Recent Advances in Patterning Natural Polymers: From Nanofabrication Techniques to Applications

Small Methods ◽  
2021 ◽  
Vol 5 (3) ◽  
pp. 2001060
Author(s):  
Shuihong Zhu ◽  
Yonghua Tang ◽  
Changxu Lin ◽  
Xiang Yang Liu ◽  
Youhui Lin
Keyword(s):  
Natural Polymers ◽  
Recent Advances

scholarly journals Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

2021 ◽  
Vol 22 (19) ◽  
pp. 10337
Author(s):  
Anna Paradowska-Stolarz ◽  
Mieszko Wieckiewicz ◽  
Artur Owczarek ◽  
Joanna Wezgowiec
Keyword(s):  
Oral Health ◽  
Oral Drug Delivery ◽  
Dental Treatment ◽  
Wide Spectrum ◽  
Periodontal Diseases ◽  
Comparative Characteristic ◽  
Oral Drug ◽  
Natural Polymers ◽  
Natural Origin ◽  
Recent Advances

The success of modern dental treatment is strongly dependent on the materials used both temporarily and permanently. Among all dental materials, polymers are a very important class with a wide spectrum of applications. This review aims to provide a state-of-the-art overview of the recent advances in the field of natural polymers used to maintain or restore oral health. It focuses on the properties of the most common proteins and polysaccharides of natural origin in terms of meeting the specific biological requirements in the increasingly demanding field of modern dentistry. The use of naturally derived polymers in different dental specialties for preventive and therapeutic purposes has been discussed. The major fields of application cover caries and the management of periodontal diseases, the fabrication of membranes and scaffolds for the regeneration of dental structures, the manufacturing of oral appliances and dentures as well as providing systems for oral drug delivery. This paper also includes a comparative characteristic of natural and synthetic dental polymers. Finally, the current review highlights new perspectives, possible future advancements, as well as challenges that may be encountered by researchers in the field of dental applications of polymers of natural origin.

scholarly journals PROCESSAMENTO E APLICAÇÃO DE BIOMATERIAIS POLIMÉRICOS: AVANÇOS RECENTES E PERSPECTIVAS

Química Nova ◽  
2021 ◽  
Author(s):  
Marcela Bernardo ◽  
Rafaella Paschoalin ◽  
Danilo Santos ◽  
Stanley Bilatto ◽  
Cristiane Farinas ◽  
...  
Keyword(s):  
Polymeric Materials ◽  
The Elderly ◽  
Patient Specific ◽  
Natural Polymers ◽  
Polymeric Biomaterials ◽  
Recent Advances ◽  
High Prevalence ◽  
Manufacturing Techniques ◽  
Orthopedic Diseases ◽  
Processing Techniques

PROCESSING AND APPLICATION OF POLYMERIC BIOMATERIALS: RECENT ADVANCES AND PERSPECTIVES. Biomaterials have been intensively investigated due to the increase in the elderly population and high prevalence of several disorders, such as cardiovascular and orthopedic diseases. Polymeric and composite polymeric materials in combination with different processing techniques, such as electrospinning, solution blow spinning, ultrathin film preparation, and 3D printing are promising for obtaining biomaterials with patient-specific applications. Here, we provide a review on recent advances and perspectives for synthetic and natural polymers as well as composites in the design of biomaterials. After introducing basic information about biomaterials, we describe the fundamentals of manufacturing techniques and highlight possible biomedical applications.

Recent Advances in Gelatin-Based Nanomedicine for Targeted Delivery of Anti-Cancer Drugs

2021 ◽  
Vol 27 ◽  
Author(s):  
Faisal Raza ◽  
Liu Siyu ◽  
Hajra Zafar ◽  
Zul Kamal ◽  
Bo Zheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
Natural Polymers ◽  
Gelatin Nanoparticles ◽  
Good Surface ◽  
Recent Advances ◽  
Wide Range ◽  
Anti Cancer ◽  
Cancer Nanomedicine

: Nanoparticles based on natural polymers are utilized for the development of a wide range of drug delivery systems (DDS) in the current era. Gelatin-based nanoparticles, for example, are a remarkable cancer therapy with high efficacy and specificity. This paper reviews the recent advancements in gelatin-based nanomedicine for use in cancer therapeutics. Due to the characteristics features of gelatin, such as biocompatibility, biodegradability, stability, and good surface properties, these nanoparticles provide high therapeutic potency in cancer nanomedicine. The surface of gelatin can be modified in a number of ways using various ligands to explore the platform for the development of a more novel DDS. Various methods are available for the preparation of gelatin nanomedicine discussed in this review. In addition, various cross-linkers to stabilized nanocarriers and stimuli base gelatin nanoparticles are reviewed. Furthermore, recent advances and research in gelatin-based nanomedicine are discussed. Also, some drawbacks and challenges are evaluated. In general, this paper paves the pathway to identify the details about the gelatin-based DDS for cancer therapy.

scholarly journals Recent Advances in the Excipients Used in Modified Release Vaginal Formulations

Materials ◽  
2022 ◽  
Vol 15 (1) ◽  
pp. 327
Author(s):  
Aikaterini Dedeloudi ◽  
Angeliki Siamidi ◽  
Panagoula Pavlou ◽  
Marilena Vlachou
Keyword(s):  
Drug Delivery ◽  
Natural Polymers ◽  
Regulatory Requirements ◽  
Solid Dosage Forms ◽  
Vaginal Drug Delivery ◽  
Solid Dosage ◽  
Recent Advances ◽  
Semi Solid ◽  
Promising Perspective ◽  
Synthetic And Natural Polymers

The formulation of an ideal vaginal drug delivery system (DDS), with the requisite properties, with respect to safety, efficacy, patient compliance, aesthetics, harmonization with the regulatory requirements, and cost, requires a meticulous selection of the active ingredients and the excipients used. Novel excipients defined by diversity and multifunctionality are used in order to ameliorate drug delivery attributes. Synthetic and natural polymers are broadly used in pharmaceutical vaginal formulations (solid, semi-solid dosage forms, implantable devices, and nanomedicines) with a promising perspective in improving stability and compatibility issues when administered topically or systemically. Moreover, the use of biopolymers is aiming towards formulating novel bioactive, biocompatible, and biodegradable DDSs with a controllable drug release rate. Overviewing vaginal microenvironment, which is described by variable and perplexed features, a perceptive choice of excipients is essential. This review summarizes the recent advances on the excipients used in modified vaginal drug delivery formulations, in an attempt to aid the formulation scientist in selecting the optimal excipients for the preparation of vaginal products.

scholarly journals Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 33
Author(s):  
Silvia Voci ◽  
Agnese Gagliardi ◽  
Roberto Molinaro ◽  
Massimo Fresta ◽  
Donato Cosco
Keyword(s):  
Potential Role ◽  
Tumor Therapy ◽  
Chemical Properties ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Recent Advances ◽  
Physico Chemical ◽  
Polar Media ◽  
Anti Cancer ◽  
Cancer Activity

The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

scholarly journals Recent Advances in Scaffolding from Natural-Based Polymers for Volumetric Muscle Injury

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 699
Author(s):  
Tamrin Nuge ◽  
Ziqian Liu ◽  
Xiaoling Liu ◽  
Bee Chin Ang ◽  
Andri Andriyana ◽  
...  
Keyword(s):  
Muscle Injury ◽  
Biologically Active ◽  
Special Focus ◽  
Muscle Loss ◽  
Natural Polymers ◽  
Volumetric Muscle Loss ◽  
Recent Advances ◽  
Wide Range ◽  
Tissue Scaffolding ◽  
And Migration

Volumetric Muscle Loss (VML) is associated with muscle loss function and often untreated and considered part of the natural sequelae of trauma. Various types of biomaterials with different physical and properties have been developed to treat VML. However, much work remains yet to be done before the scaffolds can pass from the bench to the bedside. The present review aims to provide a comprehensive summary of the latest developments in the construction and application of natural polymers-based tissue scaffolding for volumetric muscle injury. Here, the tissue engineering approaches for treating volumetric muscle loss injury are highlighted and recent advances in cell-based therapies using various sources of stem cells are elaborated in detail. An overview of different strategies of tissue scaffolding and their efficacy on skeletal muscle cells regeneration and migration are presented. Furthermore, the present paper discusses a wide range of natural polymers with a special focus on proteins and polysaccharides that are major components of the extracellular matrices. The natural polymers are biologically active and excellently promote cell adhesion and growth. These bio-characteristics justify natural polymers as one of the most attractive options for developing scaffolds for muscle cell regeneration.

Recent Advances in Nasal Drug Delivery Using Natural Polymers

2012 ◽  
Vol 7 (3) ◽  
pp. 170-178 ◽  
Author(s):  
Nirmala Prajapati ◽  
Pranati Srivastava ◽  
Shilpi Bhargava
Keyword(s):  
Drug Delivery ◽  
Natural Polymers ◽  
Nasal Drug Delivery ◽  
Recent Advances

The potential of polymers from natural sources as components of the blends for biomedical and cosmetic applications

2015 ◽  
Vol 87 (11-12) ◽  
pp. 1075-1084 ◽  
Author(s):  
Alina Sionkowska
Keyword(s):  
Silk Fibroin ◽  
Good Alternative ◽  
Synthetic Polymers ◽  
Natural Polymers ◽  
Natural Sources ◽  
Biobased Materials ◽  
Short Overview ◽  
Recent Advances

AbstractA short overview of recent advances in studies of the interactions between natural polymers and application of polymers from natural sources as components of the blends for biomedical and cosmetic applications is presented. This work is focused on the blends of collagen, chitosan, silk fibroin and keratin. These bioinspired and biobased materials can be good alternative for materials based on synthetic polymers. The case study of the blends made of collagen and keratin hydrolysate is presented.

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