LC-MSE for Qualitative and Quantitative Proteomic Studies of Psychiatric Disorders

2017 ◽  
pp. 115-129
Author(s):  
Mariana Fioramonte ◽  
Paul C. Guest ◽  
Daniel Martins-de-Souza
Keyword(s):  
Psychiatric Disorders ◽  
Qualitative And Quantitative

Psychological Concomitants of Cortisone and Acth Therapy

1953 ◽  
Vol 99 (416) ◽  
pp. 497-504 ◽  
Author(s):  
Linford Rees
Keyword(s):  
Adrenal Gland ◽  
Psychiatric Disorders ◽  
Adrenal Cortex ◽  
Adrenocortical Function ◽  
Adaptation To Stress ◽  
Qualitative And Quantitative ◽  
Classical Work ◽  
Acth Therapy

During recent years renewed interest has been taken in the possible importance of adrenocortical function in psychiatric disorders. Psychiatric syndromes and symptoms associated with pathological functioning of the adrenal cortex found in Cushing's and Addison's diseases have been recognized for many years. The classical work of Selye (1949) and his school has elucidated the importance of the adrenal gland in the individual's reaction and adaptation to stress. Qualitative and quantitative abnormalities in adrenocortical responsivity to stresses and stimuli in various psychiatric disorders have been reported in recent years (Freeman et al., 1944; Hoagland et al., 1946; Pincus and Elmadjean, 1946; Pincus et al., 1949).

What's in a model? Network models as tools instead of representations of what psychiatric disorders really are

2019 ◽  
Vol 42 ◽  
Author(s):  
Hanna M. van Loo ◽  
Jan-Willem Romeijn
Keyword(s):  
Psychiatric Disorders ◽  
Network Models ◽  
Model Network

AbstractNetwork models block reductionism about psychiatric disorders only if models are interpreted in a realist manner – that is, taken to represent “what psychiatric disorders really are.” A flexible and more instrumentalist view of models is needed to improve our understanding of the heterogeneity and multifactorial character of psychiatric disorders.

Expression of laminin and beta-1 integrin in embryonic, neonatal, and adult rat heart

1991 ◽  
Vol 49 ◽  
pp. 182-183
Author(s):  
R.L. Price ◽  
T.K. Borg ◽  
L. Terracio ◽  
M. Nakagawa
Keyword(s):  
Temporal Expression ◽  
Qualitative And Quantitative ◽  
Adult Rat ◽  
Cytoplasmic Face ◽  
Extracellular Matrix Components ◽  
Basement Membrane Component ◽  
Beta 1 Integrin ◽  
Quantitative Changes ◽  
Cytoskeletal Elements ◽  
External Face

Little is known about the temporal expression of extracellular matrix components (ECM) and its receptors during development of the heart. Recent reports have shown that ECM components undergo both qualitative and quantitative changes during development, and it is believed that ECM components are important in the regulation of cell migration and cell:cell and cell:ECM recognition and adhesion.Integrins are transmembrane glycoproteins which bind several ECM components on their external face and cytoskeletal elements on the cytoplasmic face. Laminin is a basement membrane component which has been recognized as an important site for cell adhesion. Both the integrins and laminin are expressed early in development and continue to be expressed in the adult heart. With their documented roles in cell recognition, and cell:cell and cell:ECM migration and adhesion these proteins appear to be important components in development of the heart, and their temporal expression may play a pivotal role in morphogenesis and myofibrillogenesis of the heart.

In situ microprobe quantitation of inorganic particle burden in paraffin sections of lung tissue

1988 ◽  
Vol 46 ◽  
pp. 990-991
Author(s):  
Jerrold L. Abraham
Keyword(s):  
Lung Tissue ◽  
Quantitative Information ◽  
Particulate Material ◽  
Paraffin Sections ◽  
Tissue Samples ◽  
Qualitative And Quantitative ◽  
The Past ◽  
Quantitative Analyses ◽  
Data Result

Inorganic particulate material of diverse types is present in the ambient and occupational environment, and exposure to such materials is a well recognized cause of some lung disease. To investigate the interaction of inhaled inorganic particulates with the lung it is necessary to obtain quantitative information on the particulate burden of lung tissue in a wide variety of situations. The vast majority of diagnostic and experimental tissue samples (biopsies and autopsies) are fixed with formaldehyde solutions, dehydrated with organic solvents and embedded in paraffin wax. Over the past 16 years, I have attempted to obtain maximal analytical use of such tissue with minimal preparative steps. Unique diagnostic and research data result from both qualitative and quantitative analyses of sections. Most of the data has been related to inhaled inorganic particulates in lungs, but the basic methods are applicable to any tissues. The preparations are primarily designed for SEM use, but they are stable for storage and transport to other laboratories and several other instruments (e.g., for SIMS techniques).

Psychiatric Disorders Inherited Separately From Atopy

2005 ◽  
Vol 36 (2) ◽  
pp. 63
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Psychiatric Disorders

Qualitative and quantitative assessment of nailfold capillaries by capillaroscopy in healthy volunteers

VASA ◽  
2012 ◽  
Vol 41 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Hoerth ◽  
Kundi ◽  
Katzenschlager ◽  
Hirschl
Keyword(s):  
Scoring System ◽  
Morphological Changes ◽  
Connective Tissue Diseases ◽  
Capillary Density ◽  
Diagnostic Value ◽  
Healthy Individuals ◽  
Extreme Position ◽  
Qualitative And Quantitative ◽  
Diffuse Loss ◽  
Density Results

Background: Nailfold capillaroscopy (NVC) is a diagnostic tool particularly useful in the differential diagnosis of rheumatic and connective tissue diseases. Although successfully applied since many years, little is known about prevalence and distribution of NVC changes in healthy individuals. Probands and methods: NVC was performed in 120 individuals (57 men and 63 women; age 18 to 70 years) randomly selected according to predefined age and sex strata. Diseases associated with NVC changes were excluded. The nailfolds of eight fingers were assessed according to standardized procedures. A scoring system was developed based on the distribution of the number of morphologically deviating capillaries, microhaemorrhages, and capillary density. Results: Only 18 individuals (15 %) had no deviation in morphology, haemorrhages, or capillary density on any finger. Overall 67 % had morphological changes, 48 % had microhaemorrhages, and 40 % of volunteers below 40 years of age and 18 % above age 40 had less than 8 capillaries/mm. Among morphological changes tortous (43 %), ramified (47 %), and bushy capillaries (27 %) were the most frequently altered capillary types. A semiquantitative scoring system was developed in such a way that a score above 1 indicates an extreme position (above the 90th percentile) in the distribution of scores among healthy individuals. Conclusions: Altered capillaries occur frequently among healthy individuals and should be interpreted as normal unless a suspicious increase in their frequency is determined by reference to the scoring system. Megacapillaries and diffuse loss of capillaries were not found and seem to be of specific diagnostic value.

Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Tamás Zonda
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Suicide Rate ◽  
Risk Groups ◽  
The Elderly ◽  
Female Ratio ◽  
Suicide Notes ◽  
Suicidal Intention ◽  
Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

Sati

Crisis ◽  
2005 ◽  
Vol 26 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Dinesh Bhugra
Keyword(s):  
Mental Illness ◽  
Psychiatric Disorders ◽  
Indian Subcontinent ◽  
Cultural Factors ◽  
Role Expectations ◽  
Prevention Strategies ◽  
Social Causation ◽  
Gender Role Expectations ◽  
Good Wife ◽  
And Gender

Abstract. Sati as an act of ritual suicide has been reported from the Indian subcontinent, especially among the Hindus, for several centuries. Although legally proscribed, these acts occur even now in modern India. The principle behind such acts has been put forward as the principle of good wife. There is little evidence to suggest that women who commit this act suffer from a formal mental illness. Cultural factors and gender role expectations play a significant role in the act and its consequences. Using recent examples, this paper illustrates the cultural factors, which may be seen as contributing to the act of suicide. Other factors embedded in the act also emphasize that not all suicides have underlying psychiatric disorders and clinicians must take social causation into account while preparing any prevention strategies.

Review of Biological bases of psychiatric disorders.

1978 ◽  
Vol 23 (10) ◽  
pp. 777-777
Author(s):  
RICHARD F. THOMPSON
Keyword(s):  
Psychiatric Disorders
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