A Multiobjective Procedure for Project Formulation — Design of a Chemical Installation

1984 ◽  
pp. 248-259 ◽  
Author(s):  
H. Górecki ◽  
J. Kopytowski ◽  
T. Ryś ◽  
M. Żebrowski
Keyword(s):  
Formulation Design ◽  
Project Formulation

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

Benzocaine loaded solid lipid nanoparticles: Formulation design, in vitro and in vivo evaluation of local anesthetic effect

2015 ◽  
Vol 12 (6) ◽  
pp. 680-692 ◽  
Author(s):  
Mona Basha ◽  
Sameh Abd El-Alim ◽  
Ahmed Kassem ◽  
Sally El Awdan ◽  
Gamal Awad
Keyword(s):  
Local Anesthetic ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Formulation Design ◽  
Solid Lipid ◽  
Anesthetic Effect

scholarly journals Self-buffering capacity of a human sulfatase for central nervous system delivery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yi Wen ◽  
Nazila Salamat-Miller ◽  
Keethkumar Jain ◽  
Katherine Taylor
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Buffering Capacity ◽  
The Self ◽  
High Concentration ◽  
Formulation Design ◽  
The Central Nervous System ◽  
Therapeutic Enzymes ◽  
Intrathecal Space

AbstractDirect delivery of therapeutic enzymes to the Central Nervous System requires stringent formulation design. Not only should the formulation design consider the delicate balance of existing ions, proteins, and osmolality in the cerebrospinal fluid, it must also provide long term efficacy and stability for the enzyme. One fundamental approach to this predicament is designing formulations with no buffering species. In this study, we report a high concentration, saline-based formulation for a human sulfatase for its delivery into the intrathecal space. A high concentration formulation (≤ 40 mg/mL) was developed through a series of systematic studies that demonstrated the feasibility of a self-buffered formulation for this molecule. The self-buffering capacity phenomenon was found to be a product of both the protein itself and potentially the residual phosphates associated with the protein. To date, the self-buffered formulation for this molecule has been stable for up to 4 years when stored at 5 ± 3 °C, with no changes either in the pH values or other quality attributes of the molecule. The high concentration self-buffered protein formulation was also observed to be stable when exposed to multiple freeze–thaw cycles and was robust during in-use and agitation studies.

Resveratrol loaded self-nanoemulsifying drug delivery system (SNEDDS) for pancreatic cancer: Formulation design, optimization and in vitro evaluation

2021 ◽  
pp. 102555
Author(s):  
Shadab Md ◽  
Nabil A. Alhakamy ◽  
Hibah M. Aldawsari ◽  
Javed Ahmad ◽  
Waleed S. Alharbi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Design Optimization ◽  
Drug Delivery System ◽  
Delivery System ◽  
Formulation Design ◽  
In Vitro Evaluation

Formulation design and pharmaceutical development of a novel controlled release form of azithromycin for single-dose therapy

2009 ◽  
Vol 35 (12) ◽  
pp. 1522-1529 ◽  
Author(s):  
Julian B. Lo ◽  
Leah E. Appel ◽  
Scott M. Herbig ◽  
Scott B. McCray ◽  
Avinash G. Thombre
Keyword(s):  
Single Dose ◽  
Controlled Release ◽  
Formulation Design ◽  
Pharmaceutical Development ◽  
Dose Therapy ◽  
Single Dose Therapy ◽  
Release Form

Computational modeling for formulation design

2019 ◽  
Vol 24 (3) ◽  
pp. 781-788 ◽  
Author(s):  
Chetan Hasmukh Mehta ◽  
Reema Narayan ◽  
Usha Y. Nayak
Keyword(s):  
Computational Modeling ◽  
Formulation Design
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