Track Structure, Chromosome Geometry and Chromosome Aberrations

1994 ◽  
pp. 93-113
Author(s):  
David J. Brenner ◽  
John F. Ward ◽  
Rainer K. Sachs
Keyword(s):  
Chromosome Aberrations ◽  
Track Structure

Effect of LET and track structure on the statistical distribution of chromosome aberrations

2007 ◽  
Vol 39 (6) ◽  
pp. 1070-1075 ◽  
Author(s):  
E. Gudowska-Nowak ◽  
R. Lee ◽  
E. Nasonova ◽  
S. Ritter ◽  
M. Scholz
Keyword(s):  
Chromosome Aberrations ◽  
Statistical Distribution ◽  
Track Structure

Bestimmung der DNA-Schädigung in vitro

2010 ◽  
Vol 49 (S 01) ◽  
pp. S64-S68
Author(s):  
E. Dikomey
Keyword(s):  
Dna Damage ◽  
Cell Lines ◽  
Chromosome Aberrations ◽  
Genetic Factors ◽  
Double Strand Breaks ◽  
Strand Breaks ◽  
Cell Inactivation ◽  
Repair Mechanisms ◽  
Break Repair

SummaryIonising irradiation acts primarily via induction of DNA damage, among which doublestrand breaks are the most important lesions. These lesions may lead to lethal chromosome aberrations, which are the main reason for cell inactivation. Double-strand breaks can be repaired by several different mechanisms. The regulation of these mechanisms appears be fairly different for normal and tumour cells. Among different cell lines capacity of doublestrand break repair varies by only few percents and is known to be determined mostly by genetic factors. Knowledge about doublestrand break repair mechanisms and their regulation is important for the optimal application of ionising irradiation in medicine.

scholarly journals Theoretical analysis and experimental research on multi-layer elastic damping track structure

2021 ◽  
Vol 13 (2) ◽  
pp. 168781402199497
Author(s):  
Guanghui Xu ◽  
Shengkai Su ◽  
Anbin Wang ◽  
Ruolin Hu
Keyword(s):  
Finite Element ◽  
Analytical Solution ◽  
Finite Element Simulation ◽  
Reaction Force ◽  
Vibration Reduction ◽  
Vertical Direction ◽  
Propagation Path ◽  
Track Structure ◽  
Test Results ◽  
Element Simulation

The increase of axle load and train speed would cause intense wheelrail interactions, and lead to potential vibration related problems in train operation. For the low-frequency vibration reduction of a track system, a multi-layer track structure was proposed and analyzed theoretically and experimentally. Firstly, the analytical solution was derived theoretically, and followed by a parametric analysis to verify the vibration reduction performance. Then, a finite element simulation is carried out to highlight the influence of the tuned slab damper. Finally, the vibration and noise tests are performed to verify the results of the analytical solution and finite element simulation. As the finite element simulation indicates, after installation of the tuned slab damper, the peak reaction force of the foundation can be reduced by 60%, and the peak value of the vertical vibration acceleration would decrease by 50%. The vibration test results show that the insertion losses for the total vibration levels are 13.3 dB in the vertical direction and 21.7 dB in the transverse direction. The noise test results show that the data of each measurement point is smoother and smaller, and the noise in the generating position and propagation path can be reduced by 1.9 dB–5.5 dB.

scholarly journals Mechanical Performance of a Ballastless Track System for the Railway Bridges of High-Speed Lines: Experimental and Numerical Study under Thermal Loading

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2876
Author(s):  
Yingying Zhang ◽  
Lingyu Zhou ◽  
Akim D. Mahunon ◽  
Guangchao Zhang ◽  
Xiusheng Peng ◽  
...  
Keyword(s):  
High Speed ◽  
Thermal Loading ◽  
Mechanical Performance ◽  
Track Structure ◽  
Box Girder ◽  
High Speed Railway ◽  
Ballastless Track ◽  
Track System ◽  
Girder Bridge ◽  
Track Slab

The mechanical performance of China Railway Track System type II (CRTS II) ballastless track suitable for High-Speed Railway (HSR) bridges is investigated in this project by testing a one-quarter-scaled three-span specimen under thermal loading. Stress analysis was performed both experimentally and numerically, via finite-element modeling in the latter case. The results showed that strains in the track slab, in the cement-emulsified asphalt (CA) mortar and in the track bed, increased nonlinearly with the temperature increase. In the longitudinal direction, the zero-displacement section between the track slab and the track bed was close to the 1/8L section of the beam, while the zero-displacement section between the track slab and the box girder bridge was close to the 3/8L section. The maximum values of the relative vertical displacement between the track bed and the bridge structure occurred in the section at three-quarters of the span. Numerical analysis showed that the lower the temperature, the larger the tensile stresses occurring in the different layers of the track structure, whereas the higher the temperature, the higher the relative displacement between the track system and the box girder bridge. Consequently, quantifying the stresses in the various components of the track structure resulting from sudden temperature drops and evaluating the relative displacements between the rails and the track bed resulting from high-temperature are helpful in the design of ballastless track structures for high-speed railway lines.

scholarly journals DNA-Replikationsstress, Mitose und genomische Instabilität

BIOspektrum ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 10-13
Author(s):  
Alicia Konrath ◽  
Ann-Kathrin Schmidt ◽  
Holger Bastians
Keyword(s):  
Dna Replication ◽  
Tumor Progression ◽  
Chromosome Aberrations ◽  
Chromosomal Instability ◽  
Chromosome Instability ◽  
Replication Stress ◽  
Functional Link ◽  
Structural Chromosome ◽  
Genomische Instabilität

AbstractChromosomal instability (CIN) is a hallmark of cancer and contributes to tumorigenesis and tumor progression. While structural CIN (S-CIN) leads to structural chromosome aberrations, whole chromosome instability (W-CIN) is defined by perpetual gains or losses of chromosomes during mitosis causing aneuploidy. Mitotic defects, but also abnormal DNA replication (replication stress) can lead to W-CIN. However, the functional link between replication stress, mitosis and aneuploidy is little understood.

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