Materials Used in Microfluidic Devices

2015 ◽  
pp. 1723-1726 ◽  
Author(s):  
Xin Liu ◽  
Bingcheng Lin
Keyword(s):  
Microfluidic Devices ◽  
Materials Used

scholarly journals Fabrication and Bonding of Refractive Index Matched Microfluidics for Precise Measurements of Cell Mass

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 496
Author(s):  
Edward R. Polanco ◽  
Justin Griffin ◽  
Thomas A. Zangle
Keyword(s):  
Image Processing ◽  
Refractive Index ◽  
Cell Mass ◽  
Microfluidic Devices ◽  
Polymer Materials ◽  
Optical Measurements ◽  
Cell Segmentation ◽  
Uv Curable ◽  
Processing Approach ◽  
Materials Used

The optical properties of polymer materials used for microfluidic device fabrication can impact device performance when used for optical measurements. In particular, conventional polymer materials used for microfluidic devices have a large difference in refractive index relative to aqueous media generally used for biomedical applications. This can create artifacts when used for microscopy-based assays. Fluorination can reduce polymer refractive index, but at the cost of reduced adhesion, creating issues with device bonding. Here, we present a novel fabrication technique for bonding microfluidic devices made of NOA1348, which is a fluorinated, UV-curable polymer with a refractive index similar to that of water, to a glass substrate. This technique is compatible with soft lithography techniques, making this approach readily integrated into existing microfabrication workflows. We also demonstrate that this material is compatible with quantitative phase imaging, which we used to validate the refractive index of the material post-fabrication. Finally, we demonstrate the use of this material with a novel image processing approach to precisely quantify the mass of cells in the microchannel without the use of cell segmentation or tracking. The novel image processing approach combined with this low refractive index material eliminates an important source of error, allowing for high-precision measurements of cell mass with a coefficient of variance of 1%.

scholarly journals Microfluidic Synthesis of Iron Oxide Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2113
Author(s):  
Matthew James ◽  
Richard A Revia ◽  
Zachary Stephen ◽  
Miqin Zhang
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Microfluidic Devices ◽  
Synthesis Process ◽  
Oxide Nanoparticles ◽  
Coprecipitation Synthesis ◽  
High Production ◽  
Materials Used

Research efforts into the production and application of iron oxide nanoparticles (IONPs) in recent decades have shown IONPs to be promising for a range of biomedical applications. Many synthesis techniques have been developed to produce high-quality IONPs that are safe for in vivo environments while also being able to perform useful biological functions. Among them, coprecipitation is the most commonly used method but has several limitations such as polydisperse IONPs, long synthesis times, and batch-to-batch variations. Recent efforts at addressing these limitations have led to the development of microfluidic devices that can make IONPs of much-improved quality. Here, we review recent advances in the development of microfluidic devices for the synthesis of IONPs by coprecipitation. We discuss the main architectures used in microfluidic device design and highlight the most prominent manufacturing methods and materials used to construct these microfluidic devices. Finally, we discuss the benefits that microfluidics can offer to the coprecipitation synthesis process including the ability to better control various synthesis parameters and produce IONPs with high production rates.

scholarly journals Cell adhesion and proliferation on common 3D printing materials used in stereolithography of microfluidic devices

Lab on a Chip ◽  
2020 ◽  
Vol 20 (13) ◽  
pp. 2372-2382 ◽  
Author(s):  
Kati Piironen ◽  
Markus Haapala ◽  
Virpi Talman ◽  
Päivi Järvinen ◽  
Tiina Sikanen
Keyword(s):  
Cell Adhesion ◽  
3D Printing ◽  
Cell Survival ◽  
Microfluidic Devices ◽  
3D Printed ◽  
Materials Used ◽  
Cell Adhesion And Proliferation

This work reveals the material impacts on long-term cell survival and adhesion on 3D printed surfaces manufactured by stereolithography.

Micro Milling for Polymer Materials Used in Prototyping of Microfluidic Chip Application

2012 ◽  
Vol 565 ◽  
pp. 552-557 ◽  
Author(s):  
Aramcharoen Ampara ◽  
Kah Chuan Sean Shaw ◽  
Kui Liu
Keyword(s):  
Aspect Ratio ◽  
Microfluidic Chip ◽  
Microfluidic Devices ◽  
Milling Process ◽  
Polymer Materials ◽  
Micro Milling ◽  
Machined Surface ◽  
Biocompatible Polymer ◽  
Machined Surface Quality ◽  
Materials Used

Micro milling is one of the processes that can be used in microfluidic devices fabrication. It has shown the capability for producing the freeform geometries, cost and time effectively. This paper presents the cutting strategies for micro milling process for an application of microfluidic device. The proposed strategies demonstrated the capability of micro milling process to fabricate microchannel and micropillar array from biocompatible polymer materials with good machined surface quality and high aspect ratio of up to three.

Deformation Replication

1970 ◽  
Vol 28 ◽  
pp. 280-281
Author(s):  
J. Temple Black
Keyword(s):  
Cutting Speed ◽  
Machining Process ◽  
Depth Of Cut ◽  
Rake Face ◽  
Orthogonal Machining ◽  
Aluminum Chips ◽  
Before And After ◽  
Materials Used ◽  
Glass Knife ◽  
Very High

Tool materials used in ultramicrotomy are glass, developed by Latta and Hartmann (1) and diamond, introduced by Fernandez-Moran (2). While diamonds produce more good sections per knife edge than glass, they are expensive; require careful mounting and handling; and are time consuming to clean before and after usage, purchase from vendors (3-6 months waiting time), and regrind. Glass offers an easily accessible, inexpensive material ($0.04 per knife) with very high compressive strength (3) that can be employed in microtomy of metals (4) as well as biological materials. When the orthogonal machining process is being studied, glass offers additional advantages. Sections of metal or plastic can be dried down on the rake face, coated with Au-Pd, and examined directly in the SEM with no additional handling (5). Figure 1 shows aluminum chips microtomed with a 75° glass knife at a cutting speed of 1 mm/sec with a depth of cut of 1000 Å lying on the rake face of the knife.

High Voltage Transmission Microscopy of Surveyor III Camera Shrouds

1971 ◽  
Vol 29 ◽  
pp. 138-139
Author(s):  
W. R. Duff ◽  
L. E. Thomas ◽  
R. M. Fisher ◽  
S. V. Radcliffe
Keyword(s):  
Alloy Sheet ◽  
Transmission Microscopy ◽  
Television Camera ◽  
Window Method ◽  
Transmission Electron ◽  
Microstructural Effects ◽  
Lunar Environment ◽  
Successful Retrieval ◽  
Materials Used ◽  
Abrasive Paper

Successful retrieval of the television camera and other components from the Surveyor III spacecraft by the Apollo 12 astronauts has provided a unique opportunity to study the effects of a known and relatively extensive exposure to the lunar environment. Microstructural effects including those produced by micro-meteorite impact, radiation damage (by both the solar wind and cosmic rays) and solar heating might be expected in the materials used to fabricate the spacecraft. Samples received were in the form of 1 cm2 of painted unpainted aluminum alloy sheet from the top of the camera visor (JPL Code 933) and the sides (935,936) and bottom (934) of the lower camera shroud. They were prepared for transmission electron microscopy by first hand-grinding with abrasive paper to a thickness of 0.006". The edges were lacquered and the sample electropolished in 10% perchloric methanol using the “window” method, to a thickness of ~0.001". Final thinning was accomplished by polishing 3 mm punched disks in an acetic-phosphoric-nitric acid solution.

Structure-property relationships of PE/PP sandwiched films

1987 ◽  
Vol 45 ◽  
pp. 454-455
Author(s):  
J. Petermann ◽  
G. Broza ◽  
U. Rieck ◽  
A. Jaballah ◽  
A. Kawaguchi
Keyword(s):  
Mechanical Tests ◽  
Polymer Materials ◽  
Ionic Crystals ◽  
Structure Property ◽  
Polymer Systems ◽  
Structure Property Relationships ◽  
Oriented Films ◽  
Materials Used ◽  
Polymer Laminates ◽  
Heated Glass

Oriented overgrowth of polymer materials onto ionic crystals is well known and recently it was demonstrated that this epitaxial crystallisation can also occur in polymer/polymer systems, under certain conditions. The morphologies and the resulting physical properties of such systems will be presented, especially the influence of epitaxial interfaces on the adhesion of polymer laminates and the mechanical properties of epitaxially crystallized sandwiched layers.Materials used were polyethylene, PE, Lupolen 6021 DX (HDPE) and 1810 D (LDPE) from BASF AG; polypropylene, PP, (PPN) provided by Höchst AG and polybutene-1, PB-1, Vestolen BT from Chemische Werke Hüls. Thin oriented films were prepared according to the method of Petermann and Gohil, by winding up two different polymer films from two separately heated glass-plates simultaneously with the help of a motor driven cylinder. One double layer was used for TEM investigations, while about 1000 sandwiched layers were taken for mechanical tests.

Sign in / Sign up

Export Citation Format

Share Document