Plant-Derived Extracts and Compounds: An Alternative Therapy Against Breast Cancer

AbstractDrug repositioning refers to new uses for existing drugs outside the scope of the original medical indications. This approach fastens the process of drug development allowing finding effective drugs with reduced side effects and lower costs. Colorectal cancer (CRC) is often diagnosed at advanced stages, when the probability of chemotherapy resistance is higher. Triple negative breast cancer (TNBC) is the most aggressive type of breast cancer, highly metastatic and difficult to treat. For both tumor types, available treatments are generally associated to severe side effects. In our work, we explored the effect of combining metformin and propranolol, two repositioned drugs, in both tumor types. We demonstrate that treatment affects viability, epithelial-mesenchymal transition and migratory potential of CRC cells as we described before for TNBC. We show that combined treatment affects different steps leading to metastasis in TNBC. Moreover, combined treatment is also effective preventing the development of 5-FU resistant CRC. Our data suggest that combination of metformin and propranolol could be useful as a putative adjuvant treatment for both TNBC and CRC and an alternative for chemo-resistant CRC, providing a low-cost alternative therapy without associated toxicity.

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Effect of Integrated Ayurveda and Yoga Therapy (IAYT) on osteoporosis detected in breast cancer patient on remission- A single case study

Integrative Medicine Case Reports ◽

10.38205/imcr.010223 ◽

2020 ◽

Vol 1 (2) ◽

pp. 23

Author(s):

Satyam Tripathi ◽

Megha Panchal ◽

Nooraini Binti Aliyas

Keyword(s):

Breast Cancer ◽

Bone Density ◽

Ductal Carcinoma ◽

Single Case ◽

Alternative Therapy ◽

Breast Cancer Patients ◽

Yoga Therapy ◽

Holistic Treatment ◽

Treatment Medication

This is a case study for invasive ductal carcinoma diagnosed in a patient aged 60 years in 2015. She went through chemotherapy and radiotherapy and was on remission in 2016. Bone density degeneration was the side effect from the breast cancer treatment. After trying the conventional treatment, she was not satisfied, she came to Union Yoga Ayurveda (UYA), Singapore. She came to clinic looking for alternative therapy to help her increase her bone density, cope up with weakness and overall mental and physical wellbeing. The patient was given holistic treatment of yoga and Ayurveda, involving patra pinda sweda (herbal compress) and picchu (herbal soaked gauze pieces). The yoga therapy involved asanas practise to increase strength, breathing and meditation for overall wellbeing. The patient was not on any other treatment/medication during the entire treatment. After uninterrupted therapy for six months there was an increase in her bone density along with increase in energy level. The patient case study is an attempt to provide yoga and Ayurveda as an alternative/supportive treatment for remission management osteoporosis from breast cancer patients.

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Use of Alternative Therapy in Postmenopausal Breast Cancer Patients Treated With Tamoxifen After Surgery

Breast Diseases A Year Book Quarterly ◽

10.1016/s1043-321x(05)80183-3 ◽

2005 ◽

Vol 16 (3) ◽

pp. 238

Author(s):

N.C. Russell

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Alternative Therapy ◽

Postmenopausal Breast Cancer ◽

Breast Cancer Patients

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Evaluation of Different Phytochemicals Against BRCA2 Receptor

Biointerface Research in Applied Chemistry ◽

10.33263/briac122.16701681 ◽

2021 ◽

Vol 12 (2) ◽

pp. 1670-1681

Keyword(s):

Breast Cancer ◽

Molecular Docking ◽

Alternative Therapy ◽

Cancer Therapeutics ◽

Receptor Protein ◽

Effective Prevention ◽

Docking Analysis ◽

Cancer Tumor ◽

Phytochemical Compounds ◽

Molecular Docking Analysis

Cancer is one of the most common diseases and remains a leading cause of death worldwide. Breast cancer is one of the major causes of mortality in women. It is one of the most frequent cancers among others. Due to its high mortality, it requires effective prevention. Radiotherapy, immunotherapy, and chemotherapy are the most common methods used to treat breast cancer, but these techniques adversely affect healthy cells. Therefore, an alternative therapy is required to overcome this problem. Phytochemicals from different plant sources are an alternative way for curing infectious diseases and now they are being explored for their anti-cancer therapeutics. In the present study, the BRCA2 receptor protein, which is actively involved in breast cancer expression, was chosen for the molecular docking analysis. This study focuses on evaluating phytochemical compounds from 5 different plants against BRCA2 breast cancer tumor receptors. Prior to computational analysis, a theoretical ADME study was used to rule out a few compounds. Virtual screening of these compounds identified five-hit molecules, which could be further explored in the drug discovery pipeline. Molecular docking analysis revealed that isocolumbin possesses maximum negative binding energy against BRCA2 receptors. These hits were found to be well in range in the bioavailability radar test as well.

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Recent Advances of Novel Therapeutic Agents from Botanicals for Prevention and Therapy of Breast Cancer: An Updated Review

Current Cancer Therapy Reviews ◽

10.2174/1573394715666181129101502 ◽

2020 ◽

Vol 16 (1) ◽

pp. 5-18

Author(s):

Namrata Singh ◽

Poonam Kushwaha ◽

Amresh Gupta ◽

Om Prakash

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Anticancer Agents ◽

Alternative Therapy ◽

Complementary And Alternative Therapy ◽

Lead Compounds ◽

Biomedical Innovation ◽

Bioactive Agents ◽

Day By Day ◽

Preventive Role

Breast cancer is among the foremost common malignancies and the second leading cause for cancer-related deaths in females. Varied treatment approaches are projected to cause a subject matter reduction in the fatality rate. Carcinoma treatment is highly challenging due to therapeutic resistance and reoccurrence. Several studies have revealed that bioactive compounds isolated from natural products such as plants, vegetables, and marine origins have a therapeutic and preventive role in breast carcinoma. Utilization of these bioactive agents in amelioration of cancer as complementary and alternative therapy increases day by day due to growing scientific shreds of evidence of the biomedical innovation and clinical trials. Due to the safe nature of these photochemical investigators are focusing on the investigation of lead compounds from traditional herbal medicine to discover new lead anticancer agents in the single pure compound. This review highlights the mechanism of action and future prospects of novel medicinal agents from botanical sources that have chemoprevention activity against breast carcinoma together with other types of body cancer. The major bioactive, which are used as a remedy for the prevention and treatment of breast cancer, is summarized and explored here.

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Isoflavones

Molecules ◽

10.3390/molecules24061076 ◽

2019 ◽

Vol 24 (6) ◽

pp. 1076 ◽

Cited By ~ 74

Author(s):

Ludmila Křížová ◽

Kateřina Dadáková ◽

Jitka Kašparovská ◽

Tomáš Kašparovský

Keyword(s):

Breast Cancer ◽

Alternative Therapy ◽

The Other ◽

State Of Health ◽

Naturally Occurring ◽

Wide Range ◽

Cancer Types ◽

Potential Risks ◽

Classification Structure ◽

Plant Compounds

Phytoestrogens are naturally occurring nonsteroidal phenolic plant compounds that, due to their molecular structure and size, resemble vertebrate steroids estrogens. This review is focused on plant flavonoids isoflavones, which are ranked among the most estrogenic compounds. The main dietary sources of isoflavones for humans are soybean and soybean products, which contain mainly daidzein and genistein. When they are consumed, they exert estrogenic and/or antiestrogenic effects. Isoflavones are considered chemoprotective and can be used as an alternative therapy for a wide range of hormonal disorders, including several cancer types, namely breast cancer and prostate cancer, cardiovascular diseases, osteoporosis, or menopausal symptoms. On the other hand, isoflavones may also be considered endocrine disruptors with possible negative influences on the state of health in a certain part of the population or on the environment. This review deals with isoflavone classification, structure, and occurrence, with their metabolism, biological, and health effects in humans and animals, and with their utilization and potential risks.

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Laughter and Stress Relief in Cancer Patients: A Pilot Study

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/864739 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

S. H. Kim ◽

Y. H. Kim ◽

H. J. Kim

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Rating Scale ◽

Numerical Rating Scale ◽

Controlled Trial ◽

Alternative Therapy ◽

Control Group ◽

Breast Cancer Patients ◽

Numerical Rating ◽

Anxiety Depression

The purpose of this study was to examine the effect of a therapeutic laughter program and the number of program sessions on anxiety, depression, and stress in breast cancer patients. A randomized controlled trial was conducted involving 31 patients who received four sessions of therapeutic laughter program comprised and 29 who were assigned to the no-program control group. Scores for anxiety, depression, and stress were measured using an 11-point numerical rating scale. While no change was detected in the control group, the program group reported reductions of 1.94, 1.84, and 2.06 points for anxiety, depression, and stress, respectively (p<0.01,p<0.01, andp<0.01). Scores decreased significantly after the first therapeutic laughter session (p<0.05,p<0.01, andp<0.01). As the therapeutic laughter program was effective after only a single session in reducing anxiety, depression, and stress in breast cancer patients, it could be recommended as a first-line complementary/alternative therapy.

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