Abnormal Findings Diagnostic of Anogenital Trauma in Prepubertal Children

2021 ◽  
pp. 1047-1076
Author(s):  
Michelle Clayton ◽  
Amber L. Shipman
Keyword(s):  
Prepubertal Children

Radioiodine Uptake Values in Euthyroid, Non-Goitrous, Prepubertal Children in Greece

1973 ◽  
Vol 12 (01) ◽  
pp. 26-34
Author(s):  
D. Liakakos ◽  
D. Ikkos ◽  
P. Vlachos ◽  
S. Gonticas ◽  
P. Matsioulas ◽  
...  
Keyword(s):  
Radioiodine Uptake ◽  
Prepubertal Children

La fixation thyroïdienne du 131I a été mesurée en 50 enfants non-goitreux agés de 2 à 12 ans (17 masculins, 33 féminins). Les valeurs de fixation des enfants grèques (l’erreur standard ± pour les deux sexes était 38,8 ± 1,81; 59,1 ± 2,17; 60,2 ± 2,16 à 3, 24 et 48 heures) sont les plus élevées rapportées jusqu’à maintenant das la litérature donnant preuve à la pénurie de l’iode dans notre pays. Une autre manifestation de la pénurie de l’iode était l’observation, que dans 41% des enfants prépubertaires les valeurs PB 131I à 48 heures étaient plus élevées que la limite supérieure normale de 0,4% par litre.Les enfants féminines montraient des valeurs de fixation significativement (P < 0,05) plus élevées que les masculins avec un taux de différence des valeurs moyennes de 1,34; 1,19; et 1,15 à 3, 24 et 48 heures.

Brown adipose tissue in prepubertal children: associations with sex, birthweight, and metabolic profile

2019 ◽  
Author(s):  
Malpique R ◽  
Gallego-Escuredo JM ◽  
Sebastiani G ◽  
Villarroya J ◽  
Lopez-Bermejo A ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Metabolic Profile ◽  
Prepubertal Children ◽  
Brown Adipose

Steroid Rosacea in Prepubertal Children

2000 ◽  
Vol 4 (1) ◽  
pp. 7-7
Author(s):  
D. P. Krowchuck
Keyword(s):  
Prepubertal Children

1249-P: Type 2 Diabetes in Prepubertal Children under 10 Years Old

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1249-P
Author(s):  
MARCELA ASTUDILLO ◽  
AHMAD K. REFAEY ◽  
MUSTAFA TOSUR ◽  
ALEJANDRO F. SILLER ◽  
SIRIPOOM MCKAY ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prepubertal Children ◽  
P Type

Elevated circulating endothelial microparticles (EMPs) in prepubertal children born preterm

2021 ◽  
Author(s):  
Panagiota Markopoulou ◽  
Eleni Papanikolaou ◽  
Sofia Loukopoulou ◽  
Paraskevi Galina ◽  
Ioannis Papassotiriou ◽  
...  
Keyword(s):  
Endothelial Microparticles ◽  
Prepubertal Children

Role of urinary NGAL and KIM-1 as biomarkers of early kidney injury in obese prepubertal children

2020 ◽  
Vol 33 (9) ◽  
pp. 1183-1189 ◽  
Author(s):  
Nella Polidori ◽  
Cosimo Giannini ◽  
Roberta Salvatore ◽  
Piernicola Pelliccia ◽  
Adriana Parisi ◽  
...  
Keyword(s):  
Cystatin C ◽  
Kidney Injury ◽  
Normal Weight ◽  
Model Assessment ◽  
Urinary Ngal ◽  
Obese Children ◽  
Prepubertal Children ◽  
Ultrasound Evaluation ◽  
Kidney Length ◽  
Obese Subjects

AbstractObjectivesChildhood obesity is an important cause of end-stage renal disease. To date, available markers do not characterize kidney changes, especially in the early stages. kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are already detected before the onset of proteinuria or alterations of glomerular filtration rate and thus might represent biomarkers that directly reflect kidney injury.MethodsWe characterize kidney injury in a group of 40 obese-prepubertal children compared to 29-healthy age- and gender matched-peers. Anthropometric measurements and body composition were determined. Fasting blood samples were collected for measurement of insulin, glucose, lipid profile, transaminases, cystatin C and creatinine. Urine samples were collected to assess urinary NGAL, KIM-1 and urinary isoprostanes. Kidney length was measured with ultrasound evaluation. Differences between the two groups were evaluated by Mann–Whitney U test, and Spearman correlation analysis was used to explore relationship between variables.ResultsTriglycerides, alanine transaminase (ALT), glucose, insulin, homeostasis model assessment insulin resistance, triglycerides/high-density lipoprotein (HDL)-cholesterol ratio and cystatin C values were significantly higher in obese children than normal weight peers. Creatinine values were normal and similar between the two groups, while isoprostanes were higher in obese. Obese children had larger kidney sizes, indicating organ hypertrophy. NGAL and KIM-1 were increased in obese children compared to controls. A significant association between NGAL and KIM-1 with adiposity indices, insulin status and markers of oxidative stress postulated a possible effect of obesity in inducing kidney abnormalities. KIM-1 and NGAL are directly related respectively to cystatin C and isoprostanes, supporting the ability of these biomarkers in reflecting early kidney damages in obese subjects.ConclusionsThese findings suggest that obese subjects exhibit a certain degree of renal damage before kidney function loss.

Is overweight/obesity a risk factor for atopic allergic disease in prepubertal children? A case–control study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aysel Vehapoglu ◽  
Zeynep Ebru Cakın ◽  
Feyza Ustabas Kahraman ◽  
Mustafa Atilla Nursoy ◽  
Ali Toprak
Keyword(s):  
Body Weight ◽  
Allergic Disease ◽  
Weight Status ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
University Hospital ◽  
Healthy Children ◽  
Prepubertal Children ◽  
Body Weight Status ◽  
Increased Risk

Abstract Objectives It is unclear whether body weight status (underweight/normal weight/overweight/obese) is associated with allergic disease. Our objective was to investigate the relationship between body weight status (body mass index; BMI) and atopic allergic disease in prepubertal children, and to compare children with atopic allergic diseases with non atopic healthy children. Methods A prospective cross sectional study of 707 prepubertal children aged 3–10 years was performed; the participants were 278 atopic children with physician-diagnosed allergic disease (allergic rhinitis and asthma) (serum total IgE level >100 kU/l and eosinophilia >4%, or positivity to at least one allergen in skin test) and 429 non atopic healthy age- and sex-matched controls. Data were collected between December 2019 and November 2020 at the Pediatric General and Pediatric Allergy Outpatient Clinics of Bezmialem Vakıf University Hospital. Results Underweight was observed in 11.6% of all participants (10.8% of atopic children, 12.2% of healthy controls), and obesity in 14.9% of all participants (18.0% of atopic children, 12.8% of controls). Obese (OR 1.71; 95% CI: 1.08–2.71, p=0.021), and overweight status (OR 1.62; 95% CI: 1.06–2.50, p=0.026) were associated with an increased risk of atopic allergic disease compared to normal weight in pre-pubertal children. This association did not differ by gender. There was no relationship between underweight status and atopic allergic disease (OR 1.03; 95% CI: 0.63–1.68, p=0.894). Conclusions Overweight and obesity were associated with an increased risk of atopic allergic disease compared to normal weight among middle-income and high-income pre pubertal children living in Istanbul.

scholarly journals The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

2021 ◽  
Vol 18 (10) ◽  
pp. 5365
Author(s):  
Annie M. Constable ◽  
Josie E. Porter ◽  
Danielle Benger ◽  
Dimitris Vlachopoulos ◽  
Alan R. Barker ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vigorous Physical Activity ◽  
Normal Weight ◽  
Cross Sectional ◽  
Prepubertal Children ◽  
Total Body ◽  
The Relationship

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

Association of sleep characteristics with adiposity markers in children

2020 ◽  
Vol 33 (7) ◽  
pp. 845-852
Author(s):  
Theresa Herttrich ◽  
Johann Daxer ◽  
Andreas Hiemisch ◽  
Jens Kluge ◽  
Andreas Merkenschlager ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Sleep Diary ◽  
Apnea Hypopnea Index ◽  
Prepubertal Children ◽  
Arousal Index ◽  
Obstructive Sleep ◽  
Obesity In Children

AbstractBackgroundAccumulating evidence suggests a relationship between sleep alterations and overweight/obesity in children. Our aim was to investigate the association of sleep measures other than obstructive sleep apnea or sleep duration with overweight/obesity and metabolic function in children.MethodsWe conducted a prospective cohort study in school- aged children (aged 5 to 8 years, prepubertal, and 12 to 15 years, pubertal) with overweight/obesity and normal-weight children. All children underwent a standardized in-laboratory polysomnography followed by a fasting blood assessment for glucose and metabolic testing. Subjective sleep measures were investigated by a 7-day sleep diary and questionnaire. We analyzed prepubertal and pubertal groups separately using logistic regression and partial correlation analyses.ResultsA total of 151 participants were analyzed. Overweight/obese children had significantly higher odds for arousal index (prepubertal children: 1.28, Confidence interval (CI): 1.06, 1.67; pubertal children: 1.65, CI: 1.19, 2.29) than normal-weight children, independent of age and gender. In prepubertal children, arousal-index was positively associated with C-peptide (r=0.30, p=0.01), whereas Minimum O2 saturation was negatively associated with triglycerides (r=−0.34, p=0.005), adjusting for age and sex. However, associations were attenuated by further adjustment for body mass index standard deviation scores (BMI-SDS). In pubertal children, higher level of apnea-hypopnea-index and pCO2 predicted increased lipoprotein (a) levels (r=0.35, p=0.03 and r=0.40, p=0.01, respectively), independent of age, sex, and BMI-SDS. A negative association was found between pCO2 and high-density lipoprotein (HDL)-cholesterol (r=−0.40, p=0.01).ConclusionsOverall, we report that sleep quality as measured by arousal index may be compromised by overweight and obesity in children and warrants attention in future intervention programs.

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