Improved Polymer Functionality by Cross-linking with Glutaraldehyde to Achieve Controlled Drug Release

Abstract Drug-loading hydrogels were prepared from O-carboxymethyl chitosan (O-CMCS) with a high degree of substitution and different deacetylation degree (DD) using acetylsalicylic acid as drug and glutaraldehyde as a cross-linking agent. Also, the DD’s effect on the controlled drug release performance of drug-loading particle was explored. The results showed that the hydrogels and particles were prepared from 5 g of O-CMCS solution (4.0 wt.%), 2.5 g of sodium acetylsalicylate solution (8.0 wt.%), and 1.5 mL of glutaraldehyde solution (1.0 wt.%). The interior pore size of the particle (DD = 51%) was between 50 and 100µm, and its cumulative drug release ratios in the simulated gastric and intestinal juices were of the top values. The drug release of the drug-loading particle was proved to be obviously pH sensitive and it can be applied as a colonic drug.

Download Full-text

A cross-linking graphene oxide–polyethyleneimine hybrid film containing ciprofloxacin: one-step preparation, controlled drug release and antibacterial performance

Journal of Materials Chemistry B ◽

10.1039/c4tb01896f ◽

2015 ◽

Vol 3 (8) ◽

pp. 1605-1611 ◽

Cited By ~ 30

Author(s):

Tiefan Huang ◽

Lin Zhang ◽

Huanlin Chen ◽

Congjie Gao

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Drug Release ◽

Hybrid Film ◽

Controlled Drug Release ◽

Cross Linking ◽

Antibacterial Performance ◽

One Step ◽

Novel Drug Delivery System ◽

Novel Drug

A graphene oxide film was cross-linked by polyethyleneimine as a novel drug delivery system which showed excellent antibacterial performance.

Download Full-text

Modeling a system of phosphated cross-linked high amylose for controlled drug release. Part 2: Physical parameters, cross-linking degrees and drug delivery relationships

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2008.12.010 ◽

2009 ◽

Vol 371 (1-2) ◽

pp. 8-15 ◽

Cited By ~ 27

Author(s):

B.S.F. Cury ◽

A.D. Castro ◽

S.I. Klein ◽

R.C. Evangelista

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Controlled Drug Release ◽

Cross Linking ◽

Physical Parameters ◽

High Amylose

Download Full-text

Evaluation of Swelling Process of Various Natural Polymer Matrix Tablets by X-ray Computed Tomography and Their Controlled Drug Release

10.26226/morressier.57d6b2bbd462b8028d88d91d ◽

2016 ◽

Author(s):

Makoto Otsuka

Keyword(s):

Computed Tomography ◽

Drug Release ◽

Polymer Matrix ◽

Controlled Drug Release ◽

Matrix Tablets ◽

Natural Polymer ◽

X Ray ◽

X Ray Computed

Download Full-text

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

Revista de Chimie ◽

10.37358/rc.17.12.6008 ◽

2018 ◽

Vol 68 (12) ◽

pp. 2925-2918

Author(s):

Gabriela Cioca ◽

Maricel Agop ◽

Marcel Popa ◽

Simona Bungau ◽

Irina Butuc

Keyword(s):

Drug Release ◽

Tannic Acid ◽

Release Rate ◽

Controlled Drug Release ◽

Toxicity Threshold ◽

Release System ◽

Liposomal Formulations ◽

Cross Linker ◽

Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Download Full-text

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

Current Nanoscience ◽

10.2174/1573413714666180222134742 ◽

2018 ◽

Vol 14 (5) ◽

pp. 432-439 ◽

Cited By ~ 1

Author(s):

Juliana M. Juarez ◽

Jorgelina Cussa ◽

Marcos B. Gomez Costa ◽

Oscar A. Anunziata

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Therapeutic Efficacy ◽

Drug Delivery Systems ◽

Controlled Drug Release ◽

Delivery Systems ◽

The Body ◽

Fickian Diffusion ◽

Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Download Full-text