scholarly journals Influences of Vitamin D and B12 in Infectious Diseases and Microbes: A Technical Review

2021 ◽  
Vol 9 (2) ◽  
pp. 80-88
Author(s):  
Jase Grimm
Keyword(s):  
Vitamin D ◽  
Infectious Diseases ◽  
Vitamin B12 ◽  
Vitamin D Deficiency ◽  
Gut Microbiome ◽  
Processed Foods ◽  
E Coli ◽  
B12 Deficiency ◽  
B Vitamin ◽  
Butyrate Production

A diet rich in vitamin D. Bacteria, antibiotics, and metabolism Vitamin D deficiency viral microbiomes Gut Microbiome and Vitamin D. B vitamin deficiency results from malabsorption. SIF complex indirectly enhances B12 absorption. This complex gives the ileum vitamin B12. Anti-infective properties of B12 and D. B12 and D seem to slow Lachnospiraceae growth. P-cresol, butyrate, propionate Lachnospira is linked to low B12 and D levels. Debatable value. Processed foods do. B12 and D stop Blautia growth. IBD B12 deficiency IBD vitamin D Lactobacillus was infrequent, whereas E. coli was common. This present study revealed that IPA, an antioxidant, has been associated with diabetes and Alzheimer's. IPA beats melatonin. It doesn't appear to stop Alzheimer's or diabetes. Flavonoids and neuroprotective viruses D and B12 metabolism may involve Blautia. Deficiency of B12 and D in Crohn's. It reduced butyrate production. Inflammation, atherosclerosis, and immunological maturation may be cured by these nutrients.

scholarly journals The prevalence of low serum levels of Vitamin D, Vitamin B12, folate and ferritin in adolescents: Single center experience

2021 ◽  
Vol 104 (2) ◽  
pp. 003685042110076
Author(s):  
Nazmi Mutlu Karakaş
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Medical Records ◽  
Vitamin B12 Deficiency ◽  
Serum Levels ◽  
Folate Deficiency ◽  
Well Child Care ◽  
Single Center Experience ◽  
B12 Deficiency ◽  
Prevalence Of Anemia

Background: In this study, the aim was to evaluate the prevalence of vitamin D, vitamin B12, ferritin, and folate deficiencies in adolescence to clarify the need for early diagnosis and therapy. Methods: The medical records of adolescents between 10 and 18 years of age between 01 September 2018 and 28 February 2019 as healthy with non-specific complaints, or due to well-child care visits, were analyzed retrospectively. Results: A total of 1847/2507 (73.6%) adolescents were included in the study. The prevalence of vitamin D deficiency was 25.7% (n: 178/691). Vitamin B12 deficiency prevalence was 69.2% (n: 753/1088). The prevalence of anemia and ferritin deficiency was 4.8% and 13.26%. The prevalence of folate deficiency was 37.9% (n: 413/1088). VDD prevalence was statistically significantly higher in females than males (F/M:116/62). VB12D prevalence, the number and mean age of females with hemoglobin deficiency, and low ferritin levels was found to be statistically significantly higher in females than males. Conclusions: The prevalence of vitamin D, vitamin B12, folate deficiency and low ferritin levels was found to be high among adolescents. In particular, adolescents admitting with non-specific complaints and for control purposes in big cities must be considered to be at risk for the deficiency of these vitamins and low level of ferritin.

scholarly journals 0809 A Randomized Double-blind, Placebo Controlled Trial With Cross-over, To Assess The Efficacy Of Correcting Vitamin D Deficiency In Improving The Symptoms Of Restless Legs Syndrome (RLS)

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A307-A308
Author(s):  
J Wong ◽  
D Gupta ◽  
A Nadhim ◽  
S Bhat ◽  
P Polos
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Controlled Trial ◽  
Activity Count ◽  
Double Blind ◽  
Vitamin D Levels ◽  
Effect Of Treatment ◽  
B Vitamin

Abstract Introduction Recent studies have shown an association of low Vitamin D levels and severity of RLS symptoms. However, effect of treatment of Vit D deficiency on RLS symptoms was not reported, nor were other exacerbating factors for RLS such as iron deficiency or OSA addressed in prior studies, but have been addressed in our study. Methods This is an ongoing study at the JFKMC Sleep Clinic. Eligible Patients with RLS include those with vitamin D 25,hydroxy deficiency (<20 ng/ml), or insufficiency (<30 ng/ml). Such patients will be enrolled in the study after comorbid conditions like iron deficiency and OSA have been adequately corrected. Randomization of the patients will be done by the JFK pharmacy so the patient and provider are blinded to the substance. Substance A or B could be either Vitamin D3 Capsule 50,000 IU, or placebo. Each patient takes A for 6 weeks and then crosses over to B for 6 weeks. Weekly iRLS questionnaires will be collected. Actiwatch Device, to assess activity count per minute, will be worn on the ankle at night for one week time periods: at baseline, at end of 6 weeks of taking A and then at the end of 6 weeks of taking B. Vitamin D levels will also be assessed after each course of supplementation and correlated with subjective and objective findings. Results Between July 7, 2019 to current, 50 consecutive patients seen in sleep clinic with RLS were assessed for vitamin D levels. Ages ranged from 23-86 years. 27 patients were female (54%). Two patients met inclusion criteria and have started their 13-week study. Conclusion This study will help to establish the role of Vitamin D deficiency as a risk factor for RLS, independent of ferritin levels, and comorbid OSA, in affected individuals. This may help to discover a potentially treatable form of RLS. Support No financial support.

An update on the association of vitamin D deficiency with common infectious diseases

2015 ◽  
Vol 93 (5) ◽  
pp. 363-368 ◽  
Author(s):  
Richard R. Watkins ◽  
Tracy L. Lemonovich ◽  
Robert A. Salata
Keyword(s):  
Vitamin D ◽  
Infectious Diseases ◽  
Vitamin D Deficiency ◽  
Health Care Facilities ◽  
Future Research ◽  
Therapeutic Implications ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Recent Developments ◽  
Future Research Directions

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions.

scholarly journals Prevalence of Vitamin D and Vitamin B12 Deficiency in Patients reporting to the West Bank governmental hospitals in the period between January 2015 and December 2018

2021 ◽  
Vol 01 (1) ◽  
pp. 16-23
Author(s):  
Dina Bitar
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Vitamin D Deficiency ◽  
Elderly Women ◽  
West Bank ◽  
Vitamin B12 Deficiency ◽  
Risk Groups ◽  
The West ◽  
Cross Sectional ◽  
Vitamin D Levels

Vitamin D and vitamin B12 deficiencies are major public health problems; they may result from inappropriate low exposure to sunlight, autoimmune diseases or diminished intake. These two deficiencies have been extensively studied globally: causes, e"ects, treatment, as well as epidemiology. In Palestine the epidemiology of vitamin D and vitamin B12 deficiencies has not been addressed. This study was undertaken to determine the prevalence of vitamin D and vitamin B12 deficiencies in patients reporting to the West Bank (WB) governmental hospitals in the period between January 2015 and December 2018. It is a retrospective cross-sectional study for the data collected from medical records of patients tested for these deficiencies in 12 WB governmental hospitals for the three years period. Out of 30890 patients tested for vitamin D levels, 88% had insu!cient vitamin D levels (< 30 ng/ml), whereas out of 43532 patients tested for vitamin B12, 19% had insu!cient vitamin B12 levels (< 203 pg/ml). The percentage of patients with insu!cient vitamin D levels is alarming. The percentage of patients with insu!cient vitamin B12 levels falls within ranges reported by other studies in various countries. In conclusion, this study revealed an alarmingly high percentage (88%) of vitamin D deficiency below the reference su!ciency level among patients suspected to have such a deficiency. Around one fifth of the patients tested for vitamin B12 had insu!cient levels. Because testing for vitamin D is costly, we suggest, that medical suspicion of vitamin D deficiency would be adequate to initiate treatment to alleviate the expense, especially in high-risk groups such as elderly women. Future studies have to address major risk factors contributing to these deficiencies that are specific to our community.

Nutritional Deficiencies and Toxicities

2017 ◽  
Author(s):  
Karl E. Misulis ◽  
E. Lee Murray
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Copper Deficiency ◽  
Protein Energy Malnutrition ◽  
Nutritional Deficiencies ◽  
Wernicke Encephalopathy ◽  
Diagnosis And Management ◽  
Protein Energy ◽  
Korsakoff Syndrome ◽  
B12 Deficiency

Nutritional disorders are often encountered in hospital neurology practice, especially deficiencies of vitamins B1 and B12. Medical conditions can predispose to nutritional disorders. This chapter discusses the presentation, diagnosis, and management of B12 deficiency, B1 deficiency, protein-energy malnutrition, folate deficiency especially in the context of pregnancy, B6 deficiency, B6 toxicity, copper deficiency, and vitamin D deficiency. Wernicke encephalopathy and Korsakoff syndrome are also discussed.

scholarly journals Association of Gut Microbiome and Vitamin D Deficiency in Knee Osteoarthritis Patients: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1272
Author(s):  
Boopalan Ramasamy ◽  
Fabien Magne ◽  
Sujit Kumar Tripathy ◽  
Giriprasad Venugopal ◽  
Diptasree Mukherjee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Knee Osteoarthritis ◽  
Vitamin D Deficiency ◽  
Gut Microbiome ◽  
Bacterial Species ◽  
Serum Vitamin ◽  
Core Microbiome ◽  
Serum Vitamin D ◽  
Significant Difference

Background: Few preclinical studies have shown that Knee osteoarthritis (KOA) is linked to gut microbiome dysbiosis and chronic inflammation. This pilot study was designed to look at the gut microbiome composition in KOA patients and normal individuals with or without vitamin D deficiency (VDD, serum vitamin D <30 ng/mL). Methods: This pilot study was conducted prospectively in 24 participants. The faecal samples of all the participants were taken for DNA extraction. The V3-V4 region of 16s rRNA was amplified, and the library was prepared and sequenced on the Illumina Miseq platform. Results: The mean (±SD) age was 45.5 (±10.2) years with no defined comorbidities. Of 447 total Operational Taxonomic Units (OTUs), a differential abundance of 16 nominally significant OTUs between the groups was observed. Linear discriminate analysis (LEfSe) revealed a significant difference in bacteria among the study groups. Pseudobutyrivibrio and Odoribacter were specific for VDD, while Parabacteroides, Butyricimonas and Gordonibacter were abundant in the KOA_VDD group, and Peptococcus, Intestimonas, Delftia and Oribacterium were abundant in the KOA group. About 80% of bacterial species were common among different groups and hence labelled as core bacterial species. However, the core microbiome of KOA and VDD groups were not seen in the KOA_VDD group, suggesting that these bacterial groups were affected by the interaction of the KOA and VDD factors. Conclusion: Parabacteroides, Butyricimonas, Pseudobutyrivibrio, Odoribacter and Gordonibacter are the predominant bacteria in vitamin D deficient patients with or without KOA. Together these results indicate an association between the gut microbiome, vitamin D and knee osteoarthritis.

Interrelationships between the incidence of infectious diseases and vitamin D deficiency: the current state of the problem

2018 ◽  
Vol 16 (3) ◽  
pp. 69-78 ◽  
Author(s):  
I.N. Zakharova ◽  
◽  
L.Ya. Klimov ◽  
A.N. Kasyanova ◽  
V.A. Kuryaninova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Infectious Diseases ◽  
Vitamin D Deficiency ◽  
Current State
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