Biomarkers of Oxidative Stress in Cancer, and Their Clinical Implications

2021 ◽  
pp. 1-20
Author(s):  
Palanivel Gajalakshmi ◽  
Thanemozhi G. Natarajan
Keyword(s):  
Oxidative Stress ◽  
Clinical Implications ◽  
Biomarkers Of Oxidative Stress

scholarly journals Isoprostanes in Veterinary Medicine: Beyond a Biomarker

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 145
Author(s):  
Ashley K. Putman ◽  
G. Andres Contreras ◽  
Lorraine M. Sordillo
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Veterinary Medicine ◽  
Biological Fluids ◽  
Biological Action ◽  
Clinical Applications ◽  
Animal Medicine ◽  
Inflammatory Processes ◽  
Oxidized Products ◽  
Biomarkers Of Oxidative Stress

Oxidative stress has been associated with many pathologies, in both human and animal medicine. Damage to tissue components such as lipids is a defining feature of oxidative stress and can lead to the generation of many oxidized products, including isoprostanes (IsoP). First recognized in the early 1990s, IsoP are formed in numerous biological fluids and tissues, chemically stable, and easily measured by noninvasive means. Additionally, IsoP are highly specific indicators of lipid peroxidation and thereby are regarded as excellent biomarkers of oxidative stress. Although there have been many advancements in the detection and use of IsoP as a biomarker, there is still a paucity of knowledge regarding the biological activity of these molecules and their potential roles in pathology of oxidative stress. Furthermore, the use of IsoP has been limited in veterinary species thus far and represents an avenue of opportunity for clinical applications in veterinary practice. Examples of clinical applications of IsoP in veterinary medicine include use as a novel biomarker to guide treatment recommendations or as a target to mitigate inflammatory processes. This review will discuss the history, biosynthesis, measurement, use as a biomarker, and biological action of IsoP, particularly in the context of veterinary medicine.

scholarly journals Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 682 ◽  
Author(s):  
Julia Lorenzon dos Santos ◽  
Alexandre Schaan de Quadros ◽  
Camila Weschenfelder ◽  
Silvia Bueno Garofallo ◽  
Aline Marcadenti
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Cardiovascular Prevention ◽  
Food Sources ◽  
Dietary Antioxidants ◽  
Oxidative Stress Biomarkers ◽  
Atherosclerosis Progression ◽  
Coronary Syndrome ◽  
Biomarkers Of Oxidative Stress

Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antioxidants, such as different kinds of nuts, may improve biomarkers related to oxidative stress, contributing to a possible reduction in atherosclerosis progression. This article has briefly highlighted the interaction between oxidative stress, atherosclerosis, and cardiovascular disease, in addition to the effect of the consumption of different nuts and related dietary antioxidants—like polyphenols and vitamin E—on biomarkers of oxidative stress in primary and secondary cardiovascular prevention. Studies in vitro suggest that nuts may exert antioxidant effects by DNA repair mechanisms, lipid peroxidation prevention, modulation of the signaling pathways, and inhibition of the MAPK pathways through the suppression of NF-κB and activation of the Nrf2 pathways. Studies conducted in animal models showed the ability of dietary nuts in improving biomarkers of oxidative stress, such as oxLDL and GPx. However, clinical trials in humans have not been conclusive, especially with regards to the secondary prevention of cardiovascular disease.

scholarly journals Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress

2015 ◽  
Vol 81 ◽  
pp. 100-106 ◽  
Author(s):  
Maria B. Kadiiska ◽  
Shyamal Peddada ◽  
Ronald A. Herbert ◽  
Samar Basu ◽  
Kenneth Hensley ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Study ◽  
Biomarkers Of Oxidative Stress

Biomarkers of oxidative stress in schizophrenic and control subjects

2007 ◽  
Vol 76 (2) ◽  
pp. 73-85 ◽  
Author(s):  
J. Young ◽  
S.B. McKinney ◽  
B.M. Ross ◽  
K.W.J. Wahle ◽  
S.P. Boyle
Keyword(s):  
Oxidative Stress ◽  
Control Subjects ◽  
And Control ◽  
Biomarkers Of Oxidative Stress

scholarly journals Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in a Mexican-American Cohort: Variability in Early and Late Pregnancy

Toxics ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 7 ◽  
Author(s):  
Nina Holland ◽  
Karen Huen ◽  
Vy Tran ◽  
Kelly Street ◽  
Brian Nguyen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mexican American ◽  
Late Pregnancy ◽  
Phthalate Metabolites ◽  
Biomarkers Of Oxidative Stress

The effects of methylmercury exposure on behavior and biomarkers of oxidative stress in adult mice

2015 ◽  
Vol 50 ◽  
pp. 170-178 ◽  
Author(s):  
Meg Kirkpatrick ◽  
Janina Benoit ◽  
Wyll Everett ◽  
Jennifer Gibson ◽  
Michael Rist ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Mice ◽  
Methylmercury Exposure ◽  
Biomarkers Of Oxidative Stress
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