◽  
Glycyrrhiza Glabra ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Three Point Bending ◽  
Significant Difference

Objective: The aim of this study was to evaluate the potential effect of the methanolic extract of plantGlycyrrhiza glabraroots on bone mineral density and femoral bone strength of ovariectomized rats.Methods: Thirty 10-month-old Wistar rats were randomly separated into three groups of ten, Control, Ovariectomy and Ovariectomy-plus-Glycyrrhiza in their drinking water. Total and proximal tibial bone mineral density was measured in all groups before ovariectomy (baseline) and after 3 and 6 months post ovariectomy. Three-point-bending of the femurs and uterine weight and histology were examined at the end of the study.Results: No significant difference was noted in bone density percentage change of total tibia from baseline to 3 months between Control and Ovariectomy-plus-Glycyrrhiza groups (+5.31% ± 4.75 and +3.30% ± 6.31 respectively,P = non significant), and of proximal tibia accordingly (+5.58% ± 6.92 and +2.61% ± 13.62,P = non significant) demonstrating a strong osteoprotective effect. There was notable difference in percentage change of total tibia from baseline to 6 months between groups Ovariectomy and Ovariectomy-plus-Glycyrrhiza (−13.03% ± 5.11 and −0.84% ± 7.63 respectively,P < 0.005), and of proximal tibia accordingly (−27.9% ± 3.69 and −0.81% ± 14.85 respectively,P < 0.001), confirming the protective effect ofGlycyrrhiza glabraextract in preserving bone density of the Ovariectomy-plus-Glycyrrhiza group. Three-point-bending did not reveal any statistically significant difference between Ovariectomy and Ovariectomy-plus-Glycyrrhiza groups. Uterine weights of the Ovariectomy-plus-Glycyrrhiza group ranged between the other two groups with no statistically significant difference to each.Conclusions:Glycyrrhiza glabraroot extract notably protected tibial bone mineral density loss in Ovariectomy-plus-Glycyrrhiza rats in comparison with ovariectomized rats, but did not improve biomechanical strength.

scholarly journals OPG and PTH-(1–34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats

Endocrinology ◽  
2001 ◽  
Vol 142 (10) ◽  
pp. 4295-4304 ◽  
Author(s):  
Paul J. Kostenuik ◽  
Casey Capparelli ◽  
Sean Morony ◽  
Stephen Adamu ◽  
Grant Shimamoto ◽  
...  
Keyword(s):  
Bone Density ◽  
Mechanical Strength ◽  
Ovariectomized Rats ◽  
Additive Effects

Lupeol, the major compound of the dichloromethane extract of Millettia macrophylla Benth (Fabaceae), displays estrogenic effects in ovariectomized rats

2019 ◽  
Vol 33 (4) ◽  
pp. 949-957 ◽  
Author(s):  
Stéphane Zingue ◽  
Dieudonnée Mireille Ntsa ◽  
Chantal Beatrice Magne Nde ◽  
Thomas Michel ◽  
Derek Tantoh Ndinteh ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Estrogenic Effects

scholarly journals Estrogenic effects of silymarin in ovariectomized rats 

2001 ◽  
Vol 46 (No. 1) ◽  
pp. 17-23 ◽  
Author(s):  
V. Kummer ◽  
J. Mašková ◽  
J. Čanderle ◽  
Z. Zralý ◽  
J. Neča ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Positive Control ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Minor Role ◽  
Control Groups ◽  
Estrogenic Effects ◽  
Ovx Rats ◽  
A Minor ◽  
Negative Controls

The objective of this study was to test whether silymarin induces changes indicative of estrogenic effects in gonadal organs of ovariectomized (OVX) rats. Silymarin was administered in two experimental groups of OVX rats (n&nbsp;= 7 + 7) for 30 days at the doses of 25 or 50 mg per animal per day. OVX rats (n&nbsp;= 7) receiving 5&nbsp;&micro;g of 17b-estradiol (E2) for the last three days before killing and untreated OVX rats (n&nbsp;= 7) were used as the positive and the negative controls, respectively. Uterine and blood samples were collected immediately after killing. Compared with the negative controls, total and normalized uterine weights were significantly higher in the two experimental groups (P&nbsp;&lt; 0.01 and&nbsp;P&nbsp;&lt;&nbsp;0.05, respectively). Uterotrophic effects of silymarin were also evident from increased heights of the luminal epithelium (P&nbsp;&lt; 0.01) and the endometrium (P&nbsp;&lt; 0.05). The response was dose-independent within the tested range. The strongest uterine response was observed in the OVX rats treated with E2. A highly significant decrease in mean density of estrogen receptor (ERa) immunostaining in the luminal and the glandular endometrial epithelia (P&nbsp;&lt; 0.01) and a stronger ERa immunostaining in stromal cells were observed in the two experimental and the positive control groups. The activities of alkaline and acid phosphatases were significantly increased in the luminal (P&nbsp;&lt; 0.05) and the glandular (P&nbsp;&lt; 0.01) epithelia only in the rats treated with E2. Both silymarin and E2&nbsp;induced an increase in thyroid hormone concentrations in blood serum. The rises of free T3&nbsp;and T4&nbsp;were significant (P&nbsp;&lt; 0.05) in the group receiving 50 mg of silymarin per day. Hepatic oxidative metabolism of steroids was assumed to be another target of the action of silymarin. The mitochondrial cytochrome&nbsp;P450-dependent testosterone hydroxylase activity and the cytochrome&nbsp;P4501A-dependent 7-ethoxyresorufin O-deethylase activity were significantly increased (P&nbsp;&lt; 0.05) in the group receiving 50&nbsp;mg of silymarin per day and in the E2-treated control group, respectively. However, the modulations of the CYP enzymes played only a minor role in the overall estrogenic effect of silymarin. Histological and functional alterations in the OVX rats treated orally with silymarin for 30 days were consistent with those seen in E2-treated rats and were indicative of estrogenic effects of silymarin.

scholarly journals Estrogenic Effects of the Herbal Formula, Menoprogen, in Ovariectomized Rats

2010 ◽  
Vol 33 (3) ◽  
pp. 455-460 ◽  
Author(s):  
Hong Ma ◽  
Mi Hwa Chung ◽  
Ye Lu ◽  
Tsutomu Nishihara ◽  
Masao Hattori
Keyword(s):  
Ovariectomized Rats ◽  
Herbal Formula ◽  
Estrogenic Effects

Melatonin prevents the estrogenic effects of sub-chronic administration of cadmium on mice mammary glands and uterus

2007 ◽  
Vol 42 (4) ◽  
pp. 403-410 ◽  
Author(s):  
C. Alonso-González ◽  
A. González ◽  
O. Mazarrasa ◽  
A. Güezmes ◽  
S. Sánchez-Mateos ◽  
...  
Keyword(s):  
Chronic Administration ◽  
Mammary Glands ◽  
Estrogenic Effects

scholarly journals The Combination of High Calcium Milk with Citrus maxima Peels Ethanolic Extract Increased Bone Density of Ovariectomized Rats

2017 ◽  
Vol 6 (2) ◽  
pp. 42
Author(s):  
Ragil S. Dianingati ◽  
Annisa Novarina ◽  
Amanita K. Hana ◽  
Laeli Muntafi'ah ◽  
Endang Lukitaningsih
Keyword(s):  
Estrogen Receptor ◽  
Bone Density ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Menopausal Woman ◽  
Good Prospect ◽  
Sprague Dawley ◽  
Docking Score ◽  
High Calcium ◽  
Citrus Maxima

Osteoporosis is a common problem in menopause woman. The main cause is lack of estrogen hormone. Commonly, prevention therapy is by consuming high calcium milk, but it is not effective. Bali orange’s peel (Citrus maxima Merr.) is a waste material but known contains phytoestrogen according to previous study. Considering of this result, fortification of high calcium milk and Bali orange’s peel is expected to be an effective solution for osteoporosis in menopause woman. This research began with extraction of Bali orange’s peel (BPE) using ethanol 70% by maceration method. Ovariectomized Sprague Dawley female rats as the model of post menopausal woman were treated by BPE for 28 days. The doses of BPE was given to rats is 500 and 1000 mg/KgBW combined with high calcium milk. Bone density was determined using digital microradiography, the profile showed the increase of bone density in group that treated with combination of BPE 1000 mg/Kg BW and high calcium milk compare to control and given only milk groups. Docking molecular showed that BPE’s active compound which are hesperidin and naringin have interaction with estrogen receptor α and β. Docking score of naringin with ER α and β are -19,97; -18,99 respectively. Meanwhile the docking score of hesperidin with ER α and β are -19,98; +49,92 respectively. Overall, the result of this research showed that fortification of BPE with high calcium milk has good prospect to develop as effective therapy of osteoporosis.Keywords : Citrus maxima Merr., phytoestrogen, osteoporosis, high calcium milk, estrogen receptor 

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