The Battle: Quorum-Sensing Inhibitors Versus Evolution of Bacterial Resistance

2014 ◽  
pp. 385-391 ◽  
Author(s):  
Vipin C. Kalia ◽  
Prasun Kumar
Keyword(s):  
Quorum Sensing ◽  
Bacterial Resistance ◽  
Quorum Sensing Inhibitors

scholarly journals NATURAL ANTIMICROBIALS IN THE PIPELINE AND POSSIBLE SYNERGISM WITH ANTIBIOTICS TO OVERCOME MICROBIAL RESISTANCE

2019 ◽  
pp. 15-21
Author(s):  
EMTENAN M HANAFI ◽  
ENAS N DANIAL
Keyword(s):  
Quorum Sensing ◽  
Bioactive Compounds ◽  
Biofilm Formation ◽  
Bacterial Resistance ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Quorum Sensing Inhibitors ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

The unresponsive use of antibiotics led to the appearance of multiple drug-resistant bacteria strains. Studying the mechanism by which bacteria can resist antibiotics, the so called quorum sensing and biofilm formation, enabled the researchers to find bioactive compounds, derived from eukaryotes and prokaryotes. The disrupt of this mechanism is called quorum sensing inhibitors or quorum quenchers. This article provides an overview on the current research done on such bioactive compounds, the possible use of them as antibiotic alternatives, what are the advantage and disadvantages, the source from which it has been extracted, and how it may succeed to overcome bacterial resistance. The recommendation of researchers is to use some of these natural antimicrobial compounds combined to lower doses of antibiotics for treatment, the fastest way to limit the adverse effects of the exploitation of antibiotics and to avoid bacterial resistance.

scholarly journals Polyphenols from Salix tetrasperma Impair Virulence and Inhibit Quorum Sensing of Pseudomonas aeruginosa

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1341 ◽  
Author(s):  
Islam Mostafa ◽  
Hisham A. Abbas ◽  
Mohamed L. Ashour ◽  
Abdelaziz Yasri ◽  
Assem M. El-Shazly ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Secondary Metabolites ◽  
Bacterial Resistance ◽  
Stem Bark ◽  
Dependent Manner ◽  
Active Components ◽  
Quorum Sensing Inhibitors ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacterial resistance represents one of the emerging obstacles in plants, animals, and humans that impairs treatment with antibacterial agents. Targeting of the bacterial quorum sensing system is one of the strategies to overcome this problem. Recently, research has been focused on natural and food components which can function as quorum sensing inhibitors. In this study, a methanol extract from Salix tetrasperma stem bark was phytochemically profiled by LC-MS analysis. This resulted in the identification of 38 secondary metabolites with (epi)catechin-(epi)catechin, epicatechin, tremulacin, salicortin, and trichocarposide as the major constituents. The extracts of both stem bark and the previously profiled flower of S. tetrasperma were tested for anti-quorum sensing activity in a common and widely distributed pathogen Pseudomonas aeruginosa. The natural products inhibited swimming and swarming motilities, as well as proteolytic and hemolytic activities in a dose-dependent manner. Molecular docking of the constituents from both extracts against the quorum sensing controlling systems Lasl/LasR, rhll/rhlR, and PQS/MvfR showed that epicatechin, (epi)catechin-(epi)catechin, p-hydroxy benzoyl galloyl glucose, p-hydroxy benzoyl protocatechuic acid glucose, and caffeoylmalic acid could be the main active components. This study supports the importance of secondary metabolites, especially polyphenols, as quorum sensing inhibitors.

Quorum Sensing – A Stratagem for Conquering Multi-Drug Resistant Pathogens

2020 ◽  
Vol 26 ◽  
Author(s):  
Madison Tonkin ◽  
Shama Khan ◽  
Mohmmad Younus Wani ◽  
Aijaz Ahmad
Keyword(s):  
Drug Resistance ◽  
Quorum Sensing ◽  
Virulence Factors ◽  
Biofilm Formation ◽  
Cell Communication ◽  
Natural Compounds ◽  
Quorum Sensing Inhibitors ◽  
Communication Technique ◽  
Multicellular Organisms ◽  
Chemical Strategies

: Quorum sensing is defined as cell to cell communication between microorganisms, which enables microorganisms to behave as multicellular organisms. Quorum sensing enables many collaborative benefits such as synchronisation of virulence factors and biofilm formation. Both quorum sensing as well as biofilm formation encourage the development of drug resistance in microorganisms. Biofilm formation and quorum sensing are causally linked to each other and play role in the pathogenesis of microorganisms. With the increasing drug resistance against the available antibiotics and antifungal medications, scientists are combining different options to develop new strategies. Such strategies rely on the inhibition of the communication and virulence factors rather than on killing or inhibiting the growth of the microorganisms. This review encompasses the communication technique used by microorganisms, how microorganism resistance is linked to quorum sensing and various chemical strategies to combat quorum sensing and thereby drug resistance. Several compounds have been identified as quorum sensing inhibitors and are known to be effective in reducing resistance as they do not kill the pathogens but rather disrupt their communication. Natural compounds have been identified as anti-quorum sensing agents. However, natural compounds present several related disadvantages. Therefore, the need for the development of synthetic or semi-synthetic compounds has arisen. This review argues that anti-quorum sensing compounds are effective in disrupting quorum sensing and could therefore be effective in reducing microorganism drug resistance.

Screening and Preservation Application of Quorum Sensing Inhibitors of Pseudomonas Fluorescens and Shewanella Baltica in Seafood Products

LWT ◽  
2021 ◽  
pp. 111749
Author(s):  
Yanbo Wang ◽  
Yongzheng Wang ◽  
Jian Chen ◽  
Shigenobu Koseki ◽  
Qing Yang ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Pseudomonas Fluorescens ◽  
Quorum Sensing Inhibitors ◽  
Seafood Products ◽  
Shewanella Baltica

scholarly journals SELECTED PHYTOCHEMICAL BIOACTIVE COMPOUNDS AS QUORUM SENSING INHIBITORS

2012 ◽  
pp. 93-97 ◽  
Author(s):  
P. Truchado ◽  
F.A. Tomás-Barberán ◽  
A. Allende ◽  
A. Ponce
Keyword(s):  
Quorum Sensing ◽  
Bioactive Compounds ◽  
Quorum Sensing Inhibitors
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