Inferring Genome-Wide Interaction Networks

2016 ◽  
pp. 99-117 ◽  
Author(s):  
Gökmen Altay ◽  
Onur Mendi
Keyword(s):  
Interaction Networks ◽  
Genome Wide

scholarly journals Coding-Gene Coevolution Analysis of Rotavirus Proteins: A Bioinformatics and Statistical Approach

Genes ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 28
Author(s):  
Nabil Abid ◽  
Giovanni Chillemi ◽  
Marco Salemi
Keyword(s):  
Statistical Approach ◽  
Viral Proteins ◽  
Viral Fitness ◽  
Interaction Networks ◽  
Full Genome ◽  
Genome Sequences ◽  
Potential Effectiveness ◽  
Genome Wide ◽  
Coevolution Analysis ◽  
Infants And Young Children

Rotavirus remains a major cause of diarrhea in infants and young children worldwide. The permanent emergence of new genotypes puts the potential effectiveness of vaccines under serious question. The distribution of unusual genotypes subject to viral fitness is influenced by interactions among viral proteins. The present work aimed at analyzing the genetic constellation and the coevolution of rotavirus coding genes for the available rotavirus genotypes. Seventy-two full genome sequences of different genetic constellations were analyzed using a genetic algorithm. The results revealed an extensive genome-wide covariance network among the 12 viral proteins. Altogether, the emergence of new genotypes represents a challenge to the outcome and success of vaccination and the coevolutionary analysis of rotavirus proteins may boost efforts to better understand the interaction networks of proteins during viral replication/transcription.

scholarly journals Beyond GWAS in COPD: Probing the Landscape between Gene-Set Associations, Genome-Wide Associations and Protein-Protein Interaction Networks

2014 ◽  
Vol 78 (3-4) ◽  
pp. 131-139 ◽  
Author(s):  
Merry-Lynn Noelle McDonald ◽  
Manuel Mattheisen ◽  
Michael H. Cho ◽  
Yang-Yu Liu ◽  
Benjamin Harshfield ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Protein Interaction Networks ◽  
Interaction Networks ◽  
Gene Set ◽  
Protein Protein Interaction ◽  
Genome Wide ◽  
Protein Protein Interaction Networks

Genome-wide association mapping reveals epistasis and genetic interaction networks in sugar beet

2011 ◽  
Vol 123 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Tobias Würschum ◽  
Hans Peter Maurer ◽  
Britta Schulz ◽  
Jens Möhring ◽  
Jochen Christoph Reif
Keyword(s):  
Sugar Beet ◽  
Association Mapping ◽  
Genetic Interaction ◽  
Interaction Networks ◽  
Genome Wide Association ◽  
Genome Wide
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