The metabolic syndrome and signal transduction of gene expression

1991 ◽  
pp. 65-81
Author(s):  
H. Rupp
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Signal Transduction ◽  
The Metabolic Syndrome

Integrating Genetic and Gene Expression Data to Study the Metabolic Syndrome and Diabetes in Mice

2005 ◽  
Vol 12 (6) ◽  
pp. 503-511 ◽  
Author(s):  
Thomas A Drake ◽  
Eric E Schadt ◽  
Richard C Davis ◽  
Aldons J Lusis
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Gene Expression Data ◽  
Expression Data ◽  
The Metabolic Syndrome ◽  
Diabetes In Mice

scholarly journals Improvement of Cardiac Fibrosis Biomarkers through Inflammation Inhibition by Green Tea and Decaffeinated Light Roasted Green Coffee Extract Combination Administration in Metabolic Syndrome Rat Model

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1013
Author(s):  
Mifetika Lukitasari ◽  
Mohammad Saifur Rohman ◽  
Dwi Adi Nugroho ◽  
Nila Aisyah Wahyuni ◽  
Mukhamad Nur Kholis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Green Tea ◽  
Rat Model ◽  
Cardiac Fibrosis ◽  
Significant Risk ◽  
Green Coffee ◽  
The Metabolic Syndrome ◽  
Tnf Α ◽  
Tgf Β1

Background: Metabolic syndrome is a significant risk factor for cardiovascular diseases. Green tea and green coffee extracts, antioxidant and anti-inflammatory agents may participate in metabolic syndrome-induced cardiac fibrosis alleviation. However, the effect of combination of those extracts still needs exploration. Therefore, this study investigated the effect of green tea and decaffeinated light roasted green coffee extracts and their combination in metabolic syndrome-induced cardiac fibrosis rats. Methods: Metabolic syndrome rat model was i1nduced through high-fat high sucrose diets feeding for 8 weeks and injection of low dose streptozotocin at the 2nd week. The metabolic syndrome rats were divided into 4 experimental groups metabolic syndrome rats (MS); metabolic syndrome rats treated with 300 mg/ kg b.w green tea extract (GT); metabolic syndrome rats treated with 200 mg/ kg b.w decaffeinated light roasted green coffee extract (GC); metabolic syndrome rats treated with the combination of the two extracts (CE); and a normal control (NC) group was added. Angiotensin 2 level was analyzed by ELISA method. Gene expression of NF-κB, TNF-α, IL-6, Tgf-β1, Rac-1, and α-sma were analyzed by touchdown polymerase chain reaction methods. Results: Metabolic syndrome rats treated with green tea and decaffeinated light roasted green coffee significantly decreased angiotensin-2 serum level and cardiac inflammation and fibrosis gene expression level (NF-κB, TNF-α, IL-6, Tgf-β1, Rac-1, and α-sma). More significant alleviation was observed in the combination group. Conclusion: This study suggested that combination of green tea and decaffeinated light roasted green coffee extracts showed better improvement in metabolic syndrome-induced cardiac fibrosis rat model compared to that of single extract administration through inflammation inhibition

Pre- and early postnatal nongenetic determinants of type 2 diabetes

2002 ◽  
Vol 4 (24) ◽  
pp. 1-14 ◽  
Author(s):  
Susan E. Ozanne ◽  
C. Nick Hales
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Hormone Receptors ◽  
Early Growth ◽  
Growth Restriction ◽  
Future Research ◽  
Thrifty Phenotype ◽  
The Metabolic Syndrome

Epidemiological studies have revealed strong and internationally reproducible links between early growth restriction and subsequent risk of developing type 2 diabetes and the metabolic syndrome (glucose intolerance, hypertension and hypertriglyceridaemia). This effect can exist independently of genetic factors. There is also direct evidence that poor maternal nutrition and maternal smoking cause both a reduction in birthweight and subsequent loss of glucose tolerance. High rates of growth in childhood may add to these effects. The ‘thrifty phenotype’ hypothesis attempts to explain these associations in terms of an altered programming of growth and metabolism that aids survival both pre- and postnatally. Type 2 diabetes is envisaged as a consequence of a clash of this programming with adult obesity. Tests of this hypothesis in animal models have shown that both the metabolic syndrome and type 2 diabetes can result from early growth restriction in rats consequent upon rat dams being fed a reduced protein, isocaloric diet (in which the protein is replaced by an equal quantity of nonprotein energy). A variety of other models of early growth restriction in rats lead to a similar phenotype. Several structural and gene expression changes have been shown in many tissues, including pancreas, liver, kidney, muscle and adipose tissue. Changes in gene expression include those concerned with hormone receptors, signalling and glycolytic enzymes. Many important questions remain for future research.

scholarly journals Adiponectin Gene Expression and Plasma Values in Obese Women during Very-Low-Calorie Diet. Relationship with Cardiovascular Risk Factors and Insulin Resistance

2004 ◽  
Vol 89 (2) ◽  
pp. 756-760 ◽  
Author(s):  
Marta Garaulet ◽  
Nathalie Viguerie ◽  
Stefan Porubsky ◽  
Eva Klimcakova ◽  
Karine Clement ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Obese Women ◽  
Adiponectin Gene ◽  
Very Low Calorie Diet ◽  
Plasma Adiponectin ◽  
The Metabolic Syndrome ◽  
Low Calorie Diet ◽  
Calorie Diet

Adiponectin, a newly discovered adipose-tissue-specific protein, is thought to be involved in the regulation of insulin action. The aim of the present study was to determine whether adiponectin contributes to the improvement in insulin sensitivity during very-low-calorie diet (VLCD). Biopsies of sc abdominal adipose tissue and blood sampling for analysis of plasma adiponectin and related hormones and metabolites were performed before and at the end of a 4-wk VLCD in 33 nonmorbidly obese women (body mass index, 34.4 ± 4.1 kg/m2). VLCD produced a decrease in weight (7.1 ± 0.4 kg) and in insulin and leptin levels and led to an improvement in insulin sensitivity. Adiponectin gene expression and plasma levels were not modified during calorie restriction. Before VLCD, we found negative correlations between plasma adiponectin and variables related to the metabolic syndrome. Adiponectin mRNA levels showed a negative correlation with lipoprotein a plasma values. The correlations observed before VLCD were not found after VLCD. The data suggest that adiponectin is related to the protection against the metabolic syndrome but is not involved in the regulation of VLCD-induced improvement of insulin sensitivity.

scholarly journals Whole Blood Gene Expression Profiles in Insulin Resistant Latinos with the Metabolic Syndrome

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e84002 ◽  
Author(s):  
Samantha E. Tangen ◽  
Darwin Tsinajinnie ◽  
Martha Nuñez ◽  
Gabriel Q. Shaibi ◽  
Lawrence J. Mandarino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Whole Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression ◽  
Insulin Resistant ◽  
The Metabolic Syndrome

scholarly journals Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2342
Author(s):  
Tomohisa Takagi ◽  
Ryotaro Hayashi ◽  
Yuji Nakai ◽  
Shinji Okada ◽  
Rumiko Miyashita ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Visceral Fat ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
High Body Mass Index ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Japanese Men ◽  
The Metabolic Syndrome

Metabolic syndrome, whose main diagnostic component is obesity, is a risk factor for lifestyle-related diseases, type 2 diabetes, and cardiovascular disease. Diet is known to affect the prevalence of metabolic syndrome. However, the effect of diet on metabolic syndrome in Japanese subjects has not been thoroughly explored. In the present study, we investigated the effect of carotenoid-rich vegetables, particularly lycopene- and lutein-rich vegetables, on the metabolic syndrome in obese Japanese men. We conducted an 8-week long randomized, double-blinded, controlled clinical trial in which, 28 middle-aged (40 ≤ age < 65) Japanese men with high body mass index (BMI ≥ 25) were randomized into four dietary groups: high lycopene + high lutein (HLyHLu), high lycopene + low lutein (HLyLLu), low lycopene + high lutein (LLyHLu), and low lycopene + low lutein (LLyLLu). Our results showed that daily beverage-intake increased the plasma levels of carotenoids without adverse effects, and the visceral fat level was significantly decreased in all the groups. The waist circumference was significantly decreased only in the HLyLLu group, whereas the CoQ10 oxidation rate was decreased in all the groups. The gene expression profiles of whole blood samples before and after ingestion differed only in the LLyLLu group, indicating the effect of carotenoids on gene expression profile. In conclusion, our results suggest that dietary uptake of carotenoid-rich vegetables increases their concentration in blood and reduces the intra-abdominal visceral fat.

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