Impact of Behavioral Adversities During Life on Individual’s Long-Term Health Status—A Three-Year Follow-up of 403 Middle-Aged PEP—Participants

2022 ◽  
pp. 75-103
Author(s):  
Gerda-Maria Haas ◽  
Peter Schwandt
Keyword(s):  
Health Status ◽  
Middle Aged

Abstract P116: Trait Anger Increases Short-term and Long-term Risk for Recurrent CHD: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Janice E Williams ◽  
Sharon B Wyatt ◽  
Kathryn M Rose ◽  
David J Couper ◽  
Anna Kucharska-Newton
Keyword(s):  
Cigarette Smoking ◽  
Trait Anger ◽  
Middle Aged ◽  
Short Term ◽  
Men And Women ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

Though several large epidemiologic studies have demonstrated the positive association of anger with coronary heart disease (CHD) onset, a dearth of population-based evidence exists regarding the relationship of anger to the clinical course of CHD among people with established disease. Trait anger is conceptualized as a stable personality trait and defined as the tendency to experience frequent and intense anger. Therefore, it is plausible that the effects of trait anger on CHD are long standing. We assessed the hypothesis that trait anger predicts short-term and long-term risk for recurrent CHD among middle-aged men and women. Participants were 611 black or white men and women, ages 48 - 67, who had a history of CHD at the second clinical examination (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) Study. They were followed for the recurrence of CHD (myocardial infarction or fatal CHD) from 1990 through three different time intervals: 1995, 2003, and 2009 (maximum follow-up = 19.0 years). Trait anger (measured at Visit 2) was assessed using the Spielberger Trait Anger Scale, with scores categorized as high, moderate, and low. Cox proportional hazards regression analyses were adjusted for age, sex, race-center, educational level, waist-to-hip ratio, plasma LDL-and HDL-cholesterol levels, hypertension, diabetes, cigarette smoking status, and pack-years of cigarette smoking. After 3 - 5 years of follow-up, the risk for recurrent CHD among participants with high trait anger was more than twice that of their counterparts with low trait anger (2.24 [95% C.I: 1.14 to 4.40]). After 11 - 13 years, the risk was 80% greater (1.80 [95% C.I: 1.17 to 2.78]) and after 17 - 19 years, it was 70% greater (1.70 [95% C.I: 1.15 to 2.52]). The risk for recurrent CHD was strongest in the first time interval but remained strong and statistically significant through 19 years of follow-up. In conclusion, the experience of frequent and intense anger increases short-term and long-term risk for recurrent CHD in middle-aged men and women.

Long-Term Follow-Up of Controlled Acromegalic Patients: Radiotherapy Is Associated with Impaired Subjective Health Status (SF-36)

2011 ◽  
pp. P3-285-P3-285
Author(s):  
Sandra Schindler ◽  
Matthias Mohlig ◽  
Natalia Kremenevskaya ◽  
Michael Buchfelder ◽  
Christof Schofl
Keyword(s):  
Health Status ◽  
Subjective Health ◽  
Subjective Health Status ◽  
Sf 36 ◽  
Long Term Follow Up

scholarly journals The health status of Q-fever patients after long-term follow-up

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Gabriëlla Morroy ◽  
Jeannette B Peters ◽  
Malou van Nieuwenhof ◽  
Hans HJ Bor ◽  
Jeannine LA Hautvast ◽  
...  
Keyword(s):  
Health Status ◽  
Q Fever ◽  
Long Term Follow Up

Long-term efficacy and safety of enzalutamide (ENZ) monotherapy in hormone-naïve prostate cancer (HNPC): 3-year, open-label, follow-up results.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 220-220
Author(s):  
Bertrand F. Tombal ◽  
Michael Borre ◽  
Per Rathenborg ◽  
Patrick Werbrouck ◽  
Hendrik Van Poppel ◽  
...  
Keyword(s):  
Health Status ◽  
Global Health ◽  
Specific Antigen ◽  
Global Health Status ◽  
Mineral Density ◽  
Hot Flush ◽  
Psa Response ◽  
Total Body

220 Background: A phase 2 study of the androgen receptor inhibitor ENZ as monotherapy in patients with HNPC [NCT01302041] showed a high prostate-specific antigen (PSA) response rate, regardless of baseline metastases, and favorable tolerability. In a 1- and 2-year follow-up, ENZ maintained long-term reductions from baseline in PSA, with minimal impact on total-body bone mineral density (BMD). Herein, results from a pre-specified 3-year follow-up are reported. Methods: A total of67 patients with HNPC and non-castrate testosterone ( ≥ 230 ng/dL) received ENZ 160 mg/day until disease progression or unacceptable toxicity. The primary end point of PSA response ( ≥ 80% decline from baseline) was analyzed at week 25 and 1, 2, and 3 years. Other end points were best overall tumor response, BMD, body composition, quality of life, and safety. Results: At the 3-year visit, 42 (62.7%) patients remained on the study medication. Of those, 38 (90.5%; 95% confidence interval 77.4%, 97.3%) maintained a PSA response. Of the 26 patients with metastases at baseline, 17 (65.4%) had a complete or partial response as best overall response at 3 years. In patients who completed the 3-year visit, minimal changes from baseline were observed in total-body BMD or in BMD of the femoral neck, trochanter, spine L1–L4, or forearm (median and mean changes ranged from –3.6% to 1.3% and –2.7% to –0.1%, respectively). The EORTC QLQ-C30 global health status results showed a small decrease at 3 years versus baseline (–3.96 points), consistent with the 2-year results. At 3 years, measurements for total body fat increased (median, 14.7%; mean, 16.5%) and total body lean decreased (median, –6.3%; mean, –6.5%) from baseline. Physical functioning, fatigue, and dyspnea worsened ( > 10 points) at 3 years, similar to results at 2 years. The most frequently reported adverse events ( > 10%) were gynecomastia, fatigue, hot flush, nipple pain, hypertension, diarrhea, nausea, pain in extremity, back pain, and constipation. Conclusions: In patients with HNPC treated with ENZ for 3 years, the efficacy of ENZ as monotherapy was maintained. Overall, BMD, global health status, and safety results were similar to those at 2 years. Clinical trial information: NCT01302041.

One-year community-based education program for hypercholesterolemia in middle-aged Japanese: a long-term outcome at 8-year follow-up

2002 ◽  
Vol 164 (1) ◽  
pp. 195-202 ◽  
Author(s):  
Hiroyasu Iso ◽  
Hironori Imano ◽  
Yuko Nakagawa ◽  
Masahiko Kiyama ◽  
Akihiko Kitamura ◽  
...  
Keyword(s):  
Education Program ◽  
Middle Aged ◽  
Community Based ◽  
Term Outcome ◽  
Community Based Education ◽  
Long Term Outcome ◽  
One Year

scholarly journals Chronic Pain And Depressive Symptoms In Chinese Middle-Aged And Older Adults:A Follow Up Study

2021 ◽  
Author(s):  
Jialin Liu ◽  
Zixuan Chen ◽  
Yuke Yu ◽  
Qin Wang ◽  
Xiuxiu Liu ◽  
...  
Keyword(s):  
Older Adults ◽  
Chronic Pain ◽  
Depressive Symptoms ◽  
Health Status ◽  
Elderly People ◽  
Elderly Care ◽  
Univariate Analysis ◽  
Depression Scale ◽  
Middle Aged

Abstract Objective: This study aimed to analyze the effects of chronic pain on the occurrence of depressive symptoms in Chinese middle-aged and older adults, and to provide a scientific basis for reducing the incidence of depressive symptoms, improving the quality of life in middle-aged and older adults, and reducing the disease burden in the aging population.Methods: a prospective study was conducted to select adults aged 45 years or older from the longitudinal study of China Health and elderly care follow-up survey (Charls) (2015 and 2018). Pain was assessed according to the patient's self exposure, and depression was assessed using the Chinese version of the center for epidemiological research Depression Scale (CES-D). Univariate analysis and binary logistic regression model were used for analysis. Results: The 3-year cumulative incidence of depression in chronic pain patients was 52.4% and the annual incidence was 17.5% in the middle-aged and elderly Chinese population. Univariate analysis showed statistically significant differences in the incidence of depressive symptoms between the different genders, age, residence, education level, marriage, self perceived health status, nocturnal sleep time, number of social activities in the past month, smoking, alcohol consumption, impaired ADL and Medicare insurance coverage. This study, after controlling for demographic characteristics, health status and health behaviors, Different pain conditions remained statistically significant for depression in middle-aged and older adults. Compared with middle-aged and older adults without pain, both Unisomatic pain (OR = 1.388) and Multiple somatic pain (OR= 1.869) increased the risk of depression in the middle-aged and older populations. Conclusion: chronic pain is associated with the risk of depressive symptoms in middle-aged and elderly people, and the incidence of depression in middle-aged and elderly people in China is not optimistic.

Impact of obesity and physical inactivity on the long-term change in grip strength among middle-aged and older European adults

2019 ◽  
Vol 73 (7) ◽  
pp. 619-624 ◽  
Author(s):  
Tianyu Wang ◽  
Wenjing Feng ◽  
Suyun Li ◽  
Qihua Tan ◽  
Dongfeng Zhang ◽  
...  
Keyword(s):  
Grip Strength ◽  
Chronic Conditions ◽  
Physical Inactivity ◽  
Middle Aged ◽  
Physically Active ◽  
Term Change ◽  
All Cause Mortality ◽  
Gender Specific

BackgroundGrip strength is a well-established predictor of various chronic conditions and all-cause mortality. Body weight and physical activity (PA) are considered potential determinants of muscle strength. This study aimed to investigate gender-specific associations of baseline obesity and physical inactivity with long-term changes in grip strength among middle-aged and older European adults.MethodsData from the Survey of Health, Ageing and Retirement in Europe 2004–2015 which was conducted in 12 countries were analysed. Grip strength was repeatedly measured at five follow-up visits with average 2-year intervals. Obesity and physical inactivity at baseline were primary exposures. Generalised estimated equations stratified by gender were fitted.ResultsThis study included 8616 males and 10 088 females with a median follow-up of 9.42 years. Significant interactions between obesity and time with grip strength were identified in both males (χ2interaction=16.65, p = 0.002) and females (χ2interaction=10.80, p = 0.029). No significant interaction between physical inactivity and time with grip strength was identified in males (χ2interaction=9.42, p = 0.051) or females (χ2interaction=5.62, p = 0.230). Those who were less physically active at baseline had weaker grip strength from the beginning at baseline (β = −2.753, p < 0.001 for males and β = −1.529, p < 0.001 for females) to Visit 6 (β = −2.794, p < 0.001 for males and β = −1.550, p < 0.001 for females). Further combined analysis suggested a trend that exposure to both obesity and physical inactivity was related to the fastest decline rate of grip strength.ConclusionsThis study provides the additional evidence that PA and obesity prevention earlier in life play an important role in maintaining grip strength during ageing.

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