Advancements and New Technologies in Drug Delivery System

The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. The popularity and usefulness of the formulation resulted in development of several FDT technologies. These techniques render the disintegration of tablet rapidly and dissolve in mouth in five seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Formulation of a convenient dosage form for administration, by considering swallowing difficulty and poor patient compliance, leads to development of orally disintegrating tablets. Conventional preparation methods are spray drying, freeze drying, direct compression, Molding, and sublimation while new technologies have been developed for the production of orodispersible tablets. Keywords: Fast Dissolving Tablet, drug delivery system, fast disintegrating, fast melting.

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Development of a novel drug delivery system to deliver drugs directly to the colonic mucosa, resulting in improved efficacy and reduced systemic exposure for the treatment of ulcerative colitis

Crohn's & Colitis 360 ◽

10.1093/crocol/otab045 ◽

2021 ◽

Author(s):

Merodean Huntsman ◽

Shaoying N Lee ◽

Jack Stylli ◽

Cheryl Stork ◽

Jeff Shimizu ◽

...

Keyword(s):

Drug Delivery ◽

Gastrointestinal Tract ◽

Drug Delivery System ◽

Delivery System ◽

Drug Exposure ◽

New Technologies ◽

Systemic Exposure ◽

Physiological Variables ◽

Novel Drug Delivery System ◽

Novel Drug

Abstract Despite recent drug approvals for the treatment of inflammatory bowel diseases (IBD), there remains a high unmet need for new technologies that can increase drug efficacy by improving site-specific drug delivery while reducing systemic exposure. These technologies must address challenges with formulation; in particular, drugs that are liquid, peptides or proteins are difficult to formulate using existing delayed and extended oral release technologies. They also have the potential to improve efficacy and reduce systemic exposure for certain drugs by delivering higher doses directly to the site of inflammation. A novel drug delivery system (DDS2) is being developed for delivery at a pre-specified part of the gastrointestinal tract. This autonomous mechanical capsule uses an algorithm based on reflected light to deliver soluble formulations of drugs to the predefined location. This system has significant advantages over other traditional delayed release oral formulations because it functions independently of human physiological variables such as pH and transit time and can deliver liquid formulations, peptides, and proteins. Such a system can ensure a predictable high luminal drug exposure and limited degradation or systemic absorption in the upper gastrointestinal tract and would therefore be ideal for treatment of disorders such as IBD and colon cancer.

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Osmotically Controlled Drug Delivery System with Associated Drugs

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/j38w25 ◽

2010 ◽

Vol 13 (4) ◽

pp. 571 ◽

Cited By ~ 31

Author(s):

Brahma Prakash Gupta ◽

Navneet Thakur ◽

Nishi P Jain ◽

Jitendra Banweer ◽

Surendra Jain

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

New Technologies ◽

Plasma Concentrations ◽

Oral Route ◽

Delivery Systems ◽

Transdermal Administration ◽

Physiological Factors

Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Development of an extended release dosage form also requires reasonable absorption throughout the gastro-intestinal tract (GIT). Among the available techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most appropriate one. Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT. This review brings out new technologies, fabrication and recent clinical research in osmotic drug delivery.

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Advances and new technologies applied in controlled drug delivery system

Research on Chemical Intermediates ◽

10.1007/s11164-013-1338-2 ◽

2013 ◽

Vol 41 (4) ◽

pp. 2165-2200 ◽

Cited By ~ 17

Author(s):

Fatma Bassyouni ◽

Noha ElHalwany ◽

Mohamed Abdel Rehim ◽

Munir Neyfeh

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

New Technologies ◽

Controlled Drug Delivery ◽

Controlled Drug Delivery System

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A review on recent innovation in osmotically controlled drug delivery system

Indian Journal of Pharmaceutical and Biological Research ◽

10.30750/ijpbr.2.2.19 ◽

2014 ◽

Vol 2 (02) ◽

pp. 117-129

Author(s):

Neetu R. Gupta ◽

Aditee Mishal ◽

Yogesh Bhosle ◽

Supriya Shetty

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

Water Solubility ◽

New Technologies ◽

Oral Route ◽

Future Perspective ◽

Transdermal Administration ◽

Cr System

In recent years, oral controlled release (CR) system is most acceptable dosage form by the patients. Drugs having short biological half-life and poor water solubility are the suitable candidate for development of CR system. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Development of an extended release dosage form also requires reasonable absorption throughout the gastro-intestinal tract (GIT). Among the available techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most appropriate one. The release of drug(s) from osmotic systems follows zero order. It is mainly governed by various formulation factors such as solubility and osmotic pressure of the core component(s), size of the delivery orifice, and nature of the rate-controlling membrane. The present review highlights an overview of OCDDS. And new technologies, fabrication and recent clinical research in osmotic drug delivery. Further, the challenges of these technologies and its future perspective are also discussed at length.

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