Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

DNA-capped Fe3O4/SiO2 magnetic mesoporous silica (MMS) nanoparticles were developed for potential temperature controlled drug release and magnetic hyperthermia.

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Effective Cancer Theranostics with Polymer Encapsulated Superparamagnetic Nanoparticles: Combined Effects of Magnetic Hyperthermia and Controlled Drug Release

ACS Biomaterials Science & Engineering ◽

10.1021/acsbiomaterials.6b00420 ◽

2016 ◽

Vol 3 (7) ◽

pp. 1332-1340 ◽

Cited By ~ 27

Author(s):

Nanasaheb D. Thorat ◽

Raghvendra A. Bohara ◽

Mohamed Radzi Noor ◽

Dinesh Dhamecha ◽

Tewfik Soulimane ◽

...

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Magnetic Hyperthermia ◽

Superparamagnetic Nanoparticles ◽

Combined Effects ◽

Cancer Theranostics

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Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

International Journal of Molecular Sciences ◽

10.3390/ijms21103641 ◽

2020 ◽

Vol 21 (10) ◽

pp. 3641 ◽

Cited By ~ 3

Author(s):

Beatriz D. Cardoso ◽

Ana Rita O. Rodrigues ◽

Bernardo G. Almeida ◽

Carlos O. Amorim ◽

Vítor S. Amaral ◽

...

Keyword(s):

Magnetic Field ◽

Drug Release ◽

Natural Compound ◽

Controlled Drug Release ◽

Magnetic Hyperthermia ◽

Ferrite Nanoparticles ◽

Pharmacological Properties ◽

Magnesium Ferrite ◽

Superparamagnetic Properties ◽

Over Time

Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1−xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.

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Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

Journal of Research in Nanoscience and Nanotechnology ◽

10.37934/jrnn.2.1.5160 ◽

2021 ◽

Vol 2 (1) ◽

pp. 51-60

Author(s):

Mostafa Yusefi ◽

Kamyar Shameli ◽

Siti Nur Amalina Mohamad Sukri

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Drug Release ◽

Controlled Drug Release ◽

Magnetic Hyperthermia ◽

Alternating Magnetic Field ◽

Tumor Type ◽

Heating Efficiency ◽

Heating Source ◽

Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

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Biodegradable magnetic microspheres for drug targeting, temperature controlled drug release, and hyperthermia

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2019-0041 ◽

2019 ◽

Vol 5 (1) ◽

pp. 161-164 ◽

Cited By ~ 4

Author(s):

Diana Zahn ◽

Andreas Weidner ◽

Katayoun Saatchi ◽

Urs O. Häfeli ◽

Silvio Dutz

Keyword(s):

Drug Release ◽

Drug Targeting ◽

Matrix Material ◽

Controlled Drug Release ◽

Magnetic Hyperthermia ◽

Magnetic Microspheres ◽

Magnetic Drug Targeting ◽

Target Area ◽

Water Emulsion ◽

Oil In Water Emulsion

AbstractMagnetic microspheres (MMS) used for magnetic drug targeting consist of magnetic nanoparticles (MNP) and a pharmaceutical agent embedded in a polymeric matrix material. The application of MNP for drug targeting enables guiding the MMS to a target area, imaging the position of the MMS with magnetic particle imaging, and finally inducing drug release. As latter takes place by degradation of the MMS or diffusion through the matrix, an increase in temperature, e.g. through magnetic hyperthermia, leads to an accelerated drug release. Here, MMS consisting of poly(lactic-coglycolic) acid (PLGA) with different monomer ratios were prepared by an oil-in-water emulsion evaporation method. The model drug Camptothecin (CPT) and magnetic multicore nanoparticles (MCNP) with a high specific heating rate were embedded into the microspheres. We obtained MMS in the preferred size range of 1 to 2 μm with a concentration of MCNP of 16wt%, a drug load of about 0.5wt% and an excellent heating performance of 161 W/gMMS. Investigations of the drug release behaviour showed an accelerated drug release when increasing the temperature from 20 °C to 37 °C or 43 °C by using a water bath. In addition, an increase in drug release of about 50% through magnetic heating of the MMS up to 44 °C compared to 37 °C was observed. By this, a magnetic hyperthermia induced CPT release from PLGA MMS is demonstrated for the very first time.

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Evaluation of Swelling Process of Various Natural Polymer Matrix Tablets by X-ray Computed Tomography and Their Controlled Drug Release

10.26226/morressier.57d6b2bbd462b8028d88d91d ◽

2016 ◽

Author(s):

Makoto Otsuka

Keyword(s):

Computed Tomography ◽

Drug Release ◽

Polymer Matrix ◽

Controlled Drug Release ◽

Matrix Tablets ◽

Natural Polymer ◽

X Ray ◽

X Ray Computed

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Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

Revista de Chimie ◽

10.37358/rc.17.12.6008 ◽

2018 ◽

Vol 68 (12) ◽

pp. 2925-2918

Author(s):

Gabriela Cioca ◽

Maricel Agop ◽

Marcel Popa ◽

Simona Bungau ◽

Irina Butuc

Keyword(s):

Drug Release ◽

Tannic Acid ◽

Release Rate ◽

Controlled Drug Release ◽

Toxicity Threshold ◽

Release System ◽

Liposomal Formulations ◽

Cross Linker ◽

Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

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Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

Current Nanoscience ◽

10.2174/1573413714666180222134742 ◽

2018 ◽

Vol 14 (5) ◽

pp. 432-439 ◽

Cited By ~ 1

Author(s):

Juliana M. Juarez ◽

Jorgelina Cussa ◽

Marcos B. Gomez Costa ◽

Oscar A. Anunziata

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Therapeutic Efficacy ◽

Drug Delivery Systems ◽

Controlled Drug Release ◽

Delivery Systems ◽

The Body ◽

Fickian Diffusion ◽

Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

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Improvement of Medication Adherence and Controlled Drug Release by Optimized Acetaminophen Formulation

Macromolecular Research ◽

10.1007/s13233-021-9040-5 ◽

2021 ◽

Author(s):

Suyoung Been ◽

Jeongmin Choi ◽

Young Hun Lee ◽

Pil Yun Kim ◽

Won Kyung Kim ◽

...

Keyword(s):

Medication Adherence ◽

Drug Release ◽

Controlled Drug Release

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Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

International Journal of Molecular Sciences ◽

10.3390/ijms22010154 ◽

2020 ◽

Vol 22 (1) ◽

pp. 154

Author(s):

Fasih Bintang Ilhami ◽

Kai-Chen Peng ◽

Yi-Shiuan Chang ◽

Yihalem Abebe Alemayehu ◽

Hsieh-Chih Tsai ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Drug Release ◽

Visible Light ◽

Cancer Cells ◽

Laser Irradiation ◽

Reactive Oxygen ◽

Controlled Drug Release ◽

Grand Challenge ◽

Supramolecular System ◽

Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

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