Bile Acid as Therapeutic Agents

2017 ◽  
pp. 61-90 ◽  
Author(s):  
Yoshihide Yamanashi ◽  
Tappei Takada ◽  
Hiroshi Suzuki
Keyword(s):  
Bile Acid ◽  
Therapeutic Agents

scholarly journals Bile Acid Conjugates with Anticancer Activity: Most Recent Research

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 25
Author(s):  
Maria Luisa Navacchia ◽  
Elena Marchesi ◽  
Daniela Perrone
Keyword(s):  
Bile Acid ◽  
Cancer Therapy ◽  
Anticancer Activity ◽  
Bile Acids ◽  
Treatment Modality ◽  
Biological Properties ◽  
Therapeutic Agents ◽  
Bioactive Molecules ◽  
Hybrid Functional ◽  
Hybrid Molecules

The advantages of a treatment modality that combines two or more therapeutic agents in cancer therapy encourages the study of hybrid functional compounds for pharmacological applications. In light of this, we reviewed recent works on hybrid molecules based on bile acids. Due to their biological properties, as well as their different chemical/biochemical reactive moieties, bile acids can be considered very interesting starting molecules for conjugation with natural or synthetic bioactive molecules.

Bile acids and bile acid derivatives: use in drug delivery systems and as therapeutic agents

2016 ◽  
Vol 13 (8) ◽  
pp. 1133-1148 ◽  
Author(s):  
Célia Faustino ◽  
Cláudia Serafim ◽  
Patrícia Rijo ◽  
Catarina Pinto Reis
Keyword(s):  
Drug Delivery ◽  
Bile Acid ◽  
Bile Acids ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Bile Acid Derivatives

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets

2020 ◽  
Vol 134 (12) ◽  
pp. 1403-1432 ◽  
Author(s):  
Manal Muin Fardoun ◽  
Dina Maaliki ◽  
Nabil Halabi ◽  
Rabah Iratni ◽  
Alessandra Bitto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fruits And Vegetables ◽  
Metabolic Diseases ◽  
Therapeutic Agents ◽  
Adipose Tissue Inflammation ◽  
Cellular Mechanisms ◽  
Tissue Inflammation ◽  
Cholesterol Levels ◽  
Naturally Occurring ◽  
Pro Inflammatory Cytokines

Abstract Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.

Bile acid stimulation of small bile duct proliferation requires de novo expression of the apical bile acid transporter (ABAT)

2001 ◽  
Vol 120 (5) ◽  
pp. A1-A1
Author(s):  
G ALPINI ◽  
S GLASER ◽  
J PHINIZY ◽  
N KANNO ◽  
H FRANCIS ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
De Novo ◽  
Bile Duct Proliferation ◽  
Bile Acid Transporter ◽  
Small Bile Duct ◽  
Acid Transporter ◽  
Stimulation Of

Non-conjugated bile acid induces mitochondrial damage in pancreatic ductal epithelial cell

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
J Maléth ◽  
Z Rakonczay ◽  
V Venglovecz ◽  
Z Rázga ◽  
L Tiszlavicz ◽  
...  
Keyword(s):  
Bile Acid ◽  
Epithelial Cell ◽  
Mitochondrial Damage ◽  
Ductal Epithelial Cell

Higher frequency of peripheral CD3CXCR3 and CD4CXCR3 positive blood cells in HCV patients in context of bile acid retention

2014 ◽  
Vol 52 (01) ◽  
Author(s):  
M Rau ◽  
J Schmitt ◽  
T Kudlich ◽  
JJG Marin ◽  
M Rodríguez Romero ◽  
...  
Keyword(s):  
Bile Acid ◽  
Blood Cells

Differential regulation of G-protein coupled bile acid receptor (Gpbar-1) by Sp1/KLF5 family transcription factors

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
C Chintalapati ◽  
C Wöhler ◽  
C Ehlting ◽  
J Bode ◽  
D Häussinger ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Bile Acid ◽  
G Protein ◽  
Differential Regulation ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
G Protein Coupled
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