Chromatin Remodeling During Leukemia Cell Proliferation and Differentiation

The Retinoblastoma protein (pRb) is a key cell cycle regulator conserved in a wide variety of organisms. Experimental analysis of pRb’s functions in animals and plants has revealed that this protein participates in cell proliferation and differentiation processes. In addition, pRb in animals and its orthologs in plants (RBR), are part of highly conserved protein complexes which suggest the possibility that analogies exist not only between functions carried out by pRb orthologs themselves, but also in the structure and roles of the protein networks where these proteins are involved. Here, we present examples of pRb/RBR participation in cell cycle control, cell differentiation, and in the regulation of epigenetic changes and chromatin remodeling machinery, highlighting the similarities that exist between the composition of such networks in plants and animals.

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Effects of Glycosaminoglycans on U-937 Leukemia Cell Proliferation and Differentiation: Structure-Function Relationship

Experimental Cell Research ◽

10.1006/excr.1994.1323 ◽

1994 ◽

Vol 215 (1) ◽

pp. 119-130 ◽

Cited By ~ 15

Author(s):

Nicola Volpi ◽

Mario Petrini ◽

Angela Conte ◽

Paola Valentini ◽

Tiziana Venturelli ◽

...

Keyword(s):

Cell Proliferation ◽

Structure Function ◽

Leukemia Cell ◽

Cell Proliferation And Differentiation ◽

Proliferation And Differentiation ◽

Structure Function Relationship ◽

Function Relationship

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Faculty Opinions recommendation of Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732284718.793547053 ◽

2018 ◽

Author(s):

Pascal Silberzan

Keyword(s):

Cell Proliferation ◽

Adhesion Forces ◽

Cortical Tension ◽

Cell Proliferation And Differentiation ◽

Proliferation And Differentiation

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Icariin Stimulates hFOB 1.19 Osteoblast Proliferation and Differentiation via OPG/RANKL Mediated by the Estrogen Receptor

Current Pharmaceutical Biotechnology ◽

10.2174/1389201021666200123102550 ◽

2020 ◽

Vol 22 (1) ◽

pp. 168-175 ◽

Cited By ~ 1

Author(s):

Lin-Jun Sun ◽

Chong Li ◽

Xiang-hao Wen ◽

Lu Guo ◽

Zi-Fen Guo ◽

...

Keyword(s):

Cell Proliferation ◽

Estrogen Receptor ◽

Protein Expression ◽

Chinese Herb ◽

Human Osteoblast ◽

Osteoblast Cells ◽

Expression Ratio ◽

Cell Proliferation And Differentiation ◽

Proliferation And Differentiation ◽

Mrna And Protein Expression

Background:: Icariin (ICA), one of the main effective components isolated from the traditional Chinese herb Epimedium brevicornu Maxim., has been reported to possess extensive pharmacological actions, including enhanced sexual function, immune regulation, anti-inflammation, and antiosteoporosis. Methods:: Our study was designed to investigate the effect of ICA on cell proliferation and differentiation and the molecular mechanism of OPG/RANKL mediated by the Estrogen Receptor (ER) in hFOB1.19 human osteoblast cells. Results:: The experimental results show that ICA can stimulate cell proliferation and increase the activity of Alkaline Phosphatase (ALP), Osteocalcin (BGP) and I Collagen (Col I) and a number of calcified nodules. Furthermore, the mRNA and protein expression of OPG and RANKL and the OPG/ RANKL mRNA and protein expression ratios were upregulated by ICA. The above-mentioned results indicated that the optimal concentration of ICA for stimulating osteogenesis was 50ng/mL. Subsequent mechanistic studies comparing 50ng/mL ICA with an estrogen receptor antagonist demonstrated that the effect of the upregulated expression is connected with the estrogen receptor. In conclusion, ICA can regulate bone formation by promoting cell proliferation and differentiation and upregulating the OPG/RANKL expression ratio by the ER in hFOB1.19 human osteoblast cells.

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Costimulation by B7 Modulates Specificity of Cytotoxic T Lymphocytes: A Missing Link That Explains Some Bystander T Cell Activation

Journal of Experimental Medicine ◽

10.1084/jem.186.10.1787 ◽

1997 ◽

Vol 186 (10) ◽

pp. 1787-1791 ◽

Cited By ~ 10

Author(s):

Pan Zheng ◽

Yang Liu

Keyword(s):

Cell Proliferation ◽

T Cells ◽

Influenza Virus ◽

T Cell ◽

T Cell Activation ◽

Cell Activation ◽

T Cell Proliferation ◽

Target Cells ◽

Cell Proliferation And Differentiation ◽

Proliferation And Differentiation

It has been proposed that some bystander T cell activation may in fact be due to T cell antigen receptor (TCR) cross-reactivity that is too low to be detected by the effector cytotoxic T lymphocyte (CTL). However, this hypothesis is not supported by direct evidence since no TCR ligand is known to induce T cell proliferation and differentiation without being recognized by the effector CTL. Here we report that transgenic T cells expressing a T cell receptor to influenza virus A/NT/68 nucleoprotein (NP) 366-374:Db complexes clonally expand and become effector CTLs in response to homologous peptides from either A/PR8/34 (H1N1), A/AA/60 (H2N2), or A/NT/68 (H3N2). However, the effector T cells induced by each of the three peptides kill target cells pulsed with NP peptides from the H3N2 and H2N2 viruses, but not from the H1N1 virus. Thus, NP366–374 from influenza virus H1N1 is the first TCR ligand that can induce T cell proliferation and differentiation without being recognized by CTLs. Since induction of T cell proliferation was mediated by antigen-presenting cells that express costimulatory molecules such as B7, we investigated if cytolysis of H1N1 NP peptide–pulsed targets can be restored by expressing B7-1 on the target cells. Our results revealed that this is the case. These data demonstrated that costimulatory molecule B7 modulates antigen specificity of CTLs, and provides a missing link that explains some of the bystander T cell activation.

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