Multi-target Approach for Oxidative Stress Modulation by Aspirin, Salicylates and Other NSAIDs: Clinical Implications in Atherosclerosis

2019 ◽  
pp. 565-578
Author(s):  
Eugenia Yiannakopoulou
Keyword(s):  
Oxidative Stress ◽  
Clinical Implications

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

2018 ◽  
Vol 32 (1) ◽  
pp. 58-71 ◽  
Author(s):  
Vassilios Liakopoulos ◽  
Stefanos Roumeliotis ◽  
Sotirios Zarogiannis ◽  
Theodoros Eleftheriadis ◽  
Peter R. Mertens
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Interventions ◽  
Clinical Implications

Oxidative stress and endothelial dysfunction

2007 ◽  
Vol 27 (01) ◽  
pp. 5-12 ◽  
Author(s):  
G. Muller ◽  
C. Goettsch ◽  
H. Morawietz
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Vessel Wall ◽  
Clinical Implications ◽  
Oxygen Species ◽  
Vascular Oxidative Stress ◽  
Arteries And Veins ◽  
Different Sources

SummaryThis review focuses on the role of vascular oxidative stress in the development and progression of endothelial dysfunction. We discuss different sources of oxidative stress in the vessel wall, oxidative stress and coagulation, the role of oxidative stress and vascular function in arteries and veins, the flow-dependent regulation of reactive oxygen species, the putative impact of oxidative stress on atherosclerosis, the interaction of angiotensin II, oxidative stress and endothelial dysfunction, and clinical implications.

Clinical implications of oxidative stress and antioxidant therapy

2005 ◽  
Vol 7 (4) ◽  
pp. 308-316 ◽  
Author(s):  
Gerald W. Dryden ◽  
Ion Deaciuc ◽  
Gavin Arteel ◽  
Craig J. McClain
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Therapy ◽  
Clinical Implications

scholarly journals IMMUNE AGING AND SERIOUS CLINICAL IMPLICATIONS IN THE ELDERLY IN COVID-19

2021 ◽  
Vol 1 (5) ◽  
pp. e1553
Author(s):  
Eduardo Lopes Barbosa ◽  
Estéphany Miranda Dias ◽  
Letícia Lorem Vilhena de Castro ◽  
Maysa de Vasconcelos Brito
Keyword(s):  
Oxidative Stress ◽  
Intensive Care ◽  
Current Knowledge ◽  
The Elderly ◽  
Clinical Implications ◽  
Low Grade ◽  
Life Threatening ◽  
The Individual ◽  
T Cell Senescence ◽  
And Oxidative Stress

COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in most healthy precedents, but can cause life-threatening illnesses or persistent debilitating symptoms in some cases. The severity of COVID-19 is related to age, with an obligation over 65 years of age, greater risk of needing intensive care. This is a descriptive, exploratory, integrative literature review, with the aim of explaining the current knowledge about the interference of the immunosenescence process in more severe conditions caused by covid-19 in the elderly. Aging is a systemic involution, including the immune system, affecting the individual with several comorbidities, including cardiac, pulmonary and neurological comorbidities that aggravate the situation of vulnerability. Aging is triggered by several mechanisms, among the most relevant are telomere reduction and oxidative stress, which in turn lead to other scenarios such as T-cell senescence, mitochondrial dysfunction and low-grade chronic inflammation, which are added to the mechanism of action of the virus that causes COVID-19, as its key-lock factor involving ACE-2, which has a change in expression during aging, portraying the interferences of this scenario, if not in contact with the major covid-19, which contributes to seriousness in the elderly .

scholarly journals Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

2020 ◽  
Vol 21 (21) ◽  
pp. 7870 ◽  
Author(s):  
Francisco Miguel Gutierrez-Mariscal ◽  
Antonio Pablo Arenas-de Larriva ◽  
Laura Limia-Perez ◽  
Juan Luis Romero-Cabrera ◽  
Elena Maria Yubero-Serrano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Chronic Diseases ◽  
Coenzyme Q10 ◽  
Chronic Obstructive ◽  
Clinical Implications ◽  
Main Function ◽  
Alcoholic Fatty Liver ◽  
Beneficial Effects ◽  
Coq10 Supplementation

Apart from its main function in the mitochondria as a key element in electron transport, Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant action in the generation of signals and the control of membrane structure and phospholipid and cellular redox status. Among these, the most relevant and most frequently studied function is the potent antioxidant capability of its coexistent redox forms. Different clinical trials have investigated the effect of CoQ10 supplementation and its ability to reduce oxidative stress. In this review, we focused on recent advances in CoQ10 supplementation, its role as an antioxidant, and the clinical implications that this entails in the treatment of chronic diseases, in particular cardiovascular diseases, kidney disease, chronic obstructive pulmonary disease, non-alcoholic fatty liver disease, and neurodegenerative diseases. As an antioxidant, CoQ10 has proved to be of potential use as a treatment in diseases in which oxidative stress is a hallmark, and beneficial effects of CoQ10 have been reported in the treatment of chronic diseases. However, it is crucial to reach a consensus on the optimal dose and the use of different formulations, which vary from ubiquinol or ubiquinone Ubisol-Q10 or Qter®, to new analogues such as MitoQ, before we can draw a clear conclusion about its clinical use. In addition, a major effort must be made to demonstrate its beneficial effects in clinical trials, with a view to making the implementation of CoQ10 possible in clinical practice.

Oxidative Stress and Mitochondrial Impairment After Treatment with Anti-HIV Drugs: Clinical Implications

2011 ◽  
Vol 17 (36) ◽  
pp. 4076-4086 ◽  
Author(s):  
Ana Blas-Garcia ◽  
Nadezda Apostolova ◽  
Juan V. Esplugues
Keyword(s):  
Oxidative Stress ◽  
Clinical Implications ◽  
Mitochondrial Impairment ◽  
Hiv Drugs ◽  
Anti Hiv
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