Network Dependency Index Stratified Subnetwork Analysis of Functional Connectomes: An Application to Autism

The Community Dependency Index (CDI) was developed due to concerns that the Barthel Index (BI) was limited as a measure of physical function in community settings. However, no studies have compared the two rating scales within multiple sclerosis (MS). The aim of this study was to determine whether, in a community-based sample of people with MS, the CDI is a better measure than the BI. BI and CDI data were collected from 90 people with MS. Four measurement properties were compared: scaling assumptions (item mean scores, corrected item-total correlations), acceptability (score distributions, floor/ceiling effects), reliability (Cronbach’s alpha) and validity (concurrent, discriminant, group differences, relative validity). Both scales satisfied recommended criteria for scaling assumptions (indicating it was legitimate to report a summed score) and internal consistency reliability (alpha-0.85). The scales were highly correlated (r- 0.96), indicating they measured the same construct. Both scales demonstrated good group differences validity, but the BI was marginally superior. Notable ceiling effects (BI-CDI) were demonstrated for both scales, particularly in those less disabled. This study sample had relatively minor levels of disability, with over 70% still being independently mobile. In this sample of people with MS, the measurement properties of the BI and CDI examined were very similar, suggesting the CDI does not appear to have achieved its goal of better measurement.

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The Determination of Multiple Steady States in Two Families of Biological Systems

Zeitschrift für Naturforschung A ◽

10.1515/zna-2004-0307 ◽

2004 ◽

Vol 59 (3) ◽

pp. 136-146

Author(s):

Guo-Syong Chuang ◽

Pang-Yen Ho ◽

Hsing-Ya Li

Keyword(s):

Steady State ◽

Transport Model ◽

Biological Systems ◽

Linear Equations ◽

Steady States ◽

Metabolic Energy ◽

Mass Action ◽

Multiple Steady States ◽

Mass Action Kinetics ◽

Subnetwork Analysis

The capacity of computational multiple steady states in two biological systems are determined by the Deficiency One Algorithm and the Subnetwork Analysis. One is a bacterial glycolysis model involving the generation of ATP, and the other one is an active membrane transport model, which is performed by pump proteins coupled to a source of metabolic energy. Mass action kinetics, is assumed and both models consist of eight coupled non-linear equations. A set of rate constants and two corresponding steady states are computed. The phenomena of bistability and hysteresis are discussed. The bifurcation of multiple steady states is also displayed. A signature of multiplicity is derived, which can be applied to mechanism identifications if steady state concentrations for some species are measured. The capacity of steady state multiplicity is extended to their families of reaction networks.

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Research Review of Origin-destination Trip Demand Estimation for Subnetwork Analysis

Procedia - Social and Behavioral Sciences ◽

10.1016/j.sbspro.2013.08.169 ◽

2013 ◽

Vol 96 ◽

pp. 1485-1493 ◽

Cited By ~ 3

Author(s):

Qionghua Deng ◽

Lin Cheng

Keyword(s):

Demand Estimation ◽

Research Review ◽

Subnetwork Analysis

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SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis

Scientific Reports ◽

10.1038/srep36257 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 10

Author(s):

Sergio Pulido-Tamayo ◽

Bram Weytjens ◽

Dries De Maeyer ◽

Kathleen Marchal

Keyword(s):

Mutual Exclusivity ◽

Driver Genes ◽

Cancer Driver ◽

Cancer Driver Genes ◽

Subnetwork Analysis

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Surveying the Importance of Population and its Demographic Profile, Responsible for the Evolution of the Natura 2000 Sites of Bihor County, Romania

Eastern European Countryside ◽

10.1515/eec-2017-0007 ◽

2017 ◽

Vol 23 (1) ◽

pp. 147-170

Author(s):

Ribana Linc ◽

Iulian Dinca ◽

Marcu Corina Tatar ◽

Liviu Bucur ◽

Keyword(s):

Protected Areas ◽

Natura 2000 ◽

Human Pressure ◽

Demographic Profile ◽

Active Population ◽

Demographic Indicators ◽

Study Results ◽

Local Residents ◽

Administrative Units ◽

Dependency Index

Abstract The current study focuses on the demographic profile research of Nature 2000 sites belonging to 28 administrative entities located in Bihor County, in northwestern Romania. For the purposes of this study, out of the 74 local administrative units (LAUs) holding protected areas of the type Nature 2000 while only sites that cover over 40% of the administrative entities’ area were taken into account. Starting from the interrelation of the contact between human communities and local ecosystems, the research sought to determine the interdependence level between the local residents’ lifestyle and the biodiversity-related maintenance/preservation of these protected areas. Based on the referenced statistics, more demographic indicators were calculated (population decrement, population density, structure by age, dependency index, active population and structure by industry) and basic indicators of pressure on the environment (naturality index, human pressure through land use and forest area per capita). Each of these factors are meant to reveal how man cohabitates with nature in a balanced or disrupted manner according to the study results. Thus, considering the 28 LAUs from case to case, areas where environmental health tends to insecurity were identified, but there are cases in which it is satisfactory thanks to the existence of massive woodlands over wide areas, while also being due to a considerable demographic decrement.

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Visuo-postural dependency index (VPDI) in human postural control

BMC Sports Science Medicine and Rehabilitation ◽

10.1186/s13102-021-00235-x ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Alessander Danna-dos-Santos ◽

Maria M. Ribeiro dos Santos ◽

Alessandra T. Magalhães ◽

Vinicius S. Cardoso ◽

Patricia Driusso ◽

...

Keyword(s):

Postural Control ◽

Temporal Frequency ◽

Gender Effects ◽

Gender And Age ◽

Visual Vertical ◽

Eyes Open ◽

Fall Risks ◽

And Gender ◽

Dependency Index ◽

Operational Methods

Abstract Background Computerized stabilometry has been utilized to investigate the effect of vision on the neuromechanisms of human postural control. However, this approach lacks operational methods to quantify visual dependency during upright stance. This study had three goals: (1) To introduce the concept of visuo-postural dependency indices (VPDI) representing balance sway characteristics in multiple analytical domains (spatial, temporal, frequency, and structural), (2) To investigate the age and gender effects on VPDIs, and (3) To investigate the degree of relationships between VPDI and both subjective visual vertical and horizontal perception (SVV and SVH, respectively). Methods 102 participants (16 to 80 years old) performed bipedal stances on a force platform with eyes open and closed. Response variables included the VPDIs computed for each postural index. In addition, 29 participants also performed SVV and SVH assessments. Results Fifteen VPDIs showed to be robust indicators of visual input modulation, and the variation across their magnitudes of modulation revealed a non-homogeneous response to changes in visual stimuli. Gender and age were not found to be a significant factor to VPDI modulation. Conclusions VPDIs revealed to be potential measures capable to quantitatively assess visuo-postural dependency and aid the assessment of fall risks and balance impairments.

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The effect of vesicular-arbuscular mycorrhizal inoculation on the growth and root colonization of ten strawberry cultivars

Agricultural and Food Science ◽

10.23986/afsci.72457 ◽

1992 ◽

Vol 1 (5) ◽

pp. 527-535 ◽

Cited By ~ 2

Author(s):

Mauritz Vestberg

Keyword(s):

Root Colonization ◽

Arbuscular Mycorrhizal ◽

Dry Weight ◽

Mycorrhizal Dependency ◽

Vam Fungi ◽

Shoot Dry Weight ◽

Vesicular Arbuscular ◽

Mycorrhizal Inoculation ◽

Dependency Index ◽

Strawberry Cultivars

Ten strawberry cultivars, four early maturing, three late maturing and three “special” cultivars, were inoculated with six strains of vesicular-arbuscular mycorrhizal (VAM) fungi in a pot experiment. Growth effects and colonization of the VAM fungi were studied. Three strains, Glomus macrocarpum V3, G. mosseae Rothamsted and G. sp. V4, were highly efficient, causing significant growth increases in most cultivars. ’Jonsok’ showed the highest mycorrhizal dependency index, 648, and ’Ostara’ the lowest, 269, for the mean response of all six fungi. The fungal strains which increased shoot growth the most also increased the runner plant formation the most. Early cultivars showed higher colonization percentages than late maturing cultivars. Sporulation of the introduced VAM fungi was on average more abundant in early and special cultivars than in late cultivars. Root colonization and strawberry shoot dry weight correlated significantly in most cultivars, but the correlation between colonization and runner formation was generally poor.

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Effects of thiamine on vasopressor requirements in patients with septic shock: a prospective randomized controlled trial

BMC Anesthesiology ◽

10.1186/s12871-020-01195-4 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Suttasinee Petsakul ◽

Sunthiti Morakul ◽

Viratch Tangsujaritvijit ◽

Parinya Kunawut ◽

Pongsasit Singhatas ◽

...

Keyword(s):

Septic Shock ◽

Sample Size ◽

Primary Outcome ◽

Controlled Trial ◽

Tertiary Hospital ◽

Double Blind ◽

Randomized Controlled ◽

Prospective Randomized Controlled Trial ◽

Significant Difference ◽

Dependency Index

Abstract Background Thiamine, an essential vitamin for aerobic metabolism and glutathione cycling, may decrease the effects of critical illnesses. The objective of this study was to determine whether intravenous thiamine administration can reduce vasopressor requirements in patients with septic shock. Methods This study was a prospective randomized double-blind placebo-controlled trial. We included adult patients with septic shock who required a vasopressor within 1–24 h after admission between March 2018 and January 2019 at a tertiary hospital in Thailand. Patients were divided into two groups: those who received 200 mg thiamine or those receiving a placebo every 12 h for 7 days or until hospital discharge. The primary outcome was the number of vasopressor-free days over 7 days. The pre-defined sample size was 31 patients per group, and the study was terminated early due to difficult recruitment. Results Sixty-two patients were screened and 50 patients were finally enrolled in the study, 25 in each group. There was no difference in the primary outcome of vasopressor-free days within the 7-day period between the thiamine and placebo groups (mean: 4.9 days (1.9) vs. 4.0 days (2.7), p = 0.197, mean difference − 0.9, 95% CI (− 2.9 to 0.5)). However, the reductions in lactate (p = 0.024) and in the vasopressor dependency index (p = 0.02) at 24 h were greater among subjects who received thiamine repletion vs. the placebo. No statistically significant difference was observed in SOFA scores within 7 days, vasopressor dependency index within 4 days and 7 days, or 28-day mortality. Conclusions Thiamine was not associated to a significant reduction in vasopressor-free days over 7-days in comparison to placebo in patients with septic shock. Administration of thiamine could be associated with a reduction in vasopressor dependency index and lactate level within 24 h. The study is limited by early stopping and low sample size. Trial registration TCTR, TCTR20180310001. Registered 8 March 2018, http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=3330.

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