Vitamin D and Infectious Diseases

Author(s):  
Christian Wejse ◽  
Cecilie Blenstrup Patsche

2009 ◽  
Vol 15 (5) ◽  
pp. 438-449 ◽  
Author(s):  
Alexandra Yamshchikov ◽  
Nirali Desai ◽  
Henry Blumberg ◽  
Thomas Ziegler ◽  
Vin Tangpricha


2015 ◽  
Vol 93 (5) ◽  
pp. 363-368 ◽  
Author(s):  
Richard R. Watkins ◽  
Tracy L. Lemonovich ◽  
Robert A. Salata

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions.



HORMONES ◽  
2019 ◽  
Vol 18 (4) ◽  
pp. 353-363 ◽  
Author(s):  
Dimitra Zisi ◽  
Anna Challa ◽  
Alexandros Makis


2020 ◽  
Vol 26 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Xuedi Li ◽  
Alicia Caroline Jarosz ◽  
Ahmed El-Sohemy ◽  
Alaa Badawi

Background: Genetic and nutritional factors play an important role in inflammatory response and diseases. CXCL10 is a critical biomarker that is involved in multiple inflammatory diseases, and elevated levels of CXCL10 have been associated with the development of several chronic and infectious diseases. In contrast, micronutrients can attenuate inflammatory responses. Single nucleotide polymorphisms in the pro-inflammatory cytokine genes such as IL-1β at rs16944 contributed to a number of inflammatory disorders and may substantiate the convergance between chronic and infectious diseases. Aim: This study aims to identify the modifying effect of nutritional factors on the association between IL-1β genotypes and CXCL10 levels. Methods: Participants ( N = 386) were healthy males and females from the Toronto Nutrigenomics and Health study recruited from the University of Toronto. Levels of micronutrients and inflammatory markers were measured in plasma. IL-1β genotypes were extracted from the Affymetrix 6.0 SNP chip. Results: CXCL10 levels were not different across different IL-1β genotypes. Among those with the GA genotype, elevated CXCL10 levels were observed with higher than median ascorbic acid (β = 0.004 ± 0.002, P = 0.047) or higher than median vitamin D status (β = 0.003 ± 0.002, P = 0.044). Among participants with the AA genotype, subjects with low α-tocopherol status had elevated levels of CXCL10 (β = −0.016 ± 0.007, P = 0.012). Conclusion: The association between IL-1β rs16944 genotype and CXCL10 levels was modified by the levels of ascorbic acid, α-tocopherol and vitamin D. These findings may aid in understanding the combined effect of genetic and dietary factors in the development of various infectious and chronic diseases in which IL-1β and CXCL10 may play an etiological role.



2014 ◽  
Vol 14 (4) ◽  
pp. 267-271 ◽  
Author(s):  
Giuseppe Miragliotta ◽  
Luisa Miragliotta


2018 ◽  
Vol 16 (3) ◽  
pp. 69-78 ◽  
Author(s):  
I.N. Zakharova ◽  
◽  
L.Ya. Klimov ◽  
A.N. Kasyanova ◽  
V.A. Kuryaninova ◽  
...  


2020 ◽  
Vol 18 (1) ◽  
pp. 77-84
Author(s):  
S.V. Nikolaeva ◽  
◽  
D.V. Usenko ◽  
E.K. Shushakova ◽  
O.A. Savvateeva ◽  
...  




2021 ◽  
Vol 9 (2) ◽  
pp. 80-88
Author(s):  
Jase Grimm

A diet rich in vitamin D. Bacteria, antibiotics, and metabolism Vitamin D deficiency viral microbiomes Gut Microbiome and Vitamin D. B vitamin deficiency results from malabsorption. SIF complex indirectly enhances B12 absorption. This complex gives the ileum vitamin B12. Anti-infective properties of B12 and D. B12 and D seem to slow Lachnospiraceae growth. P-cresol, butyrate, propionate Lachnospira is linked to low B12 and D levels. Debatable value. Processed foods do. B12 and D stop Blautia growth. IBD B12 deficiency IBD vitamin D Lactobacillus was infrequent, whereas E. coli was common. This present study revealed that IPA, an antioxidant, has been associated with diabetes and Alzheimer's. IPA beats melatonin. It doesn't appear to stop Alzheimer's or diabetes. Flavonoids and neuroprotective viruses D and B12 metabolism may involve Blautia. Deficiency of B12 and D in Crohn's. It reduced butyrate production. Inflammation, atherosclerosis, and immunological maturation may be cured by these nutrients.



2016 ◽  
Vol 3 (4) ◽  
pp. 139-144
Author(s):  
Chris M. Florkowski


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